a cartoon coyote is riding a skateboard with a magnet attached to it ALT: a cartoon coyote is riding a skateboard with a magnet attached to it

That's why you always follow your heart

PXD058490 🚨

Quantitative chemical cross-linking of live cells, organelles, or tissues together with mass spectrometry provides a new insight on protein conformational plasticity within organisms, cells, and tissues.

🚨 New dataset alert! 🚨

US HUPO - Distinguished Contribution Award

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...

Glad to see our antibody design paper finally out in
@nature.com
(and congrats to lead authors and everyone involved )!
At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs.
Paper:
www.nature.com/articles/s41...

Tears are the best solvent to get pump oil off the optics, hope that helps

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...

‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...

#Academicsky
#Chemsky
#teammassspec

Alan Marshall: A scientist and a Gentleman - MagLab Meet one of the greatest innovators in the history of mass spectrometry, hard at work.

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...

The tutorials/demos that are packed with SIMION are a pretty good starting point. They have some examples of the lua code for RF and other time dependent fields. Pretty sure there's a simple quad demo that would be a good starting point for a trap

Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provide New Insight into Protein Conformational Plasticity within Organelles, Cells, and Tissues pubs.acs.org/doi/10....

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#proteomics #prot-paper

I met Michelle Heck at the plant pathology dept chili cook off when I was an undergrad and she was looking for a new student to learn to run her TSQ Vantage. Then I met her collaborator Jim Bruce when he gave a talk on campus a few months later and he offered me a summer job as a tech at UW

We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work

Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...

Job alert 🧪 ‼️ Hi #teammassspec: In our #RTG2467 @unihalle.bsky.social we have a job opening for a PhD student in my group! 🎉 If you want to do cool stuff in cross-linking mass spectrometry of the tumor suppressor p53, please take a look:
personal.verwaltung.uni-halle.de/jobs/wissmi/
Please RT!

I am a mass spectrometrist only because I was fortunate enough to meet Michelle at a chili cook off in 2014

Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.

You can install on anything, the software docs have minimum hardware specs but they're pretty light . There is a correct order to install them in - usually foundation, xcal, tune.

Compute goes brrrrr

Last bit of my PhD work, a four-armed cross-linker (Bisby) prepared by SPPS and a real-time ms3 targeting method written in ITCL based on Chad's original ReACT implementation running on our Velos-FTICR with mito samples from long-time collaborator Arianne.

Multidimensional Cross-Linking and Real-Time Informatics for Multiprotein Interaction Studies pubs.acs.org/doi/10....

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#proteomics #prot-paper

There is a common problem specifically on QE+ interfaced with Waters LCs that causes contact closures from the MS to get fired early that leads to weird things like runs getting closed out early. Can be fixed by configuring the LC to supply cc to the MS instead of vice versa.

The shiny side is only coated if you buy a non-stick foil? Shouldn't matter for normal foil, the shiny side is a manufacturing artifact because only one face touches the roller.