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Posts by Ousmane H. Cisse

Hi Jacob, please include me. Thanks

5 months ago 1 0 1 0
Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".

Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".

Our September issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella

#IDSky #ClinMicro #OA

7 months ago 9 11 2 1

Homology-mediated transformation of frog-killing fungus Batrachochytrium dendrobatidis illuminates chytrid development and pathogenesis www.biorxiv.org/content/10.1101/2025.08....

7 months ago 3 2 0 0
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Why are there so few pathogens? Ecology and evolution in pathogen emergence Why are there so few pathogens, and what determines their emergence? This Perspective argues that ecological and evolutionary forces (host availability, geographic exposure and microbial innovation) w...

Interesting perspective - few more to add from fungal pathogens perspective. Also pathogens and hosts often operate on different molecular clocks. journals.plos.org/plosbiology/...

7 months ago 4 2 0 0

In this review, @liangma20854 et al. discuss #Pneumocystis epidemiology, coinfection, cross-infection, and coevolution aspects. #pneumonia
buff.ly/3X0yKSR
#FEMSMicrobiolRev

9 months ago 4 3 0 1
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Extracellular Vesicle-Mediated Delivery of Genetic Material for Transformation and CRISPR/Cas9-based Gene Editing in Pneumocystis murina Pneumocystis species are obligate fungal pathogens that cause severe pneumonia, particularly in immunocompromised individuals. The absence of robust genetic manipulation tools has impeded our mechanis...

www.biorxiv.org/content/10.1... - really cool study from U. Cincinnati

9 months ago 2 0 0 0
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Cosmic Radio Interview with Dr. Joseph Heitman: Professor and Chair of Molecular Genetics and Professor in Medicine at Duke University and CIFAR's Co-Director for the Fungal Kingdom: Threats & Opportu... Join me on Cosmic Radio as we speak with Dr. Joseph Heitman. Dr. Heitman is a professor and Chair of Molecular Biology and Professor in Medicine at Duke University and CIFAR's Co-Director for the "Fun...

share.transistor.fm/s/ee922716 - nice interview with Joe Heitman on Fungi

11 months ago 13 7 0 1
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Retracing the evolution of Pneumocystis species, with a focus on the human pathogen Pneumocystis jirovecii | Microbiology and Molecular Biology Reviews SUMMARYEvery human being is presumed to be infected by the fungus Pneumocystis jirovecii at least once in his or her lifetime. This fungus belongs to a large group of species that appear to exclusivel...

journals.asm.org/doi/abs/10.1...

11 months ago 3 0 0 0
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Single-Cell RNA Sequencing Defines Developmental Progression and Reproductive Transitions of Pneumocystis carinii Pneumocystis species are host-obligate fungal pathogens that cause severe pneumonia in immunocompromised individuals. Despite their clinical importance, their life cycle remains poorly understood, in ...

www.biorxiv.org/content/10.1...

11 months ago 2 2 0 0
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CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis Pneumocystis jirovecii pneumonia (PCP) is a leading cause of fungal pneumonia, but its diagnosis primarily relies on invasive bronchoalveolar lavage (BAL) specimens that are difficult to obtain. Oroph...

pmc.ncbi.nlm.nih.gov/articles/PMC...

1 year ago 0 0 0 0
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Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly - Communications Biology Early-life lung microbiota is dynamic, with major shifts at 3–4 months. Transient microbes dominate, but some persist, influencing lung health. Pneumocystis jirovecii may be a key driver of microbial ...

Interesting hypothesis worth exploring further www.nature.com/articles/s42...

1 year ago 0 0 0 0
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Selective expression of Pneumocystis antigens in different patients during a suspected outbreak of Pneumocystis pneumonia | mBio The fungus Pneumocystis causes severe pneumonia in patients with weakened immune systems. It possesses a genetic system to vary the antigens at the surface of its cells that are presented to the immun...

journals.asm.org/doi/10.1128/...

1 year ago 1 0 0 0
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Fungal infections are ‘taking over the world’. Can they be stopped? As a landmark WHO report warns of a lack of treatments and diagnosis, we investigate a threat that now kills twice as many people as TB

Nice article in The Telegraph today about importance of fungal infections and the need for more research. Lots of quotes from UK researchers!
www.telegraph.co.uk/global-healt...

1 year ago 24 7 0 0
Visual abstract

Visual abstract

Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV – A systematic review and network meta-analysis of randomized controlled trials

Hatzl et al

TLDR: “no clear best choice”

www.clinicalmicrobiologyandinfection.com/article/S119...

1 year ago 23 8 0 0