Inhibition of autophagic flux boosts the interaction of NBR1 and Tau and increases aggregated Tau levels, while the knockdown of NBR1 specifically increases neuronal Tau aggregation.

The #autopahgy receptor NBR1 interacts with aggregated and phosphorylated #Tau in various cell systems and human #Alzheimer's disease brain

We find novel phosphorylation sites on NBR1 that are triggered by seed-induced Tau aggregation.

A role for the autophagy receptor NBR1 in the degradation of tau aggregates Neurofibrillary tangles (NFTs), comprising hyperphosphorylated and aggregated Tau protein, are a primary neuropathological feature of Alzheimer's Dise…

Happy to share our latest, by my PhD student Marie... sad because it was her last day today, happy because it coincided with her paper being out! www.sciencedirect.com/science/arti...

Happy Canada day to all Canadian friends! 🥳🇨🇦

Bist a Mädl, ein TU Studium ist nix für dich...

Wäre toll, wenn das noch ein paar Leute teilen könnten.

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org/news/2025/ke...

Happy for you guys! Been thinking about my Canadian friends a lot these days...

Links Melania Trump mit einem blauen Hut mit breiter Krempe, rechts Trump beim Versuch seine Frau auf die Wange zu küssen.

Form follows function.

❗Kickl wird Österreich mit 2 Milliarden #Klimasteuer belasten❗

Diesen Satz sollte jeder FPÖ Wähler oft genug hören. (ÖVP-Wähler analog)

Exil Kärntnerin musste kichern...

Ziemlich unübersehbare Menschenmassen am Ballhausplatz gegen einen Rechtsextremisten als Kanzler

Great collaboration with the Nussbaum lab, formerly Uni Heidelberg, now @ LMU Munich. How does #Tau protein spread, and most importantly, how does it not get digested after #endocytosis? Learning about mechanisms that may be important for #Alzheimer disease.

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation https://www.biorxiv.org/content/10.1101/2024.11.13.619586v1 The spreading of Tau pathology is closely associated with the progression of neurodegeneration and c

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation www.biorxiv.org/content/10.1101/2024.11....

Wow, congratulations! 🎉

Yes, thanks!

Hi Dale, the link seems broken... 😕

Good plan! Hope you can enjoy the summer a bit afterwards!

You got this! 🤞🤞

Merry Christmas to the handsome couple! And a happy and successful 2024!

Yay, congratulations 🎉!

Thanks!

ChatGPT Replicates Gender Bias in Recommendation Letters A new study has found that the use of AI tools such as ChatGPT in the workplace entrenches biased language based on gender

Many recommendation letters written by humans are subtly sexist. Letters written by AIs amplify and expose that sexism. In a new study, male candidates' words include "thinkers" "expert" "integrity" & female candidates' are "emotional" "grace" "delight" 🧪 www.scientificamerican.com/article/chat...

Yes!

Hi Dani, would love to be added, thanks! scholar.google.com/citations?us...

What does the fox (genome) say? A chromosome-level assembly for the gray fox (Urocyon cinereoargente... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Instant legendary status for this paper title www.biorxiv.org/content/10.1...

The Woman Who Demonstrated the Greenhouse Effect Eunice Newton Foote showed that carbon dioxide traps the heat of the sun in 1856, beating the so-called father of the greenhouse effect by at least three years. Why was she forgotten?

The Woman Who Demonstrated the Greenhouse Effect: Eunice Newton Foote showed that carbon dioxide traps the heat of the sun in 1856, beating the so-called father of the greenhouse effect by at least three years. www.scientificamerican.com/article/the-...