Altered bone structure in Niemann-Pick Type C1 mice, especially in females Niemann-Pick type C disease (NPC) is a rare lysosomal storage disorder belonging to the group of sphingolipidoses and is caused by a genetic defect af…

New paper in Bone: altered bone structure in Niemann-Pick Type C1 mice, especially in females. Glad to be part of this work as co-author
www.sciencedirect.com/science/arti... doi.org/10.1016/j.bo...

First poster as senior author 👋

AI-based quantification of gut wall thickness in Manduca sexta using clinical CT + U-Net segmentation.

A step toward a high-throughput in vivo model bridging in vitro systems and mouse models in gut inflammation.

Great collaboration with Jan Scherberich
#EMIM #3Rs

My Master’s student Stefan Schmidt developed a reactor to keep Manduca sexta germ-free—enabling microbiome “humanization” and improving translational models for Crohn’s & colitis.

Proud of the team—and especially Stefan! 🚀
#Microbiome #TranslationalResearch

ChatGPT estimates that probably at least hundreds of millions of mice worldwide are killed each year to protect crops and plausibly into the low billions. I bet some die painfully. If we don’t want to torture mice, much has to change!

Congratulations!

1/10
I am truly honored to receive the Hilde Mangold Award from @gfeev.bsky.social!

Mangold’s classic transplantation experiments transformed developmental biology and our understanding of self-organization. I am grateful to be associated with this legacy!

Great to welcome visitors from federal politics today at Fraunhofer IME in Giessen.

I had the opportunity to present our research on insects as alternative model organisms to help reduce the use of mice in biomedical research.

Highlight: exploring the anatomy of Manduca sexta together in VR 🐛🥽

The wonderful historic city of Marburg

🚨 University Marburg (Germany) is recruiting a W2 Professor of Mol. Pharmacology in the Faculty of Medicine.

Focus areas: Epithelial adaptation in #inflammation, #regeneration, and/or #cancer

stellenangebote.uni-marburg.de/jobposting/0...

#AcademicJobs #Pharmacology #FacultyPosition #cellbio

Job opening: Professorship for Molecular Pharmacology at Marburg University, Germany.

We seek a scientifically outstanding researcher in the field of epithelial biology in inflammation, regeneration, and/or cancer.

stellenangebote.uni-marburg.de/jobposting/0...

🚨 PhD Position Available 🚨
I’m recruiting a PhD student to join my lab at the Multiscale Imaging Centre (MIC), Münster, Germany.

www.bischofflab.com/jobs

Fully funded ✅
#Cellbio #Morphogenesis #Microscopy
#Drosophila #PhD
(Details Below)

Original Posting:
stellen.uni-muenster.de/jobposting/d...

3 pictures marked A, B, and C. The first two are of CT machines with multiple shoes poking out. The last is resulting CT scan results. The caption explains: Fig. 1 --QUAC technique. A. Four pediatric patients position in CT gantry aperture. B. Two adult patients positioned for simultaneous examination and (C) resulting image (bottom, liver cysts; top, ruptured spleen [unrelated to patient positioning within gantry])

I finally had to reverse image search this for my own curiosity.

An April Fools' joke from 1984. The full picture used in the article was even funnier.

Link: (to download the PDF to the article) www.ajronline.org/doi/pdf/10.2...

This is a CT

Great opportunity!

🚨 The deadline has been extended until January 31st!🚨

Eyes are wide open now
#irishsetter

So cute 🥰

Our Irish setter puppies….
The eyes are nowopening ☺️

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids - Scientific Reports Scientific Reports - Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids

New paper out 🔥!

Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.

Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...

www.deine-tierwelt.de/kleinanzeige...

Our beautiful, purebred Irish Setter bitch Fine gave birth to 13 healthy and lively puppies today, December 29, 2025.
All seven females and six males are doing very well, and there is already plenty of activity in the whelping box.

Life is better with a setter

This is good news because it is an environmentally friendly way to protect potatoes without lots of pesticides that kill every insect in the field, and therefore it helps protect wild birds.

Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata) - Scientific Reports Scientific Reports - Targeting the proteasome subunit PSMB5 by RNA interference induces proteasome dysfunction and mortality in the Colorado potato beetle (Leptinotarsa decemlineata)

Nature: "This study confirms... accumulation of cell waste in the form of ubiquitin-labeled degrons that correlate with larval mortality."

Translation: The Colorado Potato Beetle becomes constipated to death.

www.nature.com/articles/s41...

The brand new website of the Bischoff lab

... together with my SciArt Gallery :)

So excited to share this as a new junior PI:

My brand-new lab website! 🎉🪰🌀
www.bischofflab.com

Please pass it on to young, motivated researchers looking for PhD positions 😊

And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!

#CellBio #DevBio #PhDjob #PhDposition #Science

🎄 Great Nikolaus moment in the Windfelder Lab!
Isabel surprised everyone with handmade gift bags — such a cool boost to our already amazing team spirit. 🙌

We’re growing! Interested in joining us for a Master’s project or PhD?
👉 windfelder-lab.com

Happy Nikolaus & a great Advent season!

YouTuber Drops Camera in Ocean and Films an Unknown Deep-Sea Species 'So what species is this one? The answer is we have no idea.'

"A YouTuber dropped his camera to the bottom of the ocean and recorded a deep-sea animal that no one has been able to identify."

petapixel.com/2025/11/25/y....

✨ Science Day 2025 (last week) at JLU Giessen!
Great to see our insect-imaging work featured:
Anouk – behavioral fever + imaging
Anna – ultrasound gut-wall
Jan – CT + deep learning
Proud of this team! 🚀

#ScienceDay #Imaging #Manduca

Mammalian apex predators like tigers with solitary lifestyle are more prone to cancer death. Sharks, non-mammalian apex predators, are thought to have low rate of cancer (they have remarkable genome stability and slow rate of evolution). Why are they so different? 🐅🦈🤔

www.nature.com/articles/s41...

Scientists find hidden antibiotic 100x stronger against deadly superbugs A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It…

British and Australian chemists have discovered a powerful new antibiotic called pre-methylenomycin C lactone, hiding in a well-known soil bacterium. This molecule kills drug-resistant bacteria without triggering resistance. buff.ly/YlXaONo
#ShareGoodNewsToo

Allow the lies equal weight to the truth and we're truly fucked. #DeathOfScience #GlobalWarming

Allow the lies equal weight to the truth and we're truly fucked.

#DeathOfScience
#GlobalWarming

@scientistmel.bsky.social
@drstevenhobbs.bsky.social
@flojohorman.bsky.social
@drivingforbush.bsky.social
@brianbrachiopod.bsky.social
@standupforscience.bsky.social

Somehow I couldn’t reach the #Dipteran #Evolution community with my question… so maybe I need something controversial 😄

𝐓𝐡𝐞 𝐠𝐞𝐧𝐮𝐬 𝐂𝐡𝐲𝐦𝐨𝐦𝐲𝐳𝐚 𝐢𝐬 𝐩𝐚𝐫𝐚𝐩𝐡𝐲𝐥𝐞𝐭𝐢𝐜!

#Phylogeny #TreeOfLife #Drosophila #Diptera

(… 𝘐 𝘤𝘰𝘮𝘱𝘭𝘦𝘵𝘦𝘭𝘺 𝘮𝘢𝘥𝘦 𝘵𝘩𝘢𝘵 𝘶𝘱 𝘫𝘶𝘴𝘵 𝘵𝘰 𝘨𝘦𝘵 𝘺𝘰𝘶𝘳 𝘢𝘵𝘵𝘦𝘯𝘵𝘪𝘰𝘯, 𝘱𝘭𝘦𝘢𝘴𝘦 𝘭𝘰𝘰𝘬 𝘢𝘵 𝘮𝘺 𝘲𝘶𝘦𝘴𝘵𝘪𝘰𝘯 𝘣𝘦𝘭𝘰𝘸)