Sovereign AI officially launched yesterday to put Britain at the forefront of #AI. Supporting #OpenBind in its foundation phase, the £8 million seed fund will enable datasets for protein-drug complexes at an industrial scale, specifically for #AI to speed up #DrugDiscovery. https://loom.ly/eHc59cA
Curious about #AI driven protein-ligand modelling and the role of #OpenBind?
If you’re at #DrugDiscoveryChemistry next week, come along to this session in the Generative AI & Predictive Modelling track to find out more.
https://loom.ly/6kqUfSE
cicbiogune.bsky.social & partners used #cryoEM at diamondlightsource.bsky.social to see how the #antibiotic GE81112 binds bacterial ribosomes - revealing a new target that could lead to treatments for drug‑resistant infections. https://loom.ly/TLDCaBs
bostonscientific.bsky.social, qubelfastofficial.bsky.social & uniofgalway.bsky.social used WAXS at diamondlightsource.bsky.social to reveal #PLLA #stent microstructure, linking crystalline form to thermal & mechanical stability - key to long‑term safety & performance. https://loom.ly/vv8NPbo
MSI‑H/MMRd #cancers can depend on #WRN helicase. Merck & Co. Inc., and Proteros Biostructures used #fragment‑based discovery at @diamondlightsource.bsky.social to find real WRN binders & map how they bind. https://loom.ly/iMwR8oM
Good to see #OpenBind referenced in the UK’s AI for Science Strategy, highlighting the importance of open, #AI‑ready data in accelerating drug discovery. https://loom.ly/Rxt5JL8
Using #cryoEM at Diamond’s #eBIC, researchers at wellcometrust.bsky.social found that a single mutation lets #HIV rebuild its capsid and stay infectious without the host molecule IP6. The study reveals a previously unknown structural role in the HIV capsid. https://loom.ly/5WlkvVE
Insilico Medicine used #MX at Diamond and AI to create D16‑M1P2, a PROTAC targeting PKMYT1 that blocks & destroys the protein, works orally, is highly selective (CCNE1 amplification; FBXW7/PPP2R1A), and reduces resistance and side effects. Find out more: https://loom.ly/ZRdVjPA
At Diamond’s #XChem facility, Syngenta & Centre for Medicines Discovery solved Arabidopsis FatA at 1.5 Å & found 129 fragment hits across key sites - unlocking structure-guided FAT inhibitor design for safer, smarter crop protection. https://loom.ly/mUHm-_A
#HerbicideResistance #Agrochemicals
Exciting news for #OpenBind! Ali Ebrahim will be working with the #XChem team at Diamond to help analyse and curate structural data for our data‑release packages and software, boosting the quality and utility of ML training sets. Welcome aboard, Ali!
Why do endotoxin tests fail? @astra-zeneca.bsky.social & @manchester.ac.uk used DLS and #SAXS at Diamond to uncover why Low Endotoxin Recovery happens - challenging old assumptions. Read more: https://loom.ly/AKGcYXA
At #CCP4 Study Weekend, Jasmin Aschenbrenner showcased #OpenBind - an initiative creating high-quality #FragmentScreening data at Diamond to power next-gen machine learning for #DrugDiscovery.
Learn more about this initiative:
Website: http://www.openbind.org
Bluesky: @openbind.bsky.social
Attending #CCP4? Don’t miss Day 2 at 16:00–16:30! Discover how Diamond’s #FragmentScreening facility accelerates early-stage drug discovery. Hear Ailsa Powell share how XChem speeds structural insights from concept to candidate. https://loom.ly/mZKk5ys
Season’s Greetings from the Industrial Liaison Team at Diamond! Wishing all our colleagues, partners, and clients a joyful festive season and a successful year ahead. Thank you for your continued collaboration – we look forward to achieving great things together in 2026!
Welcoming our two new team members with a photo shoot to showcase their work. Ole and Shashank will be joining our #MX/#Xchem and #eBIC4i teams to support services for #industry. Great to see them already making an impact! https://loom.ly/gSCzEzc
