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Posts by David Hourigan

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New in Nature Protocols buff.ly/DUCGVAf

A standardised method for reproducible tracking of gut bacteria via the SIHUMI microbial community.

Congrats to APC researchers Natalia Rรญos Colombo, Mariana Perez-Ibarreche, P.Ross & C.Hill, in collab with Pranav Lanka at @tyndallinstitute.bsky.social

4 weeks ago 9 2 2 1
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New APC paper in Molecular Nutrition & Food Research.
First author Felipe Miceli de Farias & colleagues identifed a new circular bacteriocin from Streptococcus. The study is part of the research of Prof. Paul Ross's group at APC.
onlinelibrary.wiley.com/doi/10.1002/...
#Bacteriocins #UCC #Teagasc

2 months ago 2 1 0 0
We previously engineered Saccharomyces cerevisiae through CRISPR-Cas9 integration to produce Ply511, a bacteriophage endolysin active against L. monocytogenes, showing the potential of engineered yeast to produce endolysins for biocontrol. In this study, we extended this approach to the probiotic yeast S. boulardii and directly compared the two yeasts as secretion hosts for Ply511. Using a simulated human gastrointestinal environment, we evaluated their ability to retain endolysin activity and reduce L. monocytogenes levels.

We previously engineered Saccharomyces cerevisiae through CRISPR-Cas9 integration to produce Ply511, a bacteriophage endolysin active against L. monocytogenes, showing the potential of engineered yeast to produce endolysins for biocontrol. In this study, we extended this approach to the probiotic yeast S. boulardii and directly compared the two yeasts as secretion hosts for Ply511. Using a simulated human gastrointestinal environment, we evaluated their ability to retain endolysin activity and reduce L. monocytogenes levels.

New paper from the CEB- @uminho.bsky.social & APC
๐„๐ฏ๐š๐ฅ๐ฎ๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐ญ๐ก๐ž ๐๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒ ๐จ๐Ÿ ๐š๐ง ๐š๐ง๐ญ๐ข-๐‹๐ข๐ฌ๐ญ๐ž๐ซ๐ข๐š ๐ž๐ง๐๐จ๐ฅ๐ฒ๐ฌ๐ข๐ง ๐ฏ๐ข๐š ๐‚๐‘๐ˆ๐’๐๐‘-๐‚๐š๐ฌ๐Ÿ— ๐ž๐ง๐ ๐ข๐ง๐ž๐ž๐ซ๐ž๐ ๐ฉ๐ซ๐จ๐›๐ข๐จ๐ญ๐ข๐œ ๐‘บ๐’‚๐’„๐’„๐’‰๐’‚๐’“๐’๐’Ž๐’š๐’„๐’†๐’” ๐’ƒ๐’๐’–๐’๐’‚๐’“๐’…๐’Š๐’Š
Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social

1 month ago 4 3 1 0
 Diarmuid Oโ€™Brien, CEO of Research Ireland; Dr Paddy Austin, Assistant Director for ERDF, Northern and Western Regional Assembly; Professor Garry Duffy, Director of ARC Hub for HealthTech, University of Galway and RCSI; Professor David Burn, President of University of Galway; Elena Panteva, Directorate General for Regionalโ€ฏ&โ€ฏUrban Policy, European Commission.

Diarmuid Oโ€™Brien, CEO of Research Ireland; Dr Paddy Austin, Assistant Director for ERDF, Northern and Western Regional Assembly; Professor Garry Duffy, Director of ARC Hub for HealthTech, University of Galway and RCSI; Professor David Burn, President of University of Galway; Elena Panteva, Directorate General for Regionalโ€ฏ&โ€ฏUrban Policy, European Commission.

The new ARC Hub for HealthTech was officially launched today at @uniofgalway.bsky.social. The Hub will drive the development of solutions to improve chronic disease management. Read more: www.researchireland.ie/news/arc-hub... #EUInMyRegion @atu-ie.bsky.social @rcsi.bsky.social

1 month ago 4 2 0 0
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Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Very cool paper www.nature.com/articles/s43...

The authors found that FMTs from *older* mice into adult females improved ovarian function and lowered inflammation.

FMTs from younger mice into adult mice led to higher inflammation and *reduced* ovarian function in older mice.

1 month ago 8 2 1 1
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SFA Talks from @Kristinacampbell, Sean Gibbons, and Howard Bauchner offered invaluable wisdom on science communication, career development, and strategies for publishing in high-impact journals! ๐Ÿ™Œ #ISAPP2025

9 months ago 3 3 0 0
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This year marked my first @isappscience.bsky.social annual meeting as part of the @isappsfa.bsky.social executive committee (Communications)
Brilliant science, thoughtful discussion, and great company throughout.
A huge thank you to my fellow committee members, Iโ€™m already excited for next year!
๐Ÿซถ๐Ÿผ

8 months ago 2 1 1 0
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#ISAPP2025 Afternoon sessions underway with talks from Haruki Kitazawa, Guy Vergeres and Maria Marco! ๐ŸŽค
@isappscience.bsky.social

9 months ago 3 1 0 0
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Day 3 of #ISAPP2025 begins with IAC selected talks from Maria Rodriguez-Palmero Seuma(Effects of a probiotic formula on symptoms and quality of life in peri- and postmenopausal women) & Elaine Vaughan(Towards EU health claims for prebiotics: A focus on scientific evidence and regulatory pathways)๐Ÿ™Œ

9 months ago 1 1 0 0
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SFA highlight talks from Valentina Cattero (Prebiotic-like activity of cranberry extract: Modulating gut microbiota composition and enhancing intestinal barrier function in ex vivo and in vivo models) & Kait Al (Acetate and the gut-brain axis: A pilot study on mental health and metabolic outcomes)๐Ÿ‘

9 months ago 3 1 1 0
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A huge congratulations to our ISAPP SFA Poster Winners for 2025! We are delighted to present Benjamin Levine and Caroline Dricot with their awards ๐Ÿ†๐Ÿ‘
#ISAPP2025
@isappscience.bsky.social

9 months ago 2 1 0 0
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Member registration 2025 โ€” ISAPP Students and Fellows Association

โœจSFA Membershipโœจ

To join/renew your membership, fill out our registration form (there's no fee to join).

isapp-sfa.com/member-regis...

SFA Membership allows you to connect with an amazing network of ECRs, keep up to date on SFA blogs & events and the opportunity to attend our annual meetings!๐ŸŒ

1 year ago 3 2 0 0
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This month's ISAPP-SFA blog by Brendan Daisley presents theย R package,ย isolateR, designed to meet the high-throughput demands of modern microbial isolation workflows!ย ๐Ÿ”ฌ

๐Ÿ“– www.isapp-sfa.com/new-blog/202...

๐Ÿ“ฅ Never want to miss a blog post? Register at www.isapp-sfa.com/member-regis...

1 year ago 3 2 0 0
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Mobile genetic elements: the hidden puppet masters underlying infant gut microbiome assembly?

-in Microbiome Research Reports by @kkreuze.bsky.social @frimanscience.bsky.social and Tommi Vatanen

www.oaepublish.com/articles/mrr...

1 year ago 19 9 0 0
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Discovery and synthesis of leaderless bacteriocins from the Actinomycetota | Journal of Bacteriology Bacteriocins are gathering attention as alternatives to current antibiotics given the increasing incidence of antimicrobial resistance. Leaderless bacteriocins are considered a commercially attractive...

Discovery and synthesis of leaderless bacteriocins from the Actinomycetota

journals.asm.org/doi/10.1128/...

1 year ago 0 0 0 0
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