We've spent the last year building something at @humantechnopole.bsky.social that we think is genuinely needed: #AI that works across biological scales and data modalities, not just within them. A thread on what we're doing, why, and who we're looking for. A 🧵... 1/9
Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!
www.biorxiv.org/content/10.6...
Congrats!! Had lots of fun animating all of these beautifuk data!
There was so much to unpack with this data, we teamed up with the marvellous @margotriggi.bsky.social to help explain what we think is going on. (Please also check out our model of central apparatus assembly here: www.biorxiv.org/content/10.6...)
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Lots of fun working on this project! Looking forward to see more and more animations published in the future!
I'm so honored to receive the 2025 Bruce Alberts Award for Excellence in Science Education. Thank you @ascbiology.bsky.social and I look forward to this year's annual ASCB meeting in Philly!
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
What a fantastic ESCRT meeting, the field is going strong and full of exciting science. Many thanks to @rouxlab.bsky.social @cellarchlab.com @jujumathieu.bsky.social @magromayor.bsky.social @majarad.bsky.social for organising such a a great event
Listen to @jiwasa.bsky.social @learngenetics.bsky.social @uofubiochem.bsky.social and Tim Lee @nhmu.bsky.social @utah.edu on @scifri.bsky.social talk about the forms #SciComm can take - why, how, impact
How 'Science Interpreters' Make Hidden Science Visible www.sciencefriday.com/articles/sci...
Thanks to @natsmb.nature.com for interviewing on our work: “seeing biomolecular condensates with computation”
www.nature.com/articles/s41...
Paper Published: A new chapter for Molecule of the Month
Read how @jiwasa.bsky.social has taken over as the series creator of stories about critically important biological macromolecules
pubs.aip.org/aca/sdy...
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
Had a great time chatting with Flora Lichtman and Tim Lee @nhmu.bsky.social a couple of weekends ago here in SLC, and excited that our Science Friday @scifri.bsky.social piece will be airing today! www.sciencefriday.com/segments/sci...
Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
The @briggsgroup.bsky.social alongside teams from @uniheidelberg.bsky.social and @yalemicropath.bsky.social uncover elusive role of #HIV-1 component SP2. Detailed 3D views of viruses by #cryoEM show how SP2 helps the virus matrix to mature.
❕Read the paper @nature.com www.nature.com/articles/s41...
