My first author paper is published in @narjournal.bsky.social , co-led with Satish Nandipati and Ambar Kachale.
In this work, we build on the implications of the unusual genetic code features of Blastocrithidia nonstop...
#RNAsky #RNA #evolution #molecular
academic.oup.com/nar/article/...
Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair.
academic.oup.com/nar/article/...
Thermus thermophilus forms two distinct type IV pili. Cryo-electron microscopy, mutagenesis, structural predictions and simulations reveal their structures, glycan flexibility, and a hypothetical model of pilus assembly.
www.nature.com/articles/s42...
Analysis and Sampling of Molecular Simulations with Adversarial Autoencoders by @guted.bsky.social doi.org/10.1063/5.03...
There is an unplanned power outage in Prague 6. It appears that the servers of the Czech Science Foundation GACR (including #GRIS) are affected and therefore currently unreachable.
Our recent investigation of the constriction in the bacterial ribosomal tunnel is online. Unbiased all-atom MD simulations of the entire ribosome and PDB analysis show, how flexible the constriction is. The flexibility is modulated by short nascent polypetides.
🧬Submissions are still open for our DNA repair and human disease Collection, a cross-journal Collection, highlighting new research and methodological advances.
www.nature.com/collections/...
⚠️ Submission Deadline: 31 January 2026
💡Since November 2025, @springernature.com has introduced "Articles in Press", an initiative giving authors earlier visibility without compromising the quality or integrity of the final publication. ⌛Faster access to accepted research! For more information:
support.springernature.com/en/support/s...
Czech Science Foundation budget as a function of time.
Some thoughts on the chronic underfunding of the Czech Science Foundation. Much of this problem stems from the recent Ministry of Education’s sloppy implementation of funding for non-teaching staff at grammar schools.
gacr.cz/informace-o-...
CAS institutes with the highest number of grants (PI's affiliations):
- Biology center 12 (21)
- Molecular genetics 10 (7)
- Microbiology 7 (9)
Faculties with the highest number of grants (PI's affiliations):
- MFF CUNI 24 (29)
- Science CUNI 16 (24)
- Science MUNI 14 (14)
- Social MUNI 11 (5)
Some facts about the Standard GACR grants awarded this year (in parentheses last year values):
- grants funded: 336 (410)
- budget: 3.0B CZK (3.4B)
- women PI proportion: 25.6% (21.2%)
- proportion of grants in social and humanities: 25.6% (27.3%)
New publication about peptide transport through confined space with some implications for MD simulations of nascent polypeptides in the ribosomal exit tunnel.
pubs.rsc.org/en/content/a...
The 14% success rate the main Czech funding scheme for fundamental research is simply a disaster.
gacr.cz/en/next-year...
Excited to share a fantastic set of sessions coming up at the MDDB Conference:
Day 1: Large-scale MD simulations
Day 2: MD kinetics and free energy / Industrial applications of MD
Day 3: Innovative applications of MD to biological systems
Explore more and register at ➡️ mddbr.eu/conference/
#MDDB
Happy to take part in the workshop. Lots of inspiring discussions. The take-home message: there are many interesting research problems, but only some are truly important.
Day 1 of the winter semester. Good luck to all of us @vschtpraha.bsky.social.
At EMBL @events.embl.org , they know how to conclude a conference.
#EMBLProtein
Research poster heading on yellow background featuring the poster number of 93.
It's 93.
Come and chat on Thursday.
#EMBLProtein
A group of people walking on a path through meadows, with forests in the background. Hilly environment, gray clouds.
Hiking time with Hlouchova lab during our GACR project retreat in Jachymov. A lot of discussions on protein-RNA interactions under probiotic conditions🦠
🥇 Václav Verner (PORG) won 2nd place in the world
🥈 Matěj Pěnička (Gymnázium Nad Alejí)
🥈 Ondřej Michal (Gymnázium Botičská)
🥉 Adam Horák (Gymnázium Hranice)
🗣️ We are pleased to announce that our 2024 Annual Report is out and for the first time in English! ➡️ czexpats.org/en/about-us/...
Our first publication output within the Czech Science Foundation project (25-15428S) about the prebiotic role of peptides in the emergence of the #ribosome.
A scheme of chemico-biological evolution of protein-RNA interactions. It started about 4.5 billion years ago with prebiotic monomers, went through peptides, oligonucleotides, and simple complexes, reaching proteins and RNA at about 4-3.7 billion years ago.
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.
www.sciencedirect.com/science/arti...
To be fair, the organisers have diluted the poster panels over the days👏🏻 So visit the side hall as well, there are many great posters.
Poster is up and I've tried hard to match my t-shirt with the poster title. We're in the front hall, No. 24. Visit us, there's more air than around the posters in the side hall🫠
#EBSA
My temporary office at #EBSA in Rome.
My flight to Rome delayed by 12 hours. Saying goodbye to day 1 of the #EBSA conference and I'm hoping to make it for day 2!
The same poster but cut in halves vertically, so when rolled down it fits to a luggage.
A scientific poster about ribosome simulations. In a viridis colors scale from yellow through green and blue to dark violet.
Heading to #EBSA in Roma and packing my poster to a luggage. Not a fan of poster tubes 🫣
Full text arxiv.org/abs/2503.21357
For Czech readers: The Prague administration has once again shown its incompetence - this time by failing to manage basic demographic data. As a result, young students are paying the price when trying to get into high schools. www.eduin.cz/clanky/nafou...