We had a great time at #BMES2025. This was the first conference my lab attended together and I couldn't be more thrilled with their performance and the exciting work that we saw presented!

This is figure 1, which shows the variant call sets.

A paper in Nature reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation. go.nature.com/415CMhr 🧬 🧪

BioMed X Institute BioMed X Application System

Only two weeks left to apply for #ResearchFunding and join us in Ridgefield, Connecticut. Establish your own group and receive 890k USD/year for up to 5 years, access cutting-edge infrastructure!

career.bmedx.com/call/2025-RD...

#ScienceWithImpact #Ophthalmology #TissueEngineering #Biotherapeutics

The U.S. Senate is currently considering a budget reconciliation bill that quietly includes language that could devastate our public lands. It would:
- Make over 250 million acres of public land eligible for sale
- Mandate the sale of at least 2 million acres of Forest Service and BLM land

BioMed X Institute BioMed X Application System

My institute posted a request for proposals to lead a group focused on occular research. It's a good opportunity for someone ready to transition to independence or someone looking for a postdoc with private funding. Added bonus: ou get to be my neighbor!

career.bio.mx/call/2025-RD...

Tenure-track Faculty position just opened up in my department! If you want to be part of a dynamic group who is excited about science, apply. For more details, visit www.usherbrooke.ca/emplois/offr...

Please share in your networks! #microsky

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression - Nature Communications In this study by Meizoso-Huesca et al. regional skeletal muscle differences in ryanodine receptor Ca2+ leak were found. Without dysferlin, this raised leak is not tolerated long-term and leads to limb...

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression
www.nature.com/articles/s41...

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

@gabriellekardon.bsky.social is a fantastic scientist working on exciting projects. If you want to work on molecular biology in skeletal muscle, this could be your lucky day!

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

A heart muscle cell (cardiac myocyte) photographed through a microscope. Actin filaments are shown. #CellBiology

My lab is hiring a research assistant. If you love culturing cells but wish they weren't so flat, come bioprint with us: we culture in spheres! We culture in cubes! We culture in bioprinted vessels!
www.linkedin.com/jobs/view/41...

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...

Skeletal muscle fibers have many nuclei and the nuclei are different from each other despite being inside the same cell. This excellent paper looks at specialized transcript profiles of the nuclei that maintain the neuromuscular junction. It's open access!

www.nature.com/articles/s41...

The long running effort to de-extinct wooly mammoths has given us the gift of wooly mice! By modifying 10 genes to match mammoth variants they made very cute very fluffy mice. Check out their preprint!

www.biorxiv.org/content/10.1...

Standing up for what is right comes with a personal cost, but gives us the world we want to live in. I am grateful for those who choose to do so across business, science, and government and hope that each of us can find the moral fiber to make similar choices when our time comes.

Thanks, John! My lab is building an in vitro artery to model inflammation. We can bioprint an artery with primary human cells and are excited to start seeing how it responds to inflammatory insult. Come perturb arteries with me in New Haven!

My lab is hiring! I have budget for a post-doc and a research assistant. We're bioprinting a 3D in vitro artery to model inflammation. If you wish you were bioprinting arteries with me in New Haven, CT, reach out! I'd be particularly excited if you have immunology experience!

Engineered heart muscle allografts for heart repair in primates and humans - Nature Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading to improved cardiac function and paving the way for human clinical trials.

A muscle patch developed using stem cells can help to repair failing hearts without adverse effects, according to a paper in Nature. #Medsky 🧪

Stop the halt of NIH!
I am reaching out to ask that you call your US Senators/Reps. Especially those of you in red states! Tell them how important the NIH is!

House of representatives switchboard: 202-224-3121

T. Rex Evolution xkcd.com/3042

The White House honored five exceptional NM educators with the Presidential Award for Excellence in Math & Science Teaching. Congrats to Tara Palomares, Kimberly Conell, Heather Harrell, and Golden Apple Fellows Chris Speck (2018), and Lesha Rupert (2020)! 🎉

Sex-biased human thymic architecture guides T cell development through spatially defined niches Stankiewicz et al. generate a spatial multiomic resource of human postnatal thymus. Using a niche-centric approach, they show that sex-based differences in thymus biology and T cell development arise ...

This paper came out of the Rossi lab. You will probably like it if you like: 1) fibroblast subtypes 2) T cell maturation 3) all the sequencing (CITE, ATAC, spatial) and 4) understudied sexually dimorphic traits.
www.cell.com/developmenta...

BioMed X Institute BioMed X Application System

My institute has an open call for applications for a new oncology related project. I started my research group off a similar call and it has been a very exciting year and a half starting up the research!
Take a look!
career.bio.mx/call/2025-BM...

Myofibers cultured in viscoelastic hydrogels reveal the effects of integrin-binding and mechanosensing on muscle satellite cells Quiescent skeletal muscle satellite cells (SCs) located on myofibers activate in response to muscle injury to regenerate muscle; however, identifying …

This story grew out of a surprising result to a different experiment. Excellent work, Amie Chang!
www.sciencedirect.com/science/arti...