Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...
impressive!
Thinking about this more, the 2 and 3 year bans are real career killers… who’d hire a tenure track candidate, or an (associate) professor that has one of those hanging around their necks?
Phosphoregulated SMCR8-FIP200 interaction connects the ALS/FTD-linked C9orf72 complex to autophagy initiation and mitochondrial quality control www.biorxiv.org/content/10.64898/2026.04...
Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy
Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies
portlandpress.com/biochemj/art...
1/13 🧵
‼️Preprint alert.
Are you interested in synthetic protein binders? Do you need to generate them?
I present to you IARA: a fast, slim ML model that tells you which protein surfaces are good for binder design.
www.biorxiv.org/content/10.6...
PhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance
go.nature.com/422vHhs
We're gearing up to generate iPSCs stably expressing ASAPs, and are compiling a list of potential users who might want these to study cell fate pathways for neurons or cardiomyocytes, or to perform drug screening.
If these would be useful to you, please message me in the chat
Out now in @science.org
Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...
A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...
Take a look at our Research Highlight: Adriana Golding et al.
www.nature.com/articles/s41...
We highlight the work by Ghoochani et al., who generated an atlas of brain lysosomal proteins and identified SLC45A1-associated disease as a lysosomal disorder:
www.cell.com/cell/fulltex...
get well soon!
Cells drastically downregulate mRNA translation to save energy during stress. A study by the Weis lab (IBC) shows that mRNAs transcribed after stress escape repression while pre-existing mRNA don’t, in a timing mechanism that is independent of mRNA sequence. More: biol.ethz.ch/en/news-and-...
Interesting study about the gender gap in publishing. Not sure if 7% longer review time for female scientists is really something, but I do know that indeed we must prove competence more than our male counterparts journals.plos.org/plosbiology/...
"AI swarms are … equipped to exploit this by engineering a synthetic consensus …" Schroeder et al.
In a new #SciencePolicyForum, researchers discuss the risks of malicious “#AI swarms,” which enable a new class of large-scale, coordinated disinformation campaigns that pose significant risks to democracy. https://scim.ag/49FIhrM
how expensive is a Gemüse Kebab nowadays?
After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex...
TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments.
More below 👇
Left panel: Immunofluorescent microscopy showing that Mtch mutant intestine cells (blue nuclei that lack red dye) fail to clear mitochondria marker protein ATP5A (green). Right panel: Transmission electron microscopy image of a mitochondrion engulfed by an autophagosome of a Drosophila intestine enterocyte.
Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg
A study published in Nature Communications reveals that exposure to certain food preservatives, including potassium sorbate and sodium nitrite, correlates with a higher risk of developing type 2 diabetes. 🧪
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists
Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share
Stream bit.ly/microscopist...
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
#spatialgeneexpression
#RNAlocalizatiom
#RNAsky
www.nature.com/articles/s41...
A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
What is RNA velocity in situ? ChatGPT kept getting it wrong...
So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0
#AcademicSky
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉
🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
