March Genomics Preprint Club meeting is taking place this Friday, March 27 at 3pm EST!

Happy New Year! 🎉 The Genomics Preprint Club is kicking off 2026 with our January meeting this Friday, Jan 23 at 3pm ET.

Looking forward to a great discussion

Join us!

Our December Genomics Preprint Club meeting will take place this Friday, December 12 at 3pm EST!

Figure 1. AlphaGenome expands DeepMind’s biology toolkit, including AlphaFold, AlphaFold 3, AlphaMissense, and AlphaProteo, advancing molecular insights from DNA to protein.

A new preprint Spotlight from @genomicspc.bsky.social is live!

"AlphaGenome: a Swiss-army knife for exploring non-coding DNA"
by Judit García-González & Krzysztof Gogolewski

"Deciphering the three billion letters of the human genome has long been biology’s ultimate puzzle..."

shorturl.at/qiCIk

Contact us via www.genomicspreprints.com/contact.html (or just comment here)

Inferring gene-regulatory networks using epigenomic priors We show improved accuracy of inference of gene-regulatory network (GRN) structure, resulting from the use of an epigenomic prior network. We do so by re-analysing 12 datasets from 12 different studies...

2️⃣ www.biorxiv.org/content/10.1...

EnhancerDetector: Enhancer Discovery from Human to Fly via Interpretable Deep Learning Enhancers are essential non-coding DNA elements that regulate gene expression, yet their accurate identification remains a major challenge. We introduce EnhancerDetector , a convolutional neural netwo...

1️⃣ www.biorxiv.org/content/10.1...

🌍 We are excited to launch the European genomics #preprint club!

Two preprints to discuss tomorrow:

1️⃣ EnhancerDetector: Enhancer Discovery from Human to Fly via Interpretable Deep Learning

2️⃣ Inferring Gene-Regulatory Networks Using Epigenomic Priors

Contact us if you are interested in joining.

🧬 Our October Genomics Preprint Club is next Fri, Oct 31 @ 3pm EST!

Bryce Rowan will lead the session with two great preprints on psychiatric genetics:
1️⃣ Engchuan et al. 2025 shorturl.at/yJ5zx
2️⃣ Shanta et al. 2025 shorturl.at/6GQhD

Join us if you love #Genomics + #preprints!

Figure 1. Novel methods addressing the challenge of multi-ancestry individuals.

A new preprint Spotlight from @genomicspc.bsky.social is now live!

"Advancing methods for multi-ancestry genomics"
by Lathan Liou & Christa Caggiano

authors.elsevier.com/a/1lxdMcQbJF...

The Genomics Preprint Club (www.genomicspreprints.com), led by early-career researchers from our department, is rethinking peer review in #genomics. By critically evaluating preprints, they’re shaping the future of scientific publishing. #GenomicsPreprintClub #ECRvoices bsky.app/profile/geno...

📢 Join us this Friday at 2pm ET for our next Genomics Preprint Club meeting! Chia-Hsuan Chou and Sonali Gupta will discuss two exciting preprints about disease etiology and risk prediction 🧬📊🔬

🚀 Have you tried #AlphaGenome yet? We’d love to hear your first impressions!

👉 Share your thoughts with us, either via DM or at genomicspreprintclub [at] gmail.com

#Genomics #Preprints #Bioinformatics #GenomicResearch #OpenScience

Figure 1. Diversity and size of major global biobank cohorts.

A new Genomics Preprint Club (@genomicspc.bsky.social) Spotlight is now online!

"Unraveling immunity: insights from biobank-scale data"
Chad H. Hogan & colleagues

FREE till Sept. 26 with this link:
authors.elsevier.com/a/1lZUN_3rsx...

Looking for a good weekend read?

www.cell.com/trends/genet...

Check out this @cp-trendsgenetics.bsky.social Spotlight on #methylation clocks -a sharp and accessible piece by Selina Wu and Jennie Chen! Great overview of the current state and future potential of biological age estimation.

📚 Read our new spotlight in Trends in Genetics! Selina Wu, Gita Pathak, and Zhangying Chen discuss the need for improved equity in methylation clocks highlighted in a recent preprint: www.sciencedirect.com/science/arti...

Psychiatric disorders: teasing apart genetic similarities and differences Given the high comorbidity between psychiatric disorders, previous studies have focused on genetic factors shared across the disorders. In a recent pr…

🎉 Our newest spotlight is out now in Trends in Genetics!

"Psychiatric disorders: teasing apart genetic similarities and differences" by Jiayi Xu (@xujiayi.bsky.social) & Laura Huckins (@laurahuckins.bsky.social)

Read more here! www.sciencedirect.com/science/arti...

🧬 New Preprint Reviews Out Now! 🧬

After last week’s Journal Club, our two most recent reviews are now up!

Learn more about a trans-ancestry T1D PRS in Krzysztof Gogolewski’s review & the genetic architecture of allergic diseases in Arnav Wadhawan’s review here: genomicspreprints.com/reviews.html

Hello, There appears to be a typo in the email — it should be judit.garciagonzAlez@mssm.edu

Thank you!

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

Informational flyer for next GPC meeting on Friday, June 27 from 3-4pm EST.

📣 Hello Bluesky! We’re hosting our June Genomics Preprint Club meeting this Friday, June 27 from 3–4pm EST!

📩 Contact us to join!

🗣️ Presenters:
- Krzysiek Gogolewski: www.medrxiv.org/content/10.1...
- Arnav Wadhawan: www.medrxiv.org/content/10.1...

📣 We’re thrilled to share this Q&A about the Genomics Preprint Club—why we started it, how we evaluate preprints as a community, and what we hope it can grow into.

Thanks to Trends in Genetics for highlighting our approach to rethinking peer review through open discussion and shared curiosity.

Figure 1. Epigenetic and multi-omic clocks in aging biomarker development.

Our first preprint Spotlight is now online!

"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)

It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.

Read here:
authors.elsevier.com/a/1lHcdcQbJF...