Mammography should include artificial intelligence support In the past decade, deep learning has increasingly been applied to medical image interpretation, but without consensus as to whether medical practice should change. Many studies show artificial intelligence (AI) enhanced accuracy beyond the performance of radiologists. The most compelling evidence comes from the follow-up of the Mammography Screening with Artificial Intelligence (MASAI) randomised trial, which assessed the reading of two radiologists compared with one radiologist plus an AI algorithm.

Every mammogram should be supported by 3 different AIs for improved detection of cancer, prevention, and risk of heart disease. At no cost to patients.
My new @thelancet.com essay reviews the evidence and the lack of implementation
thelancet.com/journals/lan...

How diverse is bacterial immunity ?

We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...

Explore them here defensefinder.mdmlab.fr/wiki/refseq_...

Interspecies interactions drive bacterial proteome reorganization and emergent metabolism - Nature Ecology & Evolution An analysis of the responses of 15 diverse human gut bacteria in more than 100 pairwise co-cultures reveals extensive remodelling of the bacterial proteome and metabolome in response to the presence o...

Check out our new paper applying fast DIA proteomics to bacterial co-cultures at scale. www.nature.com/articles/s41...
@kiranrpatil.bsky.social

Commentary @cp-cancercell.bsky.social
@crick.ac.uk @naomiirisvdberg.bsky.social
Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity
www.cell.com/cancer-cell/...

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....

I am very pleased with our latest paper showing that cells can remember past injury for a long time! Here a simple interpretable AI was used as a discovery tool to pinpoint the DNA code and biological mechanism. Big foundation models failed. www.science.org/doi/10.1126/...

But now you also have tallycal, lettucemeet… ♾️

Private money cannot replace public funding of science Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public…

Private money cannot replace public funding of science www.science.org/doi/10.1126/...

Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice @natmicrobiol.nature.com @bcmfromthelabs.bsky.social
www.nature.com/articles/s41...

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution - Nature Ecology & Evolution Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distin...

#NatMicroPicks

Same destination, different routes 🍄🧫🧪

Following 10,000 generations, parallel evolution occurred in separate yeast species, but took different genetic routes driven largely by transcriptomic and trans‑regulatory differences.

#MicroSky

www.nature.com/articles/s41...

A pilot study of lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell therapy in patients with advanced solid tumors - Nature Communications The majority of adoptive T cell therapy-based clinical studies are based on the ex vivo expansion of neoantigen-specific tumor infiltrating lymphocytes. Here the authors report the results of a pilot ...

Interesting study:

A pilot study of lymphodepletion intensity for peripheral blood mononuclear cell-derived neoantigen-specific CD8 + T cell therapy in patients with advanced solid tumors

www.nature.com/articles/s41...

“Health professionals were not wrong to be concerned about my cancer risk or to offer follow-up investigations. But I wish they had supported me to find ways to live with an elevated risk that went beyond further medical tests and examinations.“

An important patient perspective ⤵️ #MedSky #PedSky

Amazing new paper from @annabiosys.bsky.social’s lab, following the dynamics of a phage infection in B. fragilis with single-cell RNA-seq (MICRO-SPLiT)👇

@isbscience.org

From this side of the fence... it is kind of poorly thought out and will damage our fragile research ecosystem, as there is no promise of additional over-all funding for Tri-Council grant programs. So however well meant, this recruitment program will just strain an already "ready to snap" system.

Your Bioinformatics Tools Need to be AI-Ready If you're not building tools that emit rich data for machine learning, you're wasting your compute.

Nils Homer @nilshomer.com: bioinformatics tools already compute tons of useful intermediate data, then throw it away. Emit structured features by default so ML models and AI agents can use them. The cost of not capturing it is re-running everything later. blog.fulcrumgenomics.com/p/your-bioin...

🔬 New aging model: #Yeast aging pathways proceed independently in parallel, not as mutually exclusive alternatives. "Competing hazards" framework explains how cells age differently based on which process reaches catastrophic failure first
🧪 #YeastResearch 🧬 #SGD
www.yeastgenome.org/reference/S1...

Call for Papers: Microbial Evolution - Impacts on Human Health A defining characteristic of infectious diseases is that they evolve. The consequences of this evolution are among the most pressing medical issues facing human

We are already seeing some great submissions, please join them!

Call for papers: Microbial Evolution-Impacts on Public Health at EMPH, a society journal with a thoughtful and constructive ed board!

academic.oup.com/emph/pages/m...

Even among healthy people, immune systems operate at different baseline levels.

In our new Cell paper, we show that these immune states are stable over time and are associated with the gut microbiome. 🧵
@cp-cell.bsky.social
#Immunology #SystemsImmunology

We might hope for clinical testing to be more standardized than consumer services, but if 7 different companies can’t even begin to reach the same conclusion from the same stool sample, we might have problems trusting microbiome data to inform anything health-related.
www.nature.com/articles/s42...

🧵 See 👇 our new preprint on shared and organ-specific gene expression programs of fibrotic diseases 🧬

📄 Paper: doi.org/10.64898/202...

📊 Explore the data: organfibrosis.saezlab.org

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution Nature Microbiology, Published online: 06 March 2026; doi:10.1038/s41564-026-02286-7Bulk polyadenylation improves the capture of microbial RNA, enabling host–microorganism interactions to be visualized at a high resolution when combined with commercially available spatial transcriptomics platforms.

Out Now! Spatial transcriptomics maps host–gut microbiome biogeography at high resolution #MicroSky

A new preprint with Matthew Schmitt, @kiseokmicro.bsky.social and Vincenzo Vitelli makes a huge step forward in learning functional groups of components in complex biological systems. It's dimension reduction that speaks to biological function. www.biorxiv.org/content/10.6...

Given that clonal biofilms of single bacterial species rapidly diversify into niche specialists, how do biofilms of multiple species evolve?
A 🧵 featuring new collaborative pubs:
1. www.biorxiv.org/content/10.6...
2. www.nature.com/articles/s41...

We recently updated our paper demonstrating evidence of off-target probe binding affecting the 10x Genomics Xenium spatial transcriptomics platform with key clarifications, new quantifications, and approaches for evaluating custom gene panels: biorxiv.org/content/10.1...

🧵👇1/n

Had a wonderful time last week at the From Cells to Ecosystems meeting at the Bellairs Research Institute in Barbados!

Thanks to @vdumeaux.bsky.social and @hallettmiket.bsky.social for the invitation. It was a unique experience that brought together researchers from vastly different disciplines.

Thank you for coming and for your participation throughout the week. The workshop participants are the ones making this a great event! Cheers

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

More hope from mRNA vaccines. In this instance, individualized vaccines were given to women with triple negative breast cancer following surgery and adjuvant therapy. The results are quite remarkable. Despite cancer finding a ‘T cell-evading’ work-around in some patients.
#Science 🧪

Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...

Our latest is out today in @plosbiology.org:

"Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials"

@isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social

doi.org/10.1371/jour...

Culturing microbiome therapeutics with big data www.nature.com/articles/s41...

CIHR funding rate: 13.6%.
Early 2000s: 30%+.

Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system.

We’re calling for $1B over 5 years.
Support here: tinyurl.com/33c5av46

Check out this new & very promising method for differential analysis in microbiomes from @antagomir.bsky.social et al.