Big congrats to Spencer Thompson on defending his thesis today! Beautiful @lumicks.bsky.social C-Trap single-molecule work and a major MD/PhD milestone. Proud PI! BioRxiv coming soon.

Come work with us! Please share with anyone who might be a good fit!

Great lab, two thumbs up,highly recommend.

Our lab at the UC Irvine is currently hiring a postdoctoral researcher. We have a thriving and growing biomedical research campus and are looking for candidates with a strong interest in DNA damage and repair, cancer etiology, and cancer health disparities. Apply at recruit.ap.uci.edu/JPF09440

Learning, leading and lifting others Tigist Tamir’s journey from aspiring astronaut in Ethiopia to cancer researcher at the University of North Carolina highlights the power of mentorship, persistence and curiosity in shaping a scientifi...

As a child, @phosphotig.bsky.social dreamed of being an astronaut, but her curiosity led her to scientific research. Now, she leads her own lab at UNC-Chapel Hill, & studies oxidative stress to find better therapies for triple-negative breast cancer. #WomensHistoryMonth
www.asbmb.org/asbmb-today/...

What luck! Probably frees some time up for a Tar Heel game...or, really, ABD.

The correct attitude: Go Heels! Or whichever team plays dook.

At least its not Jeremy Strark, the famous scientist. That dude in the picture is much better looking.

Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial
impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis.
#AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria

www.nature.com/articles/s41...

The Sfeir Lab at MSKCC is hiring a Research Assistant!
We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested

Corbet's couloir next? Stefan's chute? too soon?

Just in time for my grad school lecture on NER!

Great conference!!

RNAseH2 is super picky...which is not always a good thing?

Yup...basic research PI, greatest job ever. Most of the time.

100% agree. would definitely recommend.

Very cool!

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals www.biorxiv.org/content/10.64898/2025.12...

Adam Luthman says: it depends. Some answers here: rdcu.be/eUVBj

Or does NHEJ repair one strand, leaving the opposite strand for a single strand break repair pathway?

Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?

Great piece of work - congratulations, all!

Very cool! Figs 2 and 3 are especially cool!

So cool. And hey, its a good thing NHEJ doesnt slow down when you get sleepy.

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes - Nature Communications DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

Base excision repair in chromatin: A tug-of-war for DNA damage Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…

🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs!
Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability.
Built on Tyler's foundational work! tinyurl.com/ywkt2bt5

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....

Great scientist. "One of the most influential" - definitely.

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Pol delta's exo at it again!