1/ 🔬🧑‍💻 Tired of going back and forth between GUIs and code for your 3D image analysis needs? Would you like to keep your focus in one place (notebook), without sacrificing interactivity? Here’s a tool that can help!

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

Incredible!!!😍 Enhorabona Pau!!!

Just published in @science.org 🚀

By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.

A new platform for tissue engineering and the design of smart active materials! 🫆

www.science.org/doi/10.1126/...

The Two Cytoskeletal Problem // Asynchronous Defense [28] YouTube video by The Lemma Journal Club

We are trying out author rebuttals, so listen to the second half to hear what the authors have to say!

Video links, because the videos are amazing:
www.patreon.com/posts/two-cy...
www.youtube.com/watch?v=zZ0C...

How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology!

Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

Happy #fluorescencefriday (and start of vacation!) to all those who are celebrating
Lifeact-labeled epidermal stem cells closing a wound after in vivo adult zebrafish skin injury

We tracked a zebrafish tail tip for 30h of light-sheet imaging.
It didn’t exist at t=0.

LiLiTTool: CoTracker3 + object detection → real-time microscope steering.
3D, multi-ROI, open source.

www.biorxiv.org/content/10.6...

#bioimaging #lightsheet
thanks @jytinevez.bsky.social

Han, Y. L., Pegoraro, A. F., Li, H., Li, K., Yuan, Y., Xu, G., Gu, Z., Sun, J., Hao, Y., Gupta, S. K., ..., Fredberg, J. J., & Guo, M. (2020). Cell swelling, softening and invasion in a three-dimensional breast cancer model. Nature physics, 16(1), 101–108. #EpithelialMechanics
buff.ly/eIv9nUX

Thread 17: Initial Embryonic Brain Structures.

For the first time, this thread is NOT taken from my notes on the Neural unit in my biology advisor’s 2024 graduate dev bio class, but is largely drawn from the Bianchi “Developmental Neurobiology” textbook. (1/n)

Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff

New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along...

🔥 Check out our new preprint here 👇
www.biorxiv.org/content/10.6...

Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis Pérez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...

Excited to share our new publication on the mechanics of cranial neural tube closure. A really enjoyable and fruitful collaboration bridging Developmental Biology and biophysical modelling. Take a look here!

www.cell.com/current-biol...

Many thanks to @juliaeckert.bsky.social and @onenimesa.bsky.social for all the behind the scenes work you do for running the page! 🙏

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of can...

finally out @vaibhavmahajan.bsky.social! advanced.onlinelibrary.wiley.com/doi/10.1002/...

Curvature of the Drosophila corneal lens depends on localized chitin secretion How does the corneal lens in the fly eye acquire its light-focusing shape? This study shows that centrally located cells produce large amounts of chitin to form the thick central corneal lens, while p...

I am excited to share my new paper in @plosbiology.org . Here we show the role of chitin, a polysaccharide, in controlling the shape of the fly corneal lens.

journals.plos.org/plosbiology/...

Hello epithelia enthusiasts!

I’m @inesfournon.bsky.social and I study epithelial mechanics in sea anemones 🪼

Did you know epithelial cell extrusion had never been described outside bilaterian animals before? Well… not anymore 👀

Read ⬇️🧵1/9

First paper as first & corresponding author, out in PLOS Computational Biology! 🎉
napariTFM brings traction force & monolayer stress microscopy into napari, accessible via GUI; open-source, validated and no coding required. 😉
Check it out 👇

Santos-Oliván, D., Chan, C. J., Torres-Sánchez, A., & Priya, R. (2026). Break to build: fracture as a unifying morphogenetic strategy. Development, 153(16), dev205136. #EpithelialMechanicsReview doi.org/10.1242/dev....

How do tissues maintain their integrity?
Let's discuss epithelial fractures!
High tissue tension can cause cells to break their contacts, leading to rupture!

Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team.

Special thanks to: Jakob El Kholtei, KJ Jenie, @mcolomerr.bsky.social, and of course our wonderful collaborator Bogdan Bintu and my mentor @schierlab.bsky.social

Check out my contribution to the wonderful threads posted by @epimechfc.bsky.social !!

In this one I talk about #3DTFM!

👇

We had covered the history of traction force microscopy (TFM) earlier:
bsky.app/profile/epim...

But what about applying TFM into more physiologically relevant systems, such as those in 3D?

I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Tissue mechanics and synth morphogenesis folks, bump on this:
Would you or someone in your lab be up for a video of a protocol you use getting recorded? The tips and tricks, the hard-to-explain-without-seeing-it-done?

In the name of standardization and reproducibility in the field: get in touch! 🫀

Beautiful thread😍 about Flipper from @juanmagararc.bsky.social #EpithelialMechanics

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

Epithelial Mechanics Fan Club @epimechfc.bsky.social is top-fin #scicomm, in case you haven't heard of it!

Follow them for more like this thread posted by Knaut Lab member and #zebrafish lateral line guru, @weiyiqian.bsky.social 🐟

PhD job alert! 🚨Interested in epithelial mechanics and bacterial infection? Do you have a computational background? Don’t miss this opportunity!

Details in thread 🧵👇

#AcademicJobs #PhDPosition #Biomechanics
Please RT 🔬💻 @epimechfc.bsky.social @unizar.es @i3a.unizar.es @esbiomech.bsky.social

How can structures at the vertex of 3 cells have effects at the tissue level?

Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...

Lobbying in Albany with @uaw.org and @cpw-uaw4100.bsky.social for the Empire Biomedical Research Institute. Learn more:
@fundnyscience.bsky.social.

How does a uniform zygote reliably break symmetry?
How do initially identical cells diverge in cell-cycle timing and transcriptional state?

In our new paper in Nature Physics, we show that embryo geometry itself is sufficient to pattern early development.

www.nature.com/articles/s41...