In vitro identification of kainic acid-induced, concentration-dependent responses in human cortical neuronal networks Neuronal networks derived from human induced pluripotent stem cells (hiPSCs) have gained attention for their potential use in studying cellular electr…

Nice collaboration with Susanna Narkilahti’s group at Tampere University now out, showing elevated tRFs in an in vitro hyperexcitation model in iNeurons. @futureneuro.bsky.social @physiologyrcsi.bsky.social www.sciencedirect.com/science/arti...

A multi-step filtering pipeline for human read removal enhances detection of Fusobacterium in WGS datasets with immunohistochemical confirmation in mucinous rectal cancer. The study of tumour-associated microbiomes using whole-genome sequencing (WGS) has attracted considerable attention, but microbial signal detection remains controversial due to host contamination and ...

A new pipeline for detecting Fusobacterium in WGS datasets from our lab with immunohistochemical confirmation just out. www.biorxiv.org/content/10.1...

Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive...

Excellent collaboration with @annagolebiewska.bsky.social delivering humanised glioblastoma patient-derived xenograft models to test novel immunotherapy strategies for brain cancer. www.biorxiv.org/content/10.1...

Big thanks also to Boris Rogelj who acted as extern and gave an excellent talk on RNAs that bind proteins (or was it proteins that bind RNAs 🤔) in ALS and FTD. @physiologyrcsi.bsky.social

Congratulations to Qilian who passed her PhD viva investigating effects of tiRNAs on FUS phase transition in ALS @physiologyrcsi.bsky.social

Delighted for Prof Annette Byrne @physiologyrcsi.bsky.social to be elected as a member of the Royal Irish Academy yesterday for her achievements on cancer research.

Congrats to Batuhan Khisakol and all @physiologyrcsi.bsky.social PhD students who were conferred today!

speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include @epetsalaki.bsky.social @ciriellolab.bsky.social @juliosaezrod.bsky.social @molsysbio.bsky.social @inesthiele.bsky.social @profjochen.bsky.social @renskevroomans.bsky.social +tons more

@heikoimaging.bsky.social presenting work done on Fuso bacterium in CRC together with Barry McGuire and @profjochen.bsky.social et al working @physiologyrcsi.bsky.social in @rcsi.bsky.social

🚨JOB OPPORTUNITY🚨
Post-doc with molecular biology/experimental background to perform spatial and single-cell experiments with @profjochen.bsky.social 's group
🔗 in comment

Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy Objective Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multi...

When chemotherapy may do harm - super plexing of cell death proteins shows that ‘persister’ cells do not benefit from 5-FU based adjuvant chemotherapy in colon cancer bmjoncology.bmj.com/content/3/1/...

24th Annual International Conference on Systems Biology (ICSB 2025) YouTube video by Systems Biology Ireland Official

Delighted to chair the ‘Clinical Decision Support Tools’ session at #ICSB2025 in Dublin, Oct 5-9 youtu.be/i8ekr_KmwvA

@rcsi.bsky.social @physiologyrcsi.bsky.social @rcsi-research.bsky.social

What are the biological functions of stress-induced tiRNAs (tRNA fragments) - we took an unbiased approach exploring an #ALS associated tiRNA www.sciencedirect.com/science/arti... @physiologyrcsi.bsky.social @rcsi-research.bsky.social @mndresearch.bsky.social #ncRNA #MND

Focus on 💪 in ALS: We found a new role for Angiogenin in muscle regeneration with diagnostic implications. onlinelibrary.wiley.com/doi/10.1111/... @mndresearch.bsky.social @rcsi-research.bsky.social @physiologyrcsi.bsky.social @neuroscienceirl.bsky.social #ALSResearch #MNDResearch

Dr Batu! - delighted that @researchireland.bsky.social @genomicscrt PhD student Batuhan Kisakol has passed his viva today- with no corrections! Thanks to examiners @sudiptodas_rcsi and @oncode.bsky.social ‘s JP Medema @rcsi-research.bsky.social @physiologyrcsi.bsky.social 🎉👏🏻🍾🎓

Fully funded MSC PhD positions in AI and Parkinson’s Disease now available, including two positions at @rcsi.bsky.social Apply at .aipd-dn.eu/en/vacancies... @rcsi-research.bsky.social

Congrats to my former MD student Bill Duggan for the @rcsi.bsky.social Postgraduate School 2024 Clinical Research Award for his @gutmicrobes.bsky.social paper on spatial effects of bacterial infection on the transcriptome in colorectal cancer @rcsi-research.bsky.social @physiologyrcsi.bsky.social

Our new manuscript is out showing distinct fingerprints of tRNA fragments during neurodegeneration, led by our SFI CRT GDS PhD student Sharada Baindoor. doi.org/10.1242/dmm....