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Posts by Pauli Group (posts by Andi Pauli)

Thank you to the Biochemical Society for having established such an Award for the 'Leaders of Tomorrow', and thank you for awarding it to such a deserving candidate like @lorenzoorts.bsky.social! Big congrats Laura!

6 days ago 1 0 0 0

Big congratulations to our former postdoc @lorenzoorts.bsky.social, now leading her own at the @imbmainz.bsky.social, for receiving the Biochemical Society Early Career Research Award! Amazing news and so well deserved - super proud of you, Laura!

6 days ago 9 1 1 0

๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡ If are you excited about helping us recruit and train the next generation of scientists, don't hesitate to apply! The @viennabiocenter.bsky.social is a great place to work. ๐Ÿ™‚

3 weeks ago 9 5 0 0

A big shout-out for @lorenzoorts.bsky.social and @hohmannulrich.bsky.social - super happy for both of you that it worked out!
If I was a student starting my career and interested in mechanistic work at the interphase of biochemistry/structural biology/development, I would immediately apply!

1 month ago 7 1 0 0
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Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. ๐Ÿ‘ @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

1 month ago 181 77 6 8
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We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

1 month ago 107 125 1 4
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Learn more about the collaboration possibilities offered at Vienna BioCenter as Victoria Deneke shares her insights as a Postdoc at the Research Institute of Molecular Pathology.

The VIPยณ PostDoc Program call is open โ€“ apply now! training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

1 month ago 17 8 1 0

What an opportunity! Donโ€™t miss it!!

1 month ago 4 4 0 0
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Thanks a lot Yasin for the shout-out!

1 month ago 1 0 0 0

Congrats Annika on launching the Nichols lab - fantastic news!!

1 month ago 2 0 1 0

Excited for the years to come working with this great crowd @juliusbrennecke.bsky.social @pauligroup.bsky.social @haselbachlab.bsky.social & Andela Saric! ๐Ÿฅณ

1 month ago 55 3 1 0

I could not agree more with @trayon.bsky.social:
We were all supported by amazing scientists, mentors & colleagues that allowed us to achieve our dreams. I want to be such a supportive mentor myself & give back by supporting others - from my own @pauligroup.bsky.social members to other scientists!

1 month ago 3 0 0 0

And could not agree more with Teresa:
We were all supported by amazing scientists, mentors and colleagues that allowed us to achieve our dreams. I want to be such a supportive mentor myself and give back by supporting others - from my own @pauligroup.bsky.social members to other scientists!

1 month ago 3 0 0 0

This was such an inspirational visit to the @cambiochem.bsky.social (thanks to @ericmiska.bsky.social & Ulrika Yuan for inviting & hosting), and then informally catching up with @trayon.bsky.social + lab @babrahaminst.bsky.social and Juliette Fedry @cellbiol-mrclmb.bsky.social! Science is fun!

1 month ago 10 1 1 0

the deadline is coming soon๐Ÿ‘‡ don't miss it, we are looking forward to welcoming all teleost (not just zebrafish ๐Ÿ˜‰) afficionados in Vienna! ๐Ÿ™‚๐ŸŸ๐Ÿ ๐Ÿค“

1 month ago 5 7 1 0
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Welcome Danny to our campus! Looking forward to interacting more and having you around!

1 month ago 11 1 0 0

One more week to finalize your applications for the 2026 MBL zebrafish course at Woods Hole!

Application deadline extended to March 9.

Please repost and forward to anyone interested in learning 'everything zebrafish'!

www.mbl.edu/education/ad...

1 month ago 7 6 0 1
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Just published: chemotactic sperm cells become phototactic ๐Ÿ’ก- by loading photo-activatable second messengers. This allows to "reverse-engineer" chemotactic signaling dynamics and expose cells to signals they would never see in the wild. Honoured to be part of this collaboration with the Kaupp lab.

1 month ago 68 18 2 3

Interested in expanding your zebrafish skills or completely new to zebrafish as model system for your research question? Then this course is for YOU!
Deadline for applying is on March 2nd, so get your applications in.

PS: It's a fantastic course - changed my own career!

www.mbl.edu/education/ad...

1 month ago 4 1 0 2

Keynote speakers:
- Elly Tanaka (@imbavienna.bsky.social)
- Pavel Tomancak (@mpi-cbg.de)

All other speakers will be selected based on submitted abstracts.

We are looking forward to welcoming you for exciting science in the heart of Vienna, with a special dinner at the Vienna City Hall!

1 month ago 1 0 0 0
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Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you!

www.ezm2026.org

Abstract submission deadline is March 15th.

1 month ago 27 16 3 3

How does the piRNA pathway solve the self vs. non-self problem? ๐Ÿงฌ

Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

2 months ago 91 51 2 4
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Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! #scdb26

@flybase.bsky.social @zfinmod.bsky.social @alliancegenome.bsky.social @insdb.bsky.social @isdb.bsky.social @geneticssociety.bsky.social @bsdb.bsky.social @ascbiology.bsky.social

scdb2026.sites.ucsc.edu

2 months ago 15 10 0 2
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Switching fields or wanting to become an expert in #zebrafish research?
The @mblscience.bsky.social 2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!

Application deadline: March 2

Please spread the word!

www.mbl.edu/education/ad...

2 months ago 28 30 0 4
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Thinking about EZM2026 in Vienna? ๐ŸŸ
Travel grants are now open for students & ECRs.
7โ€“11 July 2026 | Deadline: March 15
Hope to see many of you there! @ezsociety.bsky.social #zebrafish

2 months ago 11 10 0 0
Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids This EMBO Workshop explores the gene-regulatory mechanisms that drive developmental reprogramming upon fertilization. It focuses on the interplay of transcriptional, post-transcriptional, and developโ€ฆ

Still one week to register: meetings.embo.org/event/26-awa...
Come to Seville! It will be super fun!

2 months ago 2 1 0 1

Mark your calendars for 2027! The best GRC is coming to Europe ๐Ÿ‡ณ๐Ÿ‡ฑ

๐Ÿ’ฅ Fertilization and Activation of Development
๐Ÿ“ Noordwijk, Netherlands
๐Ÿ—“๏ธ July 31 - August 6, 2027

www.grc.org/fertilizatio...

Canโ€™t wait!

2 months ago 12 3 0 1
In vivo kinetics of protein degradation by individual proteasomes Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.

New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.

www.biorxiv.org/content/10.6...

3 months ago 47 15 1 2
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๐ŸงชScientists from our Haselbach lab captured how proteins begin to fold as theyโ€™re being made.

Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6

3 months ago 51 16 1 1

If you are interested in #ubiquitin related topics (Who isnโ€™t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!

3 months ago 19 4 0 0