Adenosine in the Brain: Recent Progress on Detection, Function, and Translation Although adenosine was identified in the brain many decades ago, our understanding of when, where, and how it functions has expanded rapidly in recent years, driven in part by innovative technological...

Check out our recent review on adenosine. A lot of new discoveries suggesting its tremendous potential in translation, among others, Parkinson's disease and insomnia. www.jneurosci.org/content/45/4...

Neuronal architecture of the mouse insular cortex underlying its diverse functions The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion, learning, and potentially consciousness.[1][1]–[4][2] However, the cellular and circui...

A tour de force study by my colleague Tianyi Mao's lab
@volluminstitute.bsky.social. Must read if one is interested in interoception, the insular cortex, or circuit architecture of associative cortices.
www.biorxiv.org/content/10.1...

A high-performance genetically encoded sensor for cellular imaging of PKC activity in vivo - Nature Communications Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity—a m...

Some issue with the link. This is the correct one: www.nature.com/articles/s41...

‪Glad to share that our CKAR3 sensor for in vivo PKC activity imaging is now out at @natcomms.nature.com. Congrats to the team, especially co-first authors Takaki Yahiro and @baylesslandon.bsky.social.
www.nature.com/articles/s41...

Left to right: Laurence Trussell Ph.D., Natalie Sheldon, Chengli Fang Ph.D., Jumi Park Ph.D. and Eric Gouaux Ph.D.; Cathy Spangler Ph.D. is not pictured.

For the first time, scientists using #cryoelectron microscopy have discovered the structure and shape of key receptors connecting #neurons in the brain’s cerebellum, which plays a critical role in functions such as coordinating movement, balance and cognition. #OHSUResearch bit.ly/4b9gOw9