Toroidal manifolds abruptly emerge at P10 in rat pups! 🤪🍩

Several days later, space is *gradually* anchored to these tori when the puppachino actively navigates

Congrats to the big boss @matteoguardamagna.bsky.social 🤠

🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome!

www.biorxiv.org/content/10.6...

Excited to share our study in Neuron led by
@travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!

Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.

*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️

Graphical visualization of the research question

Your stomach called – your striatum picked up!

But does this actually happen in humans?

Using simultaneous dopamine PET/fMRI, we show that the gut hormone ghrelin helps the brain adjust motivation to current metabolic need.

Here’s what we found👇
Preprint: shorturl.at/pq4A3

#neuroskyence #🩺

Congrats Flavio!! 🩷

🧠📢 New preprint alert

Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵

#neuroskyence #compneurosky

Still at SfN on the last day? During the morning session on the 19th, 8:00AM - 12:00PM, come check out our posters from the Moser, Zong, and Gonzalo Cogno groups in row QQ ('Grid cells and spatially modulated cells'). Ephys, imaging, remapping, development, sweeps and more! 🧠
Detailed thread below 👇

SFN 2025 let’s gooo!!

Moser group posters are held Wednesday morning (QQ), so if you’re leaving early feel free to come find us to chat :)

Congratulations Andy! Looks great 🩷

Thrilled to share that our work is now published in Science! ✨

We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭

www.science.org/doi/10.1126/...

🧵1/

“If everything is everywhere, why have distinct areas? Here we show that the function of a brain area is more related to how different types of information are combined (formatted) in neural representations than merely whether that information is present.”

Direct entorhinal control of CA1 temporal coding Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠

rdcu.be/evWtz

Congratulations Dan!!! 🩷✨

Fragmented replay of very large environments in the hippocampus of bats Hippocampal replays in bats flying in a 200-m tunnel depict short fragments of long flight trajectories, suggesting constraints on the mechanisms and functions of replay.

Amazing study: @tamir-eliav.bsky.social from the Ulanovsky lab describes replay events in a large scale environment (200 m tunnel). 🦇

www.cell.com/cell/abstrac...

(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.

Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...

Global modules robustly emerge from local interactions and smooth gradients - Nature The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.

1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social .
Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇

Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.

handsome boy 💖

Congratulations Abe and Rich!!

We are still taking applications!

Hippocampal neuronal activity is aligned with action plans - Nature Using high-density electrophysiological recordings, how internally generated cell assemblies are updated by action plans to meet external goals is explored.

It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.”
Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals

www.nature.com/articles/s41...

Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of…

Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...

celebrating another year of excellent science, happy animals, and *happy people* at the kavli ❤️✨

@kavlintnu.bsky.social

Do octopuses dream? Brain recordings provide the first clues YouTube video by nature video

Do octopuses dream?
In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible.
youtu.be/006DjAixu9E?...

Let’s go!!!!!! Well deserved 😍

In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate

Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...