Around 40000 people are diagnosed with #TB each year in the EU/EEA & some cases still go 𝘂𝗻𝗱𝗲𝘁𝗲𝗰𝘁𝗲𝗱.

For the World TB Day, we speak with #ECDC's expert Senia Rosales-Klintz about:

➡️ how TB can remain hidden in the body
➡️ what treatment really involves
➡️ why gaps in detection & care still matter.

Our analysis of #TB exposure and transmission patterns is now in @pnas.org. @petedodd24.bsky.social and I found a majority of TB transmission globally is attributable to contact with adult men, while contributions to transmission by age are more variable across regions.
www.pnas.org/doi/10.1073/...

Estimating the global burden of viable Mycobacterium tuberculosis infection: A mathematical modelling study Alvaro Schwalb and colleagues conducted a mathematical modelling study to estimate the global burden of viable Mycobacterium tuberculosis--that which can cause disease and be transmitted--to help guid...

1/📢 In our new publication, we estimate that in 2022, 134 million people worldwide had a recent Mycobacterium tuberculosis (Mtb) infection and were at high risk of progressing to TB disease. Read the full paper in PLOS Medicine (tinyurl.com/mtbinfection). #TBSky

#tuberculosis #modeling #fellowship with lovely & great people at Johns Hopkins (deadline 31 January) drive.google.com/file/d/12lK8...

Global estimates of tuberculosis incidence during pregnancy and postpartum: a rapid review and modelling analysis Despite known maternal, perinatal, and infant health risks of tuberculosis during pregnancy, global estimates of incidence remain scarce. Existing est…

Our new paper highlights a substantial but under-recognized burden of #tuberculosis during pregnancy and postpartum with ~340,000 women affected globally in 2023.
👉 www.sciencedirect.com/science/arti...
#MaternalHealth #GlobalHealth @petedodd24.bsky.social @tb-ipd.bsky.social @lancetgh.bsky.social

A global analysis of patterns of tuberculosis exposure and transmission Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...

Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.

bit.ly/4nbV492

New approaches for modelling tuberculosis transmission in low incidence settings at University of Bristol on FindAPhD.com PhD Project - New approaches for modelling tuberculosis transmission in low incidence settings at University of Bristol, listed on FindAPhD.com

PhD opportunity: New approaches to modelling TB transmission in low-incidence settings.
Supervised by Ellen Brooks-Pollock (Bristol), me (Bath) & Rajeka Lazarus (Bristol)
Apply: www.findaphd.com/phds/project...
Deadline 20 Oct
#PhD #Tuberculosis #Epidemiology #InfectiousDisease

PhD Studentship in Respiratory Electronic Health Record Group: Analysing electronic health records to study pathways of care for people with tuberculosis at Imperial College London on FindAPhD.com PhD Project - PhD Studentship in Respiratory Electronic Health Record Group: Analysing electronic health records to study pathways of care for people with tuberculosis at Imperial College London, list...

#Imperial PhD studentship on #electronicpatientrecords analysis for UK #tuberculosis policy, with Onn Min Kon, Jenni Quint, Sharon Cox at #ukhsa and me. www.findaphd.com/phds/project...

World maps of additional child tb & tb deaths

More projected impacts of cuts to international health aid on paediatric #tuberculosis urldefense.proofpoint.com/v2/url?u=htt...

Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrit...

So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)

@cfmcquaid.bsky.social @tbtakenseriously.bsky.social @jaseddon.bsky.social @petedodd24.bsky.social @tb-lshtm.bsky.social #endtb

The Union's TB Undernutrition working group is hosting a webinar with Dr Matthew Saunders.

📅 21 August at 2pm CET

Dr Saunders (@lshtm.bsky.social‬) will share findings from a new analysis that redefines the relationship between BMI and TB incidence.

📧 To join email membership@theunion.org.

Evaluating the health impact, health-system costs and cost-effectiveness of using TrueNat on stool samples compared to usual care for the diagnosis of paediatric tuberculosis in primary care settings:... The World Health Organisation (WHO) recommends rapid molecular diagnostics to improve bacteriological confirmation of tuberculosis in children. TrueNat MTB, MTB Plus and MTB-RIF Dx assays (Molbio Diag...

Check out our new @PLOSGPH paper exploring the impact and cost-effectiveness of near point-of-care technology for diagnosing #tuberculosis in children in primary healthcare settings. Read it here: doi.org/10.1371/jour... From @petedodd24.bsky.social

Cost-effectiveness of tuberculosis infection screening at first reception into English prisons: a model-based analysis The World Health Organization recommends systematic screening for tuberculosis in incarcerated populations, which are consistently at high risk of tub…

Meeting the health needs of incarcerated people can be costly. We found that targeted #tuberculosis infection screening at 1st reception in England could be cost saving.
www.sciencedirect.com/science/arti...

Treatment decision algorithms for tuberculosis screening and diagnosis in children below 5 years hospitalised with severe acute malnutrition: a cost-effectiveness analysis Children with severe acute malnutrition (SAM) are an important risk group for underdiagnosis and death from tuberculosis. In 2022, the World Health Or…

WHO recommends treatment decision scoring algorithms to help diagnose child #Tuberculosis. Thx to #Unitaid, our TB-Speed team evaluated them to be very cost-effective for children with severe acute malnutrition in UGA & ZAM

www.sciencedirect.com/science/arti...

Thinking fast and slow: the urgency of crisis response must not lead us to overlook chronic needs such as tuberculosis The number of people facing displacement due to humanitarian crises worldwide is increasing rapidly and is likely to continue. An average 10% year-on-year increase in the last 5 years resulted in 68.3...

In 2024, 68 million people were internally displaced by humanitarian crises, & are at increased risk of TB, the world's biggest infectious disease killer. We urgently need estimates to identify the scale of this problem & drive our response. We provide initial numbers here gh.bmj.com/content/10/3...

Tuberculosis treatment

Yes, #Tuberculosis (TB) is curable!

TB is treated with antibiotics taken daily for 4–6 months. ⚠️ Stopping treatment early can lead to drug-resistant TB.

Funding cuts & rising drug resistance put the most vulnerable at risk. Sustained support is crucial to #EndTB 👉 bit.ly/4ilkK1h #WorldTBDay

Quantifying potential immortal time bias in observational studies in acute severe infection We developed a tool to quantify the impact of misallocation of person time, then used it to demonstrate that published observational studies have likely ov

NEW PAPER with @tom-parks.bsky.social and @petedodd24.bsky.social in @ofidjournal.bsky.social

Our tool can estimate extent to which misallocation of person time will result in spurious or optimistic estimates of intervention effects

We find benefits of IVIG in STSS have likely been exaggerated

A tracker estimating TB deaths from USAID funding discontinuation #IDsky #TBsky tb.impactcounter.com

A tracker estimating deaths from freezing PEPFAR pepfar.impactcounter.com #HIVsky #TBsky #IDsky

Caps lock as control fixed me

Opinion | I Shudder to Imagine Kennedy Running Our Health Agencies. We have to go toe-to-toe with this administration and resist its attacks on public health.

Do not accept defeat. We don’t have time for despair.

Read this important piece from one of my heroes @gregggonsalves.bsky.social

We have work to do!

#publichealth #medsky #emedsky #episky #resist #lgbtqSTEM #academicsky

Great article showing impact on Tuberculosis of funding freeze

"Stopping this—literally overnight—means that these strains have the potential to spread not just abroad but here in the US."

#EndTB #keepthelightson #11KEveryDay #RestoreTBFunding

New preprint (with all pre-print caveats!) tinyurl.com/589ffhu4 on Mtb infection risk by sex & age.
Men are at higher risk of #tuberculosis v women- but unclear how much driven by higher infection vs progression to disease. We meta-analysed Mtb immunoreactivity surveys to find out more🧵 #tbsky

NEW PREPRINT!

Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias

In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment

www.medrxiv.org/content/10.1...

[1/n]

This is the levofloxacin TPT Xmas double issue #TBsky

Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis | NEJM Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately 30...

Here is the article and link (making sure it gets embedded): doi.org/10.1056/nejm...

#idsky #tbsky

Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa: the INPUT stepped-wedge cluster-randomised trial Introduction Paediatric tuberculosis (TB) underdiagnosis is a critical concern. The INPUT stepped-wedge cluster-randomised trial assessed the impact of integrating child TB services into child healthc...

Newly out RCT data on integration of child TB services into routine care in KEN/CMR gh.bmj.com/content/9/12... #TBsky & our economic evaluation of it: gh.bmj.com/content/9/12...

Global burden of tuberculous meningitis in children aged 0–14 years in 2019: a mathematical modelling study Tuberculous meningitis is fatal if untreated and can lead to lifelong neurological sequelae. However, to our knowledge, there are no data on the numbe…

Happy to have been part of the mammoth team effort reviewing and modelling the burden of TBM in children #TBsky www.sciencedirect.com/science/arti...