Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...

Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...

Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj

SCLC has tremendous plasticity but genetic events constrain it. Tour de force from @abireland.bsky.social
& special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in #SCLC cancer @nature.com @dukeu.bsky.social @tgoliver.bsky.social @abireland.bsky.social
www.nature.com/articles/s41...

Our lab frequently used BioRender to aid our grant submissions and publications—simplifying complex mechanisms of tumor evolution into beautiful schematics! Here is an example in one of our winning grants. #BioRenderForGrants

The basal cell begets SCLC!
@abireland.bsky.social

Spread the word, mark your calendars, and check for your local rally information!
Raleigh, NC — State capitol — 12-4pm. #standupforscience2025

Devastating for scientists and their research, and everyone who benefits from that research.

I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.

Say it with me. They can regulate our words in a document, but they cannot regulate our thoughts, values, attitudes or behavior. Together, we make up nearly 50% of the population. The economy grinds to a halt without us.
Say it with me.

This has changed the way we think about #SCLC. Big thanks to all who made it possible, especially the one and only @tgoliver.bsky.social. 🥳

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lun...

Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...

Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because: