I illustrated my way through the @bsdb.bsky.social Spring Meeting a couple weeks ago - here's my illustrated summary of the conference! I sketched (almost) all the speakers and glimpses of the science that made it such a great few days.
📢 #Preprint alert! 📢
In our lab's latest work, Afnan explores early patterning in the human forebrain using some really cool techniques.
Make sure to check it out!
A ‘tour de force’! First description of human early telencephalon patterning & signalling centre dynamics, coupling transcriptomics & 4D gene expression imaging.
➡️ Human forebrain is distinct from mouse as soon at anterior neural plate closes. First @crick.ac.uk paper from @houartlab.bsky.social
Excited to share our new #preprint uncovering how early human forebrain is patterned.
Compared to mouse, human dorsoventral and anteroposterior telencephalon patterning is strikingly delayed, which is correlated with SHH and FGF signalling differences.
Read it here: www.biorxiv.org/content/10.6...
At the @bsdb.bsky.social conference, Corinne introduced the Marie Johansson Prize to honour our late, brilliant colleague. The award aims to celebrate outstanding early-career researchers. Huge congrats to @giulia-boezio.bsky.social for the award and a stellar presentation of your postdoc research!
We're so proud of our very own Richard for being awarded this fellowship! Onwards and upwards!
Can’t be happier seeing Richard starting this. His original angle to an old problem ( 😉) has great potential for success.
Fascinating to see how findings in dev. neuro. leads to insights in age-related degenerative disorders!
@houartlab.bsky.social @devneuro.bsky.social @kingsioppn.bsky.social
🚨Meet the latest early career researchers awarded Race Against Dementia Fellowships🚨
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
Axonal pathfinding of zebrafish retinal ganglion cells forms the optic nerve. Credit to Dr. Matthew Bostock @houartlab.bsky.social. #ZebrafishZunday 🧪
What a day! Congrats to @danafd.bsky.social for great achievement. Big thanks to Sylvie Retaux & @jamesasharpe.bsky.social for very useful examination of thesis.
Absolutely loved joint supervision w. Zena! Perfect @crick.ac.uk & @kingsioppn.bsky.social combo
Dana’s day had a stiff competition 😉😉😉
Couldn’t be prouder of the first PhD graduate of the lab, super congrats @danafd.bsky.social 🙌🎓🌟. Such a pleasure to supervise you together with @cohouart.bsky.social @houartlab.bsky.social, the learning journey never ends 😌. Huge thanks to @jamesasharpe.bsky.social and Sylvie Retaux for examining 💥
How does foxg1 impact pineal gland development? What are the implications for FOXG1 syndrome?
Lewis Hill, masters student, investigates this in #zebrafish. His image shows in-situ HCR + immuno in foxg1,Gal4;UAS,GFP zebrafish at 24hpf revealing foxg1 mRNA/protein with pineal markers aanat2 & exorh.
Human cortical neurons growing in a dish, with their signal-receiving structures - dendrites - coloured in green by Richard Taylor.
Richard explores how translation of mRNAs into proteins is regulated in dendrites and whether disruptions in this process in dementia contribute to their degeneration.
The red dots are the RNA-binding protein SFPQ, while the translation initiation complex eIF2 is marked in magenta.
Human cortical neurons growing in a dish, with their signal-receiving structures - dendrites - coloured in green by Richard Taylor.
Richard explores how translation of mRNAs into proteins is regulated in dendrites and whether disruptions in this process in dementia contribute to their degeneration.
This week, post-doc Katie Adamson shares an incredible image of a #zebrafish embryo forebrain at 24hpf with membrane labelled tbr2+ excitatory neurons.
Just 24 hours post fertilisation, neuronal cell types are already being born and will come to form the forebrain of this magnificent beast.
This week, post-doc Katie Adamson shares an incredible image of a #zebrafish embryo forebrain at 24hpf with membrane labelled tbr2+ excitatory neurons.
Just 24 hours post fertilisation, neuronal cell types are already being born and will come to form the forebrain of this magnificent beast.
Movie of the week - joined collab of @houartlab.bsky.social & Long lab @kingsioppn.bsky.social @devneuro.bsky.social
@crick.ac.uk
Joining cell identity to cell behaviour in human embryonic brain.
Fascinating >10 days timelapse imaging by @gessicagoncalves.bsky.social
A technical tour de force!
A 3D view of apical radial glia finding their way in the developing human cortex.
A stunning video shared by @gessicagoncalves.bsky.social who cultures organotypic cortical slices to study cell dynamics during human cortex development.
Do tissue material properties impact morphogen transport? Yes! And morphogens know it. Thanks to @nicolettapetridou.bsky.social who got us involved and to Bernat Corominas-Murtra, and kudos to @cami-autorino.bsky.social @dianakhorom.bsky.social and all the authors! 🧵 below if you are curious 👇
Amazing work by Afnan @stochastalive.bsky.social and our lab satellite colleagues @crick.ac.uk, comparing human vs mouse forebrain signalling centres & progenitor diversity in nascent embryonic telencephalon. Outcome of exploration soon on bioRxiv.
@kingsioppn.bsky.social @devneuro.bsky.social
A look at the developing human embryonic forebrain in 3D!
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
The chick is at HH20 (~E3). Can you guess what gene each colour represents?
Another week, another Houart lab image🔬
This week, it's a 3D image of a multiplex, in-situ of a chick forebrain by @danafd.bsky.social who studies early forebrain development in vertebrates & uses HCR to show the expression patterns of gene products instrumental in pallial/subpallial specification.
This week, Rachel Moore shares a gorgeous image from her #zebrafish neuron culture. In a dish, these neurons can grow long axons (magenta). If you look closely, you might be able to see some RNA splicing proteins (green) localised as small puncta along the axons.
This week, Rachel Moore shares a gorgeous image from her #zebrafish neuron culture. In a dish, these neurons can grow long axons (magenta). If you look closely, you might be able to see some RNA splicing proteins (green) localised as small puncta along the axons.
Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!
We are so proud of Triona, Stephania, Joao & Vicky for finishing the London Moonwalk for Marie Johansson, a dear member of our lab and the CDN, who lost her battle against breast cancer last June. Marie was a talented scientist and an exceptional colleague whom we miss terribly.
Donate link below⬇️
This week's image is by @joseriveraz.bsky.social who's tracing the lineage of progenitors in the human developing cortex.
Here, José shows the building blocks of the developing cortex at 10pcw with SOX2 (apical progenitors), CTIP2 & TBR1(neuronal markers), NESTIN (radial glial fibers), and DAPI.
