Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Understanding why cancers relapse - sometimes years or decades after successful treatment - is a major challenge in the cancer field

This perspective in Nature discusses several of the important recent advances and new studies in the field of tumor dormancy 🧪⚕️

www.nature.com/articles/d41...

90% of doing science is being open to new ideas.

High-resolution climate model forecasts a wet, turbulent future With details as fine as short-term weather forecasts, model achieves newfound accuracy

My latest for @science.org: A remarkable set of high-resolution climate model runs, computed over 900 (!) days of supercomputing time, are revealing how warming-induced changes to Earth's wind patterns due can prime huge spikes in extreme rainfall.

But the MESACLIP runs also do much more than that.

Brain tumor classification from FFPE samples using nanopore methylation sequencing Abstract. Oxford Nanopore Technology (ONT)-based methylation sequencing is emerging as a powerful approach for the rapid and accurate classification of bra

As a scientist, there are not many things more gratifying than to see my teams’ work directly involved in saving lives and @nanoporetech.com applied routinely in the clinic.
Big thanks to all the great team from Schneider Children’s Medical Center.

academic.oup.com/narcancer/ar...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

🧵1/17

📣Thrilled to share our latest study just out in Cancer Discovery!

➡️
aacrjournals.org/cancerdiscov...

Good ideas come from having lots of experience. And experience comes from having lots of bad ideas.

🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽

📖 Read our paper here: doi.org/10.1126/sci...

🎬 Watch a summary: youtu.be/MttCA3GGWEM

🧵 Or keep reading for the key points! 🔑 1/19

En el camino de Antonio Machado.

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

A cartoon titled ‘The Life of a Scientist’. (The life is depicted as a set of steps, three up then three down with a character on each) Baby: Such a mysterious world! Child: I must search for answers Young adult: Each answer leads me to more questions Middle age: ... At least I've got lots of questions Old age: Ok, I guess questions are my thing now From grave: Such a mysterious world!

My latest @newscientist.com cartoon

Academia isn’t perfect, but it offers a rare space to pursue knowledge for its own sake. If research were fully privatized, only profit-driven questions would get asked. Yet many of the most transformative discoveries began as curiosity-driven inquiries whose value wasn’t clear for years.

Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.

In #ScienceAdvances, a special issue on #WomensHealth highlights a growing wave of research focusing on women’s unique biological and psychological experiences.

Learn more on #WorldHealthDay: scim.ag/3R59fPe

Immunogenomic cancer evolution: A framework to understand cancer immunosuppression Understanding the impacts of genetic abnormalities on immune responses to tumors can inform immunogenomic-based precision medicine.

A new #ScienceImmunology Review suggests that genomic changes in cancer cells can shape antitumor immune cells and facilitate immunogenomic cancer evolution, which could inform future strategies for precision medicine. scim.ag/3FS4PZP

The end of the genetic paradigm of cancer Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

Provocative but important commentary from Sui Huang & co

Argues we need to change the paradigm of cancer origin from a somatic mutation theory to one grounded in gene regulatory networks & tissue organisation: a system level rather purely genetic mechanism

journals.plos.org/plosbiology/...

"Cancer affects everyone, but the burden of cancer isn’t distributed evenly across the popn[...]
income and education, play a particularly large role in driving cancer inequalities.
New report illustrates the scale of the problem" 👇
@cruk-mi.bsky.social @mcrcnews.bsky.social @holmepaul.bsky.social

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

Today our study using copy number alterations (CNAs) from low-coverage WGS to predict FUTURE colorectal cancer in patients with IBD is published, details in thread! 1/5
gut.bmj.com/content/earl...

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out: gut.bmj.com/content/earl...

The initial reaction from patients&families has been overwhelming

Led by Ibrahim AlBakir @yosoykit.bsky.social @cancerresearchuk.org @icrlondon.bsky.social

Researchers uncover what drives aggressive bone cancer Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.

Osteosarcoma, an aggressive bone cancer, most commonly affects children and young adults.

New research solves the mystery of what drives the genomic rearrangements causing the aggressive development and evolution of osteosarcoma tumours.

www.ebi.ac.uk/about/news/r...
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Inherited genome instability Germline structural variants are a risk factor for pediatric extracranial solid tumors

Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers

The concept of peer review is correct, but the execution is flawed and creating a broken system: Not enough well compensated editors, each under-experienced and overloaded. They lack the time and training to decide which papers to send out to review and which wasteful reviewer requests to overide

Keeping Research Curious: The Fuel for Breakthroughs in Cancer Research - The Cancer Researcher EACR member Mounia Benbelkacem writes about curiosity's role in cancer research.

"Embracing curiosity means remaining open to new ideas and approaches, no matter how unconventional they may seem" #KeepResearchCurious ✨

EACR member Mounia Benbelkacem writes about the value of maintaining curiosity in your cancer research journey:

magazine.eacr.org/keeping-rese...

Can processes occurring in one individuals nervous system influence the physiology of the descendants?
Cool work 👇🏼

Genetic immune escape in cancer: timing and implications for treatment Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which …

Excited to share our perspective on genetic immune escape alterations and their impact on tumor evolution, metastasis, immunotherapy, and interactions with tumor-extrinsic factors. It was a pleasure collaborating with Diego on this -hope you enjoy the read!☺️

www.sciencedirect.com/science/arti...

Could you add me here, please? 😊

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells - Nature Reviews Cancer In this Review, Rabas et al. describe the mechanisms by which primary tumours precondition distal organs to favour metastatic colonization — a limiting step of metastasis — and dis...

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells

www.nature.com/articles/s41...

This is a great post from @gangfang.bsky.social on the use of Oxford Nanopore (or PacBio) technologies for DNA modification detection.
The conclusions are that Oxford Nanopore works well for 5mC in most mammalian tissues where it is expected to be the majority modification in CpG context, but

Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors Human tumors are intricate ecosystems composed of diverse genetic clones and malignant cell states that evolve in a complex tumor micro-environment. S…

Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors.
Itay Tirosh & Mario L. Suva
www.sciencedirect.com/science/arti...

Resolution of ring chromosomes, Robertsonian translocations, and complex structural variants from long-read sequencing and telomere-to-telomere assembly Genomic rearrangements in repetitive regions have long eluded sequence-based characterization by standard genomic methods. We leveraged long-read sequencing to resolve the architecture of ring chromos...

Resolution of ring chromosomes, Robertsonian translocations, and complex structural variants from long-read sequencing and telomere-to-telomere assembly. #LongReadSequencing #Genomics #StructuralVariants 🧬 🖥️
www.cell.com/ajhg/abstrac...