1/ Philipp Mallm from the @dkfz.bsky.social Single-cell Open Lab just broke the news at #AACR26: the first results on colorectal cancer (CRC) tissue analysis with the new Atera spatial transcriptomics platform from @10xgenomics.bsky.social. Is it "making the impossible possible?" 🧵
The impossible is finally here: introducing Atera, uncompromised #spatialbiology that lets you analyze up to 800 1 cm2 whole transcriptome samples/year with #singlecell sensitivity. Impossible breakthroughs await: register now for an in-depth look at our 4/21 webinar. https://bit.ly/4b5SnBx
Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling
www.biorxiv.org/content/10.6...
From #PCR, to #NGS, to #scRNAseq, yesterday’s pipe dream is today’s standard. Science follows a pattern, after all: first, something’s impossible. Then, it’s indispensable. So what’s next on that list?
Join us for a webinar this April to find out. https://bit.ly/4tJv9tD
This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C):
www.nature.com/articles/s41...
A cover of a board book titled “Goodnight Lab” written and illustrated by Chris Ferrie.
A grumpy old professor shouting “publish”
Goodnight to the grumpy old professor shouting “publish”
I got a book titled "Goodnight Lab" for my 5yo, and it is hilarious!
A close-up of a blue ceramic pot containing a variety of small succulents, including a tall, speckled succulent Scilla and a symmetrically stacked succulent Crassula, illuminated by bright sunlight from a window.
Using a pot I got for my birthday, I tried my first group planting of succulents. Not bad.
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Considering the recent significant advancements in scaling laws for LLMs, I believe that similar scaling laws exist in biology and medicine.
Considering the recent significant advancements in scaling laws for LLMs, I believe that similar scaling laws exist in biology and medicine.
Creating the largest #singlecell dataset ever will take dedication, collaboration & high-performance tools. We’re thrilled the @chanzuckerberg.bsky.social Billion Cells Project will pair GEM-X tech with Ultima Genomics sequencing to achieve this landmark scale. Learn more: bit.ly/4aRaScr
ありがとうございます！
age += 1
The image shows a coloring activity by my kid featuring a drawing of Martin Luther King Jr., with the name “Martin Luther King Jr.” written at the top. Below the illustration, the phrase “I Have A Dream” is printed in dashed letters, likely for tracing. The drawing has been colored in with vibrant hues: brown for the face, blue for the suit, red for part of the suit and tie, yellow and green for the tie, and pink for the lips.
Good job, my kid
I recently reconnected with a friend from junior high school, who is now a university professor, and we had an interesting discussion about the characteristics of biology and medicine as disciplines.
The image shows a coloring activity by my kid featuring a drawing of Martin Luther King Jr., with the name “Martin Luther King Jr.” written at the top. Below the illustration, the phrase “I Have A Dream” is printed in dashed letters, likely for tracing. The drawing has been colored in with vibrant hues: brown for the face, blue for the suit, red for part of the suit and tie, yellow and green for the tie, and pink for the lips.
Good job, my kid
As a biologist by training, I understand that recognizing the unique characteristics of each discipline is crucial for efficient learning and progress. This understanding helps avoid unnecessary detours and ensures a more direct path to mastering new fields.
Biology presents a different challenge, as studying higher levels requires a solid understanding of the basics. For example, working in immunology demands more than just memorizing basic biochemistry or genetics concepts; it requires a deeper comprehension of these foundational subjects.
In fields like physics and computer science, a clear hierarchy exists, allowing the use of basic levels without deep understanding. For example, in computer science's statistical mathematics, one applies theorems without needing to prove them. This discernment is crucial given our limited time.
I recently reconnected with a friend from junior high school, who is now a university professor, and we had an interesting discussion about the characteristics of biology and medicine as disciplines.
This photo depicts a whimsical playground or park area with several large, flower-shaped canopies providing shade. The turquoise-colored flower structure occupies the foreground, its petals arranged around a central hub and filtering the sunlight. Behind it stand two more oversized flower shades—one blue and one red—adding vibrant pops of color. Beneath and around these structures is a circular plaza paved with a floral design. There are additional play elements in the background, along with greenery and scattered trees. A few people can be seen walking or playing, while the sky above is partly cloudy with soft light peeking through, giving the scene an airy, spacious feel.
A playground with cool canopies.
A close-up photograph of a Haworthia cooper var. truncate, resembling a cluster of grapes with almost transparent leaf tips.
A new addition to my office desk. Haworthia cooperi var. truncate.
Don’t cook yummy pasta, or they will identify the Earth’s location and destroy our civilization #darkforesttheory #threebodyproblem
Check out a preprint from our lab! We've uncovered all possible speed imager sequences for DNA-PAINT. You can now do 10-plex imaging in just a few hours with simple Exchange-PAINT. 🚀📸 #DNApaint #SuperResolution
www.biorxiv.org/content/10.1...
Reposting my offer for 1-1 mentoring for anyone… email me and we'll find a time! Especially happy to talk with those from diverse backgrounds and non-traditional career trajectories.
(20 + 25)^2 = 2025
Happy New Year!
A panoramic photo of a beautiful sunset from a hill.
Watching a beautiful sunset from a hill. "Daddy and Mommy were born in a country beyond the sunset."
Since it's winter break, I've decided to study the basics of AI, specifically ML and DL. My goal isn't to become a developer; rather, I want to be able to communicate effectively in future research and development settings from a biologist's perspective and quickly understand the key concepts.
