COVID’s origins: what we do and don’t know Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

COVID’s origins: what we do and don’t know www.nature.com/articles/d41...

(A much younger) Me presenting discovery of CTCF and identification of CTCF Like BORIS at the Nobel Symposium in 2004, while talking of their tentative functions in germline vs. cancer, and of secrets beyond... What a journey in 22 years after that! #Epigenetics #CTCF #BORIS #chromosome

Distal enhancers regulate mammalian early embryonic lineage differentiation through long-range interactions Abstract. Histone modifications are key regulators of cell lineage differentiation; however, the roles of histone H3 lysine 27 acetylation (H3K27ac) and hi

Distal enhancers regulate mammalian early embryonic lineage differentiation through long-range interactions url: academic.oup.com/nar/article/...

CTCF-RNA interactions orchestrate cell-specific chromatin loop organization.

Lucero K, Han S, Huang PY, Qiu X, Mazzoni EO, Reinberg D.
bioRxiv [Preprint].

Update in pubmed.ncbi.nlm.nih.gov/41296854/

Sci Adv. 2025 Nov 28; DOI: 10.1126/sciadv.ady5507

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation CTCF binding sites serve as anchors for the 3D chromatin architecture in vertebrates. The functionality of these anchors is influenced by the residence time of CTCF on chromatin, which is determined b...

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation

M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva

revised May 23, 2025
biorxiv.org/content/10.1...

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation

M. Tajmul, D. N. Bhatt, L. Ruje, E. Price, Y. Ji, D. Loukinov, V. B. Teif, V. V. Lobanenkov, E. M. Pugacheva

revised May 23, 2025
biorxiv.org/content/10.1...

www.pnas.org/doi/full/10....

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11. www.pnas.org/doi/full/10....

CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease

Review - Trends Genet. 2001 Sep;17(9):520-7. www.sciencedirect.com/science/arti...

Comparative analyses of CTCF and BORIS occupancies uncover two distinct classes of CTCF binding genomic regions

genomebiology.biomedcentral.com/articles/10....

🥸 Here you can find many verifiable facts and personal commentaries related to the discovery of paralogous CTCF and CTCF Like BORIS transcriptional factors which share near identical eleven multivalent DNA-binding zinc fingers...

...and which used to be @ x.com/boris_ctcf