We have an exciting new story out at @science.org's Science Immunology! It is all about using #AAV-mediated cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse
www.science.org/doi/10.1126/...
Posts by Siegenthaler Lab
This story started during the COVID pandemic. Our first Cambridge PhD students joined during lockdown, and a talented student, @drntombizodwa.bsky.social, wanted to work on a potential therapeutic. Only essential people (James Dooley, not me!) could be in the lab, but they started on the problem
CIPRES is shutting down at the end of June: www.phylo.org .
It's been such a good resource for the phylogenetics community. Thanks to #NSF and Simons for funding it and for all the people who have worked to grow and sustain this for so long.
I am hiring a postdoc for scRNA-seq research in Lund, Sweden on the visual systems of non-model inverts as part of an ERC project on the evolution and ecology of advanced color and polarization vision. Apply here or share the link with someone who may be interested! 🧪
lu.varbi.com/en/what:job/...
Registrations are open for the Development & Cancer course at Institut Curie, dedicated to the most current knowledge linking #devbio with cellular and molecular study of cancers.
📅 September 28th-Oct. 1st, 2026
⏳ September 15th, 2026
🔗 Register: training.institut-curie.org/courses/deve...
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.
My lab is going to print these words and staple them to my forehead.
DNAharvester's workflow.
We present DNAharvester 🎉🦴🚜🧬
A pipeline to process highly degraded ancient DNA data that integrates metagenomic filtering, competitive mapping, multiple alignment strategies, reference bias evaluation and much more.
GitHub: github.com/NBISweden/DN...
Preprint: www.biorxiv.org/content/10.6...
Microbiota-derived ergothioneine counteracts antipsychotic-induced cognitive impairment @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
Screen shot of the sun safety kit bag with all the samples on the label
Screen shot of all the sample bottles
This Set Contains: - 0.33 oz/ 10 mL Lancome UV Expert Defense 50+ Sunscreen - 0.17 oz/ 5 mL Peter Thomas Roth Water Drench Broad Spectrum SPF 45 Hyaluronic Cloud Moisturizer - 0.33 oz/ 10 mL Sofie Pavitt Face Screentime Hydrating Non-Comedogenic Sunscreen, Broad Spectrum SPF 30 - 0.015 oz/ 0.5 mL Tatcha The Silk Sunscreen - 0.68 oz/ 20 mL Tower 28 Beauty SOS Faceguard Broad Spectrum SPF 30 Sunscreen - 0.5 oz/ 15 mL Ultra Violette Sheen Screen SPF 50 Hydrating Lip Balm - 0.5 oz/ 15 mL Ultra Violette Future Screen SPF 50 Modern Mineral Skinscreen - 0.33 oz/ 10 mL Beauty of Joseon Day Dew Sunscreen Lightweight SPF 50 - 1 oz/30 mL Biossance Squalane + Daily Mineral Sunscreen SFP 50 - 0.24 oz/ 7 mL Dermalogica Dynamic Skin Recovery SPF 50 - 1.69 oz/ 50 mL Glow Recipe Watermelon Glow Dew Shield Hydrating Fluid SPF 30 Sunscreen PA+++ - 0.33 oz/ 10 mL innisfree Daily UV Defense Sunscreen Lotion Broad Spectrum SPF 50+ PA++++ - 0.34 oz/ 10 mL ISDIN Fusion Water Magic - 0.5 oz/ 15 mL Kiehl's Since 1851 Better Screen UV Serum Broad Spectrum SPF 50+
Heads up: the Sephora sun safety kit releases today. For $40 you get an assortment of fancy face sunscreens which is a great deal and all proceeds go to @mskcancercenter.bsky.social for melanoma research. Protect yourself from cancer this summer! www.sephora.com/product/sun-...
Malaria may cause long-term brain damage, according to a study that followed nearly 1000 children in Uganda for up to 15 years after their infection. scim.ag/4ex3Jlu
AP: Southern Poverty Law Center says it’s the subject of a criminal investigation by DOJ and faces possible charges over its past use of paid informants to infiltrate extremist groups. They made the announcement, saying Trump admin appears to be preparing legal action against it & its employees.
Figure showing number of competitive grants mentioning women from 2015-2025. The number was rising until recently, with a precipitous drop in the last year.
At the end of 2024, the National Academies put out a report concluding the NIH has woefully underfunded women’s health research, and they suggested $15 B should be invested over the next 5 years.
Here’s what’s happened instead. Hard to study women’s health if you can’t say “women.”
wapo.st/4euUt1c
An open luggage full of scientific books, mostly about zoology, human and primate evolution and anatomy.
Once again, packing all my #books 📚 because yet another postdoc ended and I couldn't secure a permanent position. It might seem adventorous but it's also emotionally exhausting. This is #science too 🧪 A side we don't usually focus on because is not as glamorous as new discoveries.🧵 (1/3)
2016: MSc student at Universitat de Barcelona
2026: back to share my work with the neuroscience community
Full-circle moment. Science can be pretty amazing!
June can’t come fast enough 🧠
The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!
Out today in Nature: rdcu.be/fdC2A
@uclbrainscience.bsky.social
Nice to share our latest paper with you. In this article we set out to measure the age of platelets in circulation. We related storage age (time in storage) to chronological age.
www.tandfonline.com/doi/full/10....
Excited to share a new review by @kocherlab.bsky.social and me:
Nature-inspired neuroscience
We discuss diverse sensory systems and behaviors across the animal kingdom and argue for their integration into neuroscience. New tools in diverse systems are making this possible ✨
tinyurl.com/y5y9du27
From “The Simpsons” house genius John Swartzwelder, interviewed in The New Yorker by Mike Sacks
As described, my linocut shows two blue mussel shells in blue and black ink on 8” x 8” Japanese paper. Numbered 9/12. Titled ‘Blue Mussels.’ Signed Ele Willoughby
My linocut shows 2 blue mussel. The blue mussel (Mytilus edulis), or common mussel, is a medium-sized edible marine bivalve mollusc in the family Mytilidae. They are aptly called common mussels and are found on temperate beaches worldwide. 🧵
Great news from the lab - we’ve been awarded a MIRA (R35)!
This grant provides 5-year support for our research program. We are very grateful to NIGMS/ #NIH for supporting our research. We will be hiring a research technician and a postdoc.
fernandez.lab.indiana.edu/news/index.h...
"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."
Ellen was one of my grad school professors.
For all of the comments in the thread reflecting on her genuineness through their experiences with her on social media, please know that genuineness was also just as true in real life.
Sad day for the #zebrafish community 😔 Our thoughts are with loved ones.
To any that knew Ellen in the #DevBio community- you know she was so thoughtful and always willing to help. She cared about all of us and dedicated herself to improving the future of science and our community. She will be sorely missed. Sending my condolences to all that loved her.💔
Oh my goodness, I am so sorry for your family's loss - I only knew Ellen through social media but her posts about teaching, her undergraduate mentees and their research, her lovely cats were all delightful & insightful. She was a real one & will be missed. ❤️💔
I'm very sorry to tell you that Dr. Ellen LeMosy passed away after a short illness this past Thursday.
This is her sister. Ellen will be sorely missed.
Blurry picture (real) of a horse floating through the air
on my way to get a second ice coffee
I put this together for myself as a Christmas present and hung them up Jan 2025...I suspected I would need some daily inspiration from the 'good doctors' - good grief was I correct! 🫣
WOOHOO! Congrats! 🎉