New preprint from our lab: enforcing the dormancy gatekeeper ZFP281 can provide long‑term, even lifelong, protection from HER2‑driven breast cancer metastasis by uncoupling dissemination from outgrowth and locking DCCs into dormancy.www.biorxiv.org/content/10.64898/2026.04...
Very exciting findings from a multi-lab collaboration led by @jaguirreghisolab.bsky.social grateful for the opportunity to contribute a bit of our expertise in transcriptome analysis
Grateful to have the opportunity to publish this review with Xiao Peng in Annual Reviews. We set out the challenges and opportunities to use information in rare disease diagnostics from the 98.8% of the human genome that does not encode genes.
www.annualreviews.org/content/jour...
Were you inspired by our paper on the genetics of GLP-1 drug response? www.nature.com/articles/s41...
Want to make impactful discoveries with the world's best genetic dataset? We're hiring!
StatGen: tinyurl.com/ys4mvhej
Risk Prediction: tinyurl.com/psamt294
Data Products: tinyurl.com/2ff7eavb
Introducing PerturbAI.
Today we announced our emergence from stealth with the release of the world’s largest in vivo CRISPR data engine, interrogating thousands of genetic perturbations across 8 million cells throughout the whole brain.
Read More: perturb.ai/news
Why do women account for nearly 2/3rd of all cases of Alzheimer's disease? A new, thorough review, open-access, on its origins in midlife.
@jci.org
www.jci.org/articles/vie...
New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"
Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?
rdcu.be/e7zx7
CellWhisperer can now run on your laptop. Talk to your cells! And check out our paper: www.nature.com/articles/s41...
Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.
faculty-einstein.icims.com/jobs/17847/a...
Please share this with your network: Postdoctoral position available in my group.
www.linkedin.com/jobs/view/43...
Cool work. Always like rigorous methods with positive and negative controls
News from central Jersey: I'm running to represent New Jersey's 12th Congressional District.
By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come!
samwang.substack.com/p/entering-t...
The link doesn’t seem to work on phone, can’t open the website.
This was never really the case. We have known since the 1960s that some of our non-coding DNA has a crucial role in gene regulation: turning the expression of coding genes on & off. It’s been clear for decades that the regulatory DNA is at least comparable in proportion to the protein-coding DNA. /5
Gonadal and sex chromosomal contributions to sex differences in mammalian brain organization www.biorxiv.org/content/10.6... - really nice work from Armin Raznahan @bogglerapture.bsky.social and colleagues
Very good. I have always been wondering why NC doesn’t do it
We identified a novel XIST transcript(s) that is expressed in male in a very specific cell type, Schwann cells, and it has non-XCI related functions. Would like to talk if anyone works on this cell type or XIST😀.
XIST plays a key role in X-chromosome inactivation (XCI) and thought to be transcribed exclusively from the inactive X in female (XX). In this new study led by Kevin O’Leary, a talented MSTP student, we find both views need to be updated. @genomeresearch.bsky.social doi.org/10.1101/gr.2...
Surprising spring flowers in a cold winter day
Don’t know what to make of this. The temp is below 20F, but this spring flower??
AI created cartoon mouse doing research
In prep for a talk, I asked DALL•E to make an image of “mouse developing heart”. It became more creative than I expected and got me this 😂
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social
“A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬
www.cell.com/cell-stem-ce...
A robot on a chair sits next to a patient against a backdrop of a medical report. Credit: mathisworks / DigitalVision Vectors / Getty Images
🚨To celebrate #WorldMentalHealthDay, our October issue includes a Focus that examines the advances in computational psychiatry and the challenges of developing computational models to address mental health disorders. #mentalhealthresearch #Psychiatry
➡️ nature.com/collections/...
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Excited to have Mark from Yale visit us and speak in our AI seminar series tomorrow, co-sponsored by the new Data Science Institute at @einsteinmededu.bsky.social lots of to learn and catch up
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f
Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience
➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?
Check out what we found!
🧵1/n
Still like UMAP? Why stop at one when you can make lots of them. Then you may learn something new from them and if they represent your data well.
PSA:
if you're not a mouse person you may enjoy knowing that mouse Sca1 (the hematopoiesis marker) is not encoded by Sca1 (spinocerebellar ataxia 1) but rather Ly6a.
I mean, OF COURSE it is. What else could it be?
I'm an hg38 person and below is a self-portrait while I was figuring this out.
“With these considerations, we expect to fund through the 4th percentile.”
There it is, in black and white, the destruction of cancer research in the US.
