Every senator who voted to confirm RFK Jr owns this tragedy. Every single one.

A non-monotonic code for event probabilityin the human brain. Nature Communication, Foucault et al, 2025

Using 7T fMRI, our team found a representation of the probability of the next event in human dlPFC —and it’s highly non-monotonic.
Confidence signals, in contrast, were mostly monotonic.

doi.org/10.1038/s414...

🧠🟦🧠🤖

Thank you Nicole!

Nicole's wonderful book 'Elusive Cures' has played an important role in pushing me out of my comfort zone and join forces w/ @philippedomenech.bsky.social and @bellecguill.bsky.social, here.

Exciting times ahead for neuroscience.

Go read it, if you haven't yet!

Graphical summary of the paper entitled : "Macaque prefrontal cortex integrates multiple components for metacognitive judgments of working memory"

Using calcium imaging in macaque PFC during a meta–WM task, we show that PFC jointly encodes remembered locations + uncertainty.

PFC integrates WM strength + cues into a meta-WM signal that guides behavior.

A collab btw our team and Liping Wang group

doi.org/10.1016/j.ne...

🧠🟦🧠🤖

Postdoc position in Paris: come help develop new generation human brain computer interfaces ⚡🧠💻

Interested? Contact me if you have experience with machine learning (e.g. simulation-based inference, RL, generative/diffusion models) or dynamical systems.

See below for + details and retweet 🙏

🚨 !!! New preprint !!! 🚨
MULTIMODHAL (phase 3, multicenter double-blind RCT): fMRI “symptom-capture”–guided neuronavigation significantly improves 1-Hz rTMS outcomes for drug-resistant auditory verbal hallucinations vs standard T3P3 targeting. 🧠🟦

#rTMS #Psychiatry #Schizophrenia #fMRI

Tuberculosis still kills around 1.3 million people every year.

It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?

Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...

U.S. to Review Social Media Posts of Student and Scholar Visa Applicants

Les visas des chercheurs, des universitaires et des étudiants pour les Etats-Unis ne seront pas accordés à celles et ceux qui ont exprimé de l'hostilité au régime autoritaire de Trump. Ces refus de visa se feront par analyse des posts sur les réseaux sociaux.
www.nytimes.com/2025/06/18/u...

Derrière la grave pénurie française de médicaments psychotropes, une défaillance industrielle Plus de la moitié des pharmacies disposent de moins d’un jour de stock de traitements-clés pour les personnes bipolaires ou en dépression. L’arrêt à l’automne 2024 d’une usine grecque qui fabrique, po...

www.lemonde.fr/economie/art...

photo of a girl sitting in an airplane, working on her laptop and wearing headset. A sheet of paper hide her face and reads : "please do not talk to me. I have no self control + will talk to you the whole flight + I have to finish this paper. Thank you"

Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism - Nature Communications Deep brain stimulation of the basal ganglia restores cognitive flexibility and rebalances exploration disrupted by NMDA receptor antagonism in nonhuman primates, offering insights into the neural basi...

This is fantastic, causal work demonstrating the basal ganglia’s role in explore-exploit decision making www.nature.com/articles/s41...

Year ago, the prevailing attitude was that deep learning would significantly improve polygenic risk scores (or anything else, to be fair).

A rather important set of negative results indicating that isn't the case (though I imagine many will still try).
nature.com/articles/s41...

Behavioral, computational and self-reported measures of reward and punishment sensitivity as predictors of mental health characteristics - Nature Mental Health Reinforcement learning task-based behavioral and computational measures displayed low test–retest reliability at the individual level. Also in contrast to self-assessed personality measures, behaviora...

New in Nature MentalHealth! with Vrizzi, Najar, Lemogne, and @mael-lebreton.bsky.social

We tested whether behavioural and RL-based model parameters are test-retest reliable and predict mental health traits.

The result? Not really.

A cautionary tale for comp. psychiatry
doi.org/10.1038/s442...

New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al:

Cycling on the Freeway: The perilous state of open-source neuroscience software

doi.org/10.1162/imag...

#OTD 1920 Edward Kaplan b (d 26 Sep 2006) Best known for 1958 "sleeper hit" paper describing what is now known as the Kaplan–Meier product-limit statistic for survival & lifetime data. Now one of the most cited statistics papers of modern times, it took >12 yrs to catch on. 🧵/6

$500 million is… less than 1.25% of the NIH’s 2024 budget.

When I say there is no capacity to absorb the shock, I mean it.

PhD Timeline xkcd.com/3081

‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.

Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.

Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US This study estimates the number of cases and complications in the US under scenarios of declining childhood vaccination for measles, rubella, poliomyelitis, and diphtheria.

New study in JAMA. Modelling shows that at current state-level vaccination rates, measles may become endemic again in the USA. If rates continue to decline, ditto for rubella, poliomyelitis and diphtheria, leading to many preventable hospitalisations and deaths.
jamanetwork.com/journals/jam...

Thrilled to share our state-of-the-art method for in vivo cell-type classification and brain region localization, NEMO, which is now now a spotlight at @iclr-conf.bsky.social !

We use NEMO to characterize the electrophysiological diversity of cell-types across the entire mouse brain. 🐭 🧪 🧠

U.S. attorney demands scientific journal explain how it ensures 'viewpoint diversity' The unusual letter caught the attention of First Amendment groups and some scientists, who raised concerns it was designed to suppress academic and scientific freedom.

Such a dangerous idea.

US attorney demands scientific journal explain how it ensures 'viewpoint diversity' www.nbcnews.com/science/scie...

Process of science – a human endeavour – full of biases. Key to recognize & counter.

But can’t let false balance & middle ground fallacies taint research.

Trump proposes massive NIH budget cut and reorganization Will Republican-led Congress support a 44% decrease for world’s largest medical research funder?

Trump proposes massive NIH budget cut and reorganization
www.science.org/content/arti...

EU to double funding to attract US scientists fleeing Trump The European Commission acknowledges its interest in the ‘opportunity’ generated by the cuts and obstacles promoted by the Republican administration

english.elpais.com/internationa...

First global pandemic treaty agreed — without the US The World Health Organization accord promotes sharing scientific data in exchange for more equitable distribution of drugs and vaccines.

The world now has a plan for when the next global pandemic hits

https://go.nature.com/43X27wg

My first Saturday morning coffee on my deck this season 😎☕️

Emmanuel Macron appelle les chercheurs internationaux à « choisir » la France et l’Europe, avec un « rendez-vous le 5 mai » Avant ce rendez-vous, une plateforme baptisée « Choose France for Science » a été lancée jeudi par le gouvernement. Il la présente comme « une première étape pour préparer l’accueil des chercheurs int...

www.lemonde.fr/sciences/art...

Accueillir les chercheurs américains en France , « une ambition louable, mais irréaliste » TRIBUNE. L’universitaire Théo Besson rappelle, dans une tribune au « Monde », que le manque criant d’investissement ainsi que le niveau des salaires dans la recherche française interdisent de fantasme...

Intéressante tribune sur l'illusion d'une université française attractive pour les chercheurs américains tentés par l'exil.
Ou de l'incapacité de regarder en face les conséquences de sa propre politique. Terrible absence de sens des responsabilités...
www.lemonde.fr/sciences/art...

A unifying perspective on neural manifolds and circuits for cognition - Nature Reviews Neuroscience Neural manifolds can shed light on how heterogeneous neuronal population activity drives neural computations, but linking these insights to the underlying neuronal connectivity is challenging. Engel a...

"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊

www.nature.com/articles/s41...

Article de Charlie Hebdo

"Quand Nicolas Demorand "révèle" qu'il souffre de trouble bipolaire de type 2, il ne dit rien de son affaire" 😡

En tant que psychiatre, je suis vraiment très en colère à la lecture de cet article de Charlie Hebdo de cette semaine.

Un post n'est pas suffisant pour l'exprimer⬇️

Ten quick tips to get you started with Bayesian statistics

Tips for getting started with Bayesian statistics dx.plos.org/10.1371/jour...