A roadmap to competitive preclinical packages - Nature Medicine Should researchers avoid translational research in animals in favor of human or AI models? We argue that this debate should focus not on comparing species but instead on how experimental systems can b...

Should researchers avoid translational research in animals in favor of human or AI models?

www.nature.com/articles/s41...

Monthly median Received to Accepted time (days) at Nature Genetics

Postdoc positions now open! We’re moving to Dept of Neurosurgery, U of Colorado Anschutz Medical Campus and have open positions to study brain tumor heterogeneity! If you’re passionate about beating GBM and have experience in related field, this may be for you:
cu.taleo.net/careersectio...

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Congratulations Jamie

I’m reading George Saunders “A swim in a pond in the rain”, which includes lessons from his writing course (he analyzes short stories from Russian masters like Chekhov and Turgenev). As always, I find everything relevant also to science (how to write or judge an article in this case) For example👇

And here is your accompanying editorial: Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development url: academic.oup.com/neuro-oncolo...

Darwin's regrets:
"If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...

The promise of TIL therapy for glioblastoma Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in refractory melanoma and durable responses in lung cancer. Glioblastoma presents distinct challenges for immunotherapy, includin...

The promise of TIL therapy for glioblastoma

www.cell.com/trends/cance...

authors.elsevier.com/a/1m5yH8Z12y...

@dukeneurosurgery.bsky.social
@neurosurgucsf.bsky.social

Yet another great reason to live in Europe!!

Multilingualism protects against accelerated aging 😀

An analysis of aging in >86,000 participants across 27 European countries

Amoruso et al, Nature Aging 🧪⏳

www.nature.com/articles/s43...

Conrad Hal Waddington was born OTD in 1905.

His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.

On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.

🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio

Chimpanzees rationally revise their beliefs The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...

Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...

Back then, it took almost 40 years for his work to be discovered, and even today science communication remains flawed. We must get better at finding and evaluating science and remember that major discoveries may emerge from non-prestigious institutes and appear in non-glamorous journals.

Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary.
Apply → careers.duke.edu/job-invite/2...

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy @science.org
www.science.org/content/arti...

A HER3-targeting antibody–drug conjugate for leptomeningeal metastasis Nature Medicine - The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal...

We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field!
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...

Rescuing dendritic cell interstitial motility sustains antitumour immunity - Nature Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology

This image of a paediatric brain shows collagen (in green), which is a key part of the ECM, with healthy brain (in pink and purple). Researchers hope that targeting components like this that surround a tumour could open new pathways for immunotherapies to better reach and attack cancers.

A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour.

The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.

www.nature.com/articles/s41...

Will the Senate Save NIH? Rescuing biomedical research is every bit as important as saving Medicaid.

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.

prospect.org/politics/202...

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social

🧪

05.02.2025 MEDIA ADVISORY: Senate HELP Committee to Hold Hearing with Secretary Kennedy on HHS Budget WASHINGTON – On Wednesday, May 14, the Senate Health, Education, Labor, and Pensions (HELP) Committee will hold a hearing with U.S. Department of Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. to discuss President Trump's proposed HHS budget for fiscal year 2026. This is the first time in at least two decades that the HHS Secretary is testifying on a presidential budget before the HELP Committee. Agenda: Hearing on Fiscal Year 2026 Department of Health and Human Services Budget; Date: Wednesday, May 14, 2025 Time: 1:00 PM ET/ 12:00 PM CT Location: 430 Dirksen Senate Office Building Witnesses: Robert F. Kennedy Jr., Secretary, Department of Health and Human Services

1/3
PLEASE READ, LIKE, REPOST this "1/3" post

There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...

JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion

www.biorxiv.org/content/10.1...

Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...

Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma - Nature Medicine A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction...

This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social

@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...