Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

Great study and a nicely succinct explanation below!

Gltp ko in mouse is also lethal

Looking for a postdoc - Shi Lab The Shi lab at Rutgers-New Brunswick is seeking a postdoctoral researcher to study biomolecular condensates and/or mechanosensitive membrane proteins. To see more information and apply, please go to t...

We are looking for a postdoc to study biomolecular condensates and/or mechanosensitive membrane proteins. Please help spread the news 🙏
sites.rutgers.edu/shi-lab/look...

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

If you’re in San Diego for #ACSSpring2025, don’t miss our @acsbiol.bsky.social symposium featuring @chembiobryan.bsky.social, Jenn Prescher, & Carsten Schultz on Wed 3/26 from 2-5 pm in Room 31A to hear about awesome #lipidtime #bioorthogonal #chembio #synbio! acs.digitellinc.com/live/34/sess... 2/2

Congratulations!! 🎊

It’s my honor you like the work. Too bad there aren’t any galactose analogs I can use 🥹

However, myelin growth occurs at the innermost layer of myelin wrap-far from and difficult to access from the cell body. This led us to hypothesize that oligodendroglial ER extends into the myelin, allowing lipids to be synthesized locally and delivered directly to myelin (3/n)

As an enthusiast of ER and membrane biology, I find oligodendrocytes fascinating because they are among the human body’s most powerful lipid producers. To generate myelin, each cell must expand its plasma membrane thousands of times. (2/n)

My first-author #lipidtime paper is out
@NatureComms
! We studied how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in mouse developing myelin and explored nonvesicular lipid transport involved doi.org/10.1038/s414... (1/n)