Amazing lab to pursue your PhD

Sharing our new preprint summarizing our study on how oral immunotherapy shifts the immune balance of myeloid cells biorxiv.org/cgi/content/....
@FoodAllergyFund

Graphic abstract of paper showing the identification of HpBoRB, a worm protein which binds RELM-beta

Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...

Well deserved! Congrats 🍾🥂

Just published in @AllergyEaaci
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8

Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...

Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...

Congrats on beautiful work Henry and team!

Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection The murine intestinal nematode Heligmosomoides polygyrus bakeri (Hpb) modulates the host immune response via the Hpb alarmin release inhibitor (HpARI)…

🚨 New McSorley lab paper just out in Cell Reports!

Very happy to see this published - it has been a lot of work, and its turned into a really nice story.

In it, we show that HpARI+HpBARI can be used as vaccines

Tutorial thread below (1/16):

www.sciencedirect.com/science/arti...

Take a look at our latest work from @ikinglab.bsky.social identifying an immune-stromal cell axis that mediates disease tolerance against intestinal infection. It's been a pleasure working with a truly collaborative team to make this project a reality.

authors.elsevier.com/c/1kznjL7PXu...

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…

I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.

www.sciencedirect.com/science/arti...

A protective role for IFN-gamma during helminth infections—gotta love it!
Congrats @ikinglab.bsky.social and @susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it #Medsky #immunosky 🪱
authors.elsevier.com/c/1kznjL7PXu...

a purple octopus with big eyes is crawling on the ground in the ocean . ALT: a purple octopus with big eyes is crawling on the ground in the ocean .

🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis

Immunity

www.cell.com/immunity/ful...

The microbiota regulates intestinal goblet cell response and mucin production during enteric parasitic infection via the TLR2-SPDEF axis
www.mucosalimmunology.org/article/S193...

So cool

We have a new baby! We are going to have some beautiful images soon 🪱🔬🧪

Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis Rationale: Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE a...

Preprint 📢📢
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.

www.biorxiv.org/content/10.1...

Sounds like exactly what I was looking for, thanks!

That is interesting, thanks 🙏🏽

I’ll look into that, thanks!

Awesome, I have a specific lesson on mucosal immunity so I would love the slides!

I like that! Thanks

Poly Matzinger absolutely!

Help a new PI!
Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option? #Immunosky 🧪

Hello, Bluesky! ☀️

We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.

Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

🤯

Interesting!

Open minds and close friends is always important, science is no exception 🧪

Would love if you would add me! Thanks