Impressive. That opens a new path to ncRNA functional classification.

La tribune du Monde était donc une opération de Pollinis
(Tousse)

« Parce que bien cuisiner commence par bien choisir » … il n’existe aucune preuve de différence intrinsèque gustatives entre variétés conventionnelles ou ogm mais on écrit ça tranquille

What does it take to learn the rules of RNA base pairing? A lot less than you may think - Communications Biology Deep-learning models typically require large parameter spaces and extensive training data. Here the authors demonstrate that learning the fundamental biological rules of RNA base pairing can be achiev...

www.nature.com/articles/s42...

Happy to present the latest Corynephage discovered and characterized by Bachelor students at University Paris-Saclay @univparissaclay.bsky.social

cet article est un exemple chimiquement pur du bingo anti biotechnologies

pathétique

comme attendu cette émission n'aura pas permis une juste information du public sur le sujet des NGT !

un fil de débunk (avec toutes les ressources à la fin)

🧵⬇️

1/35

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data.

The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k...

Figure 1 shows they key result

Presentation of scientific work on De Bruijn Graphs applied to the processing of sequencing data in the context of biology. The picture was taken in the conference room of the University of Venice, where a screen displays a slide that introduces De Bruijn Graphs, with the speaker standing in front of it. Being the screen is a large renaissance painting that spans from the floor to the roof.

I had the occasion of presenting nice results about the detection of biological events in De Bruijn Graph at #DSB2026, in the context of my PhD work on #Vizitig !

Thanks to the organizers and colleagues for this amazing and super-inspiring event (and @camillemrcht.bsky.social for the picture).

Beautiful caveat section !

Pour l'importance des pesticides dans l'incidence des cancers, voyez plutot ceci. Les expositions professionnelles (amiante, benzene) sont dans la barre bleue à droite, et les pesticides n'apparaissent nulle part faute de données suffisantes.
www.nature.com/articles/s41...

👇 😨

PREPRINT ALERT

I heard you craving for more combinatorics, here are some more for y'all !

Pour l'importance des facteurs de risque de cancer, voyez plutôt ceci. La petite zone bleu clair, ce sont toutes les causes professionnelles: amiante, arsenic, etc. Les pesticides n'apparaissent nulle part faute de données suffisantes.
Source: Fink et al. Nature Medicine, 2026

More minimizer papers! 😆

Stay tuned: We are now running Metapuccino on SRA’s 1 million human transcriptomes.

This ms. covers the full methodology and discusses the limits of NLP and LLMs for NGS metadata completion.

Usability was a top priority: Metapuccino runs on regular computers with open-source LLMs, but can also scale up on GPUs for large datasets. All it needs is a list of SRA IDs — no pre-processed tables required.

Fiona Hak developed a clever LLM training strategy using the hardest SRA cases — the fine-tuned model is available on Hugging Face.

Metapuccino fills and standardizes 19 key SRA metadata fields in human transcriptomics, using rule-based NLP and a large language model (LLM).

Even simple tasks, like selecting tumor vs. normal samples for a cancer type, require expert curation across multiple tables, protocols, and abstracts.

NCBI’s SRA is a fantastic resource for studying the human transcriptome. But its metadata is messy — over 70% of fields are empty, and information is often inconsistent.

Metappuccino: Large Language Model-driven Reconstruction of Sequence Read Archive Metadata for Cancer Research Motivation: High-throughput RNA-sequencing has significantly advanced transcriptomic profiling in oncology. Millions of RNA-seq datasets have accumulated in public databases such as the Sequence Read ...

www.biorxiv.org/cgi/content/...

What’s behind Metapuccino? ☕️, by PhD student Fiona Hak, @camillemrcht.bsky.social and Melina Gallopin. A thread 👇

Metappuccino: Large Language Model-driven Reconstruction of Sequence Read Archive Metadata for Cancer Research Motivation: High-throughput RNA-sequencing has significantly advanced transcriptomic profiling in oncology. Millions of RNA-seq datasets have accumulated in public databases such as the Sequence Read ...

My algorithmic friends (@camillemrcht.bsky.social) doing LLM stuff : www.biorxiv.org/content/10.1...! And also, screaming last names in the author list ;P. Given my level of trust in Camille, though, perhaps it's time for me to engage more seriously with these models in research...

PostDoc position in bioinformatics and artificial intelligence. PDF available upon request.

Interested in #lncRNA and #ArtificiaIntelligence?
In the frame of our recently founded French-Korean bilateral project DHARP, we are recruiting a post-doc in bioinformatics and artificial intelligence in our team at
@ips2parissaclay.bsky.social
Application limit: 01/12/2025

PubMed is running on autopilot during shutdown, but key independent committee has been abolished www.bmj.com/content/391/... 🧪

Illustration of Burrows-Wheeler Transform and many auxiliary structures from the input string how$now$brown$cow$#

New tool "bwt-svg" for making illustrations of the BWT and the many auxiliary arrays and other structures related to it. Pyodide-based no-installation-necessary interface here: benlangmead.github.io/bwt-svg/. (H/t to @robert.bio for pointing me to pyodide!) Full repo: github.com/benlangmead/....

The MSc. Bioinformatics students of U. Paris-Saclay are organizing the Junior Conference on Computational Biology (JC2B) 2025: AI and predictive models in bioinformatics
November 13, 2025 - I2BC, CNRS, Gif-sur-Yvette, France
Register for free : bioi2.i2bc.paris-saclay.fr/jc2b/#regist...

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

Congratulations to Rayan Chiki, (Institut Pasteur) head of the “Sequence Bioinformatics” unit, for securing the ERC Proof of Concept 2025 for his project ENZYMINER! 👏

‪@rayan.chiki.bsky.social

#Bioinformatics

How to speed up peer review: make applicants mark one another ‘Distributed peer review’ of grants makes process more than twice as fast — and includes some cheat-prevention measures.

Ca a l'air bien, non?
www.nature.com/articles/d41...