Extracellular vesicles manage to slip gene edits into Pneumocystis fungi Pneumocystis is an unwieldy genus of fungal pathogens that cause severe pneumonia, particularly in immunocompromised people like those with HIV/AIDs or who have received organ transplants. However,…

Extracellular #vesicles manage to slip #gene edits into #Pneumocystis #fungi ...

| #pathogens | #pneumonia | #HIV | #AIDS | #microbes | By @asm.org via @sciencex.bsky.social

great case from latest NEJM: new #HIV diagnosis with #PJP pneumonia & isolated #cryptococcus pneumonia without meningitis. Lessons: everyone should get hiv test/we do this in our ED. other clues recent zoster. pic: crushed ping pong balls: #pneumocystis DOI: 10.1056/NEJMcpc25135 Pt doing well on ART

1,3 β-D-glucan component of cell wall of #Pneumocystis cysts, often elevated in PLWH
-sensitivity of β-glucan for PJP dx appears to be high, thus PJP is less likely in PLWH with low level<80
-specificity of β-glucan for PJP dx is low since other fungal dz, cellulose membranes for HD can elevate it

#PJP PCR is highly sensitive and specific for detecting #Pneumocystis. While PCR cannot reliably distinguish colonization from active disease, quantitative PCR is favored over qualitative assays, as a higher organism load by qPCR is likely to represent clinically significant disease.

#pneumocystis in pt living w/ HIV: slow development, milder dz, 10-12% mortality. Non-HIV: rapid development, severe, 30-50% mortality. Dx gold standard microscopic of organism in respiratory tract by stain or pcr

#pneumocystis acquired via inhalation of cyst. Primary infection in first 2yrs of life. Rare person-person transmission during outbreaks have been reported in immunocompromised. Environmental factors influence hospitalization. Colonization is common associated w/ obstructive airway dz

#Pneumocystis #Jirovecii Pneumonia #PJP

The 2025 EQUAL Pneumocystis Score—an ECMM tool to measure QUALity in Pneumocystis pneumonia management Pneumocystis pneumonia (PCP) is an opportunistic fungal infection. Several guidelines have been published to support its clinical management. However, the complexity and breadth of these guidelines pose challenges for consistent implementation in ...

New in JAC-AMR: The 2025 EQUAL #Pneumocystis Score provides a concise, evidence-based tool to improve guideline adherence in Pneumocystis pneumonia care for patients with or without HIV. 🔍
pmc.ncbi.nlm.nih.gov/articles/PMC...

#PCP #FungalInfection #InfectiousDiseases #MedicalMycology

Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".

Our September issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella

#IDSky #ClinMicro #OA

New research article

Association between mycophenolic acid treatment and infection with specific strains of #Pneumocystis jirovecii in solid organ #transplant recipients in France and Switzerland

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #MycoSky #OpenAccess #OA

Callum and Alyssa did this episode without me, which I’ll never forgive them for, but I can’t deny this episode is a cracker.

ID:IOTS podcast episode on PCP out now!

Another episode on Cotrim dosing will be released ‘shortly’*

#IDSky #Microsky #fungi #PCP #PJP #Pneumocystis

*I’M GETTING TO IT

In this review, @liangma20854 et al. discuss #Pneumocystis epidemiology, coinfection, cross-infection, and coevolution aspects. #pneumonia
buff.ly/3X0yKSR
#FEMSMicrobiolRev

Discover latest study by Yi Koh et al. on #Pneumocystis #Pneumonia infections in a non-HIV cohort. The research explores the #Inflammatory phenotype in 62 individuals by means of C-reactive protein #CRP levels in a retrospective analysis. Dive into the results: buff.ly/PqS8CW6 #PathogDis

100+ people connected. Soon in @escmid.bsky.social #eLibrary!

Antifungal prophylaxis in hematological malignancy patients and SOT

Next #EFISG_Webinar... 29 April 2025 at 16:00 - 18:00 CET

#Pneumocystis diagnosis and #MALDI-TOF MS update, together with @ishamycology.bsky.social

The Intervention – 1997 Michael P Moore
I painted this just a little over a year after surviving 4 separate life-threatening health crises! #Tuberculosis #Pneumocystis #CMV and a broken #PortaCath line and #Angioplasty! #Unkillable! #Art #Painting #Symbolism #Impressionism #Abstract #ArtSky

Serum #galactomannan is NOT helpful in dx of #Pneumocystis jirovecii pneumonia because its cell wall does NOT contain galactomannan #IDSky #PathSky #MedSky #PJP