Happy about our new paper in Nature rdcu.be/eukUB
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Hopkins researchers use cryoEM microscopy to advance understanding of glutamate AMPA receptor action. Article link: www.oneneurojhu.org/2025/04/02/b...
Today!!! Support our trainees!! Register here: us02web.zoom.us/webinar/regi...
Congrats!!!
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org for link and infos. See you there!
#ionchannel #WSCS
Needed a break from the anti-science, anti-NIH administration. Dingle peninsula in Ireland.
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!
Direct visualization of electric-field-stimulated ion conduction in a potassium #ionchannel - Cell https://buff.ly/3WfbsLe
Our January issue is here ✨ https://buff.ly/3DFIr4N The cover shows agonist-induced #ionchannel opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He & @lwollmuth.bsky.social (https://buff.ly/3W6IQ6J
The Neurobiology Division at the MRC LMB is looking for a new group leader:
www.nature.com/naturecareer...
I always said that I will not win a Nobel Prize because I like to drink. Well there goes that theory.
There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin!
See details here: opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre.
Please share!
Grateful for having contributed to this work by the Isabelle Baconguis group, who solved eleven (!) new structures of hASIC1a to show that open states require linear transmembrane helices, while desensitized states display a dazzling structural diversity
www.biorxiv.org/content/10.1...
#ionchannels
Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS! #ionchannels #Nav
A good reason to bring out the brown alcohol. A former UG/MS student in the lab (far left. Now MD/PhD at Albert Einstein) stopped by for random visit. Others made the bad decision to work in my lab. Always fun.
So receptors with only Glutamine (Q) present are permeable to potassium and sodium about equally well, and they actually prefer calcium. We show this in the preprint, others like @lwollmuth.bsky.social have shown this.
dx.doi.org/10.1113/jphy...
12/n
At McGill visiting Derek. Wonderful science here. Lots of synaptic physiology. Very elegant. #iglur. #ionchannels
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)
Looks fantastic!!! Jealous of the resolution.
TRPM8 #ionchannel mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons | Neurology Genetics
More from Waxman!
HT @rohacstibor.bsky.social
www.neurology.org/doi/10.1212/NXG.00000000...
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on www.sodiumchannelseminars.org. Mark your calendar and join in! #ionchannels #WSCS
Join the LMB's PhD programme! Applications now open for October 2025 Deadline 3rd December 2024
Considering a PhD in molecular biology?
There’s still time to apply to join the LMB in October 2024.
Applications close on 3rd DEC.
Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...
One for the Thanksgiving dinner table. 🦃
Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
This is a wonderful paper with a ton of difficult single channel measurements on NMDA receptors in non-equilibrium conditions. Fundamental information, presented without hype and with care.
#iGluR
#ionchannels
I am a slow learner. Still trying to figure out posts.
doi.org/10.1085/jgp....
@jgenphysiol.bsky.social
Also the experience at JGP was fantastic. Several reviewers really had incredible suggestions that were very helpful.
