These antibodies target distinct epitopes somewhat conserved among H5 on HA globular head and are more potent than HA stem antibodies. The study was led by VRC in collaboration with @jbloomlab.bsky.social at Fred Hutch and Reed lab at UPitt. Huge thanks to all who contributed to the work! 2/2

Just out📢 Our new paper published in @natmicrobiol.nature.com describes highly potent cross-neutralizing human monoclonal antibodies against H5Nx influenza viruses. Close collaboration with Sara Andrews lab and Tongqing Zhou lab at the VRC. Link to the article: rdcu.be/eKV9T 1/2

That’s brilliant. Congrats Jason! Richly deserved.

Nice pictures of you two. Not to scale tho.

Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques www.biorxiv.org/content/10.1101/2025.02....

Pre-exposure antibody prophylaxis protects macaques from severe influenza Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasu...

Also last week in @science.org : @kanekiyom.bsky.social, Douglas Reed, Simon Barratt-Boyes, & colleagues show pre-exposure broadly neutralizing #antibody ( #bnAb ) #prophylaxis against a conserved supersite on #influenza #hemagglutinin (HA) stem protects #macaques against #H5N1 infection! #BirdFlu

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1 Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed mill

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies www.biorxiv.org/content/10.1101/2024.11....

Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem Ataca et al. describe a pathway to generate cross-reactive B cells against influenza hemagglutinin by engaging a subdominant immunoglobulin germline-encoded motif through prime-boost vaccination in IG...

📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...

New Antibodies Target “Dark Side” of Influenza Virus Protein Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of the neura...

Here’s a link for NIAID media release covering our paper. go.nih.gov/2Lb9nnn

Hot off the press! Our latest paper on #influenza neuraminidase (NA) antibodies has just been published in Immunity. Lederhofer et al. Isolated and characterized human antibodies to the NA ‘dark side’ that are broadly cross-reactive and protective. www.cell.com/immunity/ful...