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Posts by Casey Theriot

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Christina Koch is moon-bound. 🚀🌕 The three-time NC State grad and her fellow Artemis II crew members blasted off from Kennedy Space Center on Wednesday evening. She will see parts of the solar system no human has ever seen before.

Read more: http://ncst.at/uzpN50YC2pl

2 weeks ago 27 5 0 2
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Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!

Only TWO WEEKS left to register for @keystoneSymposia.bsky.social Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection, in Breckenridge!

Check out the lineup of speakers - it is going to be an amazing meeting! Join us in May! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

3 weeks ago 2 3 0 1
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Very provocative new paper in @natmicrobiol.nature.com

As global temps rise, drought is becoming more frequent and prolonged across many regions

Paper shows climate-driven drying of soils can fuel antimicrobial resistance at its ecological source, independent of clinical antibiotic use

🧵 (1 of 6)

4 weeks ago 24 14 2 0
Research Specialist - Theriot Lab The Theriot Lab is seeking a motivated and detail-oriented Research Specialist for a 1 year appointment. This role is ideal for a candidate looking to dive deep into microbiology research, focusing on...

We are looking for a talented research specialist to join our team at NCSU CVM in the Theriot lab! Please take a look and apply if your are interested.
jobs.ncsu.edu/postings/228...

4 weeks ago 0 2 0 0
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Her son needed a fecal transplant for a fearsome C. diff infection. Getting one required a tortuous journey Her son needed a fecal transplant for a fearsome C. diff infection. Getting one required a tortuous journey.

C. difficile is a terrible condition. Seems like it shouldn't have to be this hard to try to treat a child with a bad case of it. www.statnews.com/2026/03/23/c...

4 weeks ago 44 5 1 0

New preprint from the Theriot lab and collaborators, which looks at how strain-dependent bile acid transformations by commensal Clostridia attenuate C. difficile virulence and disease without decreasing colonization!

www.biorxiv.org/content/10.6...

1 month ago 8 4 0 0
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics) YouTube video by KeystoneSymposia

⏰ Last chance to save $250! Register for Beyond Antibiotics by 11:59pm MST on March 5.

Join @joeyzacks.bsky.social, @kimingeneva.bsky.social, @dariavantyne.bsky.social & @maribyndloss.bsky.social to spark new collaborations.

🎥 youtu.be/8Ppjx-MnvxA
keysym.us/KSBeyondAnti...

#KSBeyondAntibiotics26

1 month ago 4 5 1 1
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Mucosal vaccination clears Clostridioides difficile colonization - Nature Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence ...

#NatMicroPicks

C. diff vaccine! 🦠💉

A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.

#MicroSky

www.nature.com/articles/s41...

1 month ago 54 11 0 7
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How a Better Bile Acid Could Keep C. diff at Bay

news.cvm.ncsu.edu/how-a-better...

4 months ago 6 1 1 0
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A Mouse Model of C. diff at NC State is Helping Scientists Around the World Develop Better Antibiotics

Some nice press from a recent international collaboration with researchers from Leiden University.
news.cvm.ncsu.edu/a-mouse-mode...

4 months ago 9 0 0 0
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Nearly 1,000 people have registered so far! Don't miss out!

4 months ago 7 2 0 0

Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model

5 months ago 19 7 0 0
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Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.

#NewResearch

A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.

#MicroSky 🦠💊

www.nature.com/articles/s41...

5 months ago 36 17 0 2
Successful Fecal Microbiota Transplants in Post-antibiotic Treated Recurrent Clostridioides difficile Patients Induce Acylcarnitine and Sphingolipid Lipidomic Shifts Clostridioides difficile infection (CDI) is an urgent public health threat in the United States, resulting on an annual basis in over half a million cases, more than 29,000 deaths, and $4.8 billion in...

Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT.
www.researchsquare.com/article/rs-7...

5 months ago 3 1 0 0
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Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang Het in Leiden ontwikkelde antibioticum EVG7 slaagt erin om met een minimale dosis de gevaarlijke darmbacterie C. difficile te bestrijden. Bovendien komt de bacterie minder gemakkelijk terug, wat bij b...

Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...

6 months ago 2 1 0 0
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Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.

New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...

6 months ago 11 5 1 0
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Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.

Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae.
www.nature.com/articles/s41...

6 months ago 4 0 0 0
About Seeding Postdoctoral Innovators in Research & Education (SPIRE)

SPIRE’s Mission:

1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences

2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students

The four major components of the SPIRE Postdoctoral Fellowship Program include:

Research
Teaching
Professional Development
Additional Opportunities

About Seeding Postdoctoral Innovators in Research & Education (SPIRE) SPIRE’s Mission: 1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences 2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students The four major components of the SPIRE Postdoctoral Fellowship Program include: Research Teaching Professional Development Additional Opportunities

Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n
spire.unc.edu/program-info/

6 months ago 16 23 1 1
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NIH whistleblower details clash over childhood vaccines with Trump administration: "We became inconvenient" A former NIH official says she was removed after clashes over vaccines, accusing RFK Jr. and his deputies of posing "a substantial and specific danger to public health and safety."

"We became inconvenient".

7 months ago 0 1 0 0
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If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.

7 months ago 499 171 3 1
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

8 months ago 60 100 3 4

The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.

8 months ago 12 2 0 0
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A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability.

Hey OMB, see you in court.

8 months ago 441 148 16 28
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I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.

8 months ago 9112 1778 568 598

Thank you Senator Tillis! NC folks drop him an email or make a call and thank him

8 months ago 17 5 0 0

We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.

8 months ago 449 121 11 5
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Enterococcus faecalis modulates phase variation in Clostridioides difficile www.biorxiv.org/content/10.1101/2025.07....

8 months ago 13 7 1 2

I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.

9 months ago 31 7 0 0
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Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment

New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...

9 months ago 20 8 1 1
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Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!

9 months ago 3 2 1 0