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Posts by Lorenzo Pasquali

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#JobOffer
MELIS is looking for a Junior Group Leader Position in Cell Metabolism
โœ… PhD in Biology or similar; capacity to lead high-impact research projects; supervision of doctoral theses; teaching
โฐ Deadline: May 2
๐Ÿ“ Barcelona #PRBB
Apply: apply.interfolio.com/180316
Details: bit.ly/40N09LX

1 month ago 7 8 0 3
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Islet Study Group Conference 2026 The Islet Study Group (ISG) Conference is a leading international forum dedicated to advancing islet biology and diabetes research.

Registrations and abstract submission for the 2026 ๐—˜๐˜‚๐—ฟ๐—ผ๐—ฝ๐—ฒ๐—ฎ๐—ป ๐—œ๐˜€๐—น๐—ฒ๐˜ ๐—ฆ๐˜๐˜‚๐—ฑ๐˜† ๐—š๐—ฟ๐—ผ๐˜‚๐—ฝ #EISG2026 are NOW OPEN

Looking forward to seeing you in ๐—•๐—ฎ๐—ฟ๐—ฐ๐—ฒ๐—น๐—ผ๐—ป๐—ฎ!

tacticsmd.net/congreso/isl...

2 months ago 3 1 0 0
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Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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๐Ÿฅณ our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaรฑo-Dรญez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

3 months ago 56 29 6 5

Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds.

Please spread the word!

5 months ago 8 7 0 0
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We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details ๐Ÿ‘‡

5 months ago 16 14 0 0
Helmholtz Munich Receives Funding from la Caixa Foundation to Develop Regenerative Diabetes Therapy

Helmholtz Munich Receives Funding from la Caixa Foundation to Develop Regenerative Diabetes Therapy

#HelmholtzMunich Receives Funding from la Caixa Foundation to Develop Regenerative #Diabetes Therapy
t1p.de/ew4iy

Focus: Developing stress-resistant beta cells
Goal: Overcome immune rejection & enhance #CellReplacementTherapy

@heikolickert.bsky.social @lorenzpasquali.bsky.social

1 year ago 1 2 0 0

Still time to apply!

Applications from US welcome โ€“ four years can feel longer or shorter depending on where you are ๐Ÿ˜‰

1 year ago 13 13 0 0
Postdoctoral scientist, gene regulatory mechanisms and diabetes | CRG Online Recruitment Portal The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

๐Ÿ“ฃ Hiring, please forward widely!!

Two postdoc openings to work on genomics of diabetes

1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling

DM if interested

@crg.eu

shorturl.at/O3wMi

shorturl.at/ieyZy

1 year ago 6 16 1 2
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๐Ÿšจ๐Ÿšจ๐Ÿšจ

If you're a bioinformatician who loves:

๐Ÿงฌ #SingleCell #LongReadSequencing & #AlternativeSplicing
๐Ÿš€ Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! ๐Ÿ™

1 year ago 25 28 0 1
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Long-term inย vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion inย vitro and genera...

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineagesโ€. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

1 year ago 43 15 1 0
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Inceptor binds to and directs insulin towards lysosomal degradation in ฮฒโ€‰cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Thrilled to share one of our biggest discoveries: โ€œInceptor binds to and directs insulin towards lysosomal degradation in beta cellsโ€.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

1 year ago 130 53 6 5
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1/ ๐Ÿงฌ Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dimโ€™s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces.
biorxiv.org/content/10.1101/2024.11.06.622266v1

1 year ago 137 37 3 2