New Preprint alert! Excited to share our latest work on the #MAPKinases from stellar PhD student Jill von Velsen. First structures of the MAP2K MEK1 activating its substrate MAPK between 2.9 and 3.6A - amazing resolutions for such a small and mobile complex! www.biorxiv.org/content/10.6...
A huge thank you to @inserm.fr 😄 for the visit, for the interest in our vibrant #Grenoble ecosystem, and for shining a light on our research in this short film 🎬
www.youtube.com/watch?v=dkej...
Retrouvez dès maintenant le teaser : www.youtube.com/watch?v=7P9L...
Image décorative.
La cérémonie des Prix Inserm 2025 a récompensé 5 lauréates et lauréats !
👏👏👏 Bravo @hakimi.bsky.social on winning the 2025 @inserm.fr Research Prize and the @fondationdefrance.bsky.social Allianz Prize!
Hakimi's team is cracking #Toxoplasma's secrets, and developing innovative therapies to block transmission.
@academiesciences.bsky.social
©Inserm/François Guénet
Huge congratulations to @hakimi.bsky.social for receiving the 2025 INSERM Research Award! 🎉
We’re extremely proud to have him as part of LabEx ParaFrap.
👉 : presse.inserm.fr/prix-inserm-...
What an exceptional week! At the Collège de France, surrounded by my family 🥰 and part of my Dream Team, I was honored with the 2025 Inserm Research Prize! Truly proud. 🙏 INSERM This award goes to an outstanding team and to my loved ones who have carried me through this scientific journey.
What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥
@ugrenoblealpes.bsky.social
@inserm.fr
@cnrs.fr
By any means necessary
James Watson’s passing marks the loss of a major figure whose work profoundly shaped modern biology. He is also a man whose racist and misogynistic remarks can’t be separated from his legacy. Science isn’t just about discovery; it’s about upholding universal human dignity. Rest in peace.
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto
www.nature.com/articles/s41...
A fantastic week in Grenoble hosting my friend Amit Sharma for our @inserm.fr IRP project. With Christopher Swale on board, they pulled off a cryo-EM structure in just a few days! A great reminder that science thrives on teamwork — and friendship. Grateful to @inserm.fr for the support!
Christopher Swale just nailed his HDR — the top academic milestone in France 🎓He can now supervise PhD students on his own. Stellar talk, razor-sharp answers, the jury was impressed. Proud of you, Chris. 👏
Winter’s first snow over Grenoble, straight from the office view.
Four years, one PhD, many smiles… and a standout CV. Bravo Dr. @belenpachano.bsky.social Enjoy Munich with @siegel-lab.bsky.social and his dream team!
On Friday, I had the privilege of speaking with a remarkable line-up of Artur Scherf alumni at a symposium devoted to his stellar contributions to parasitology in general and malaria specifically. It was wonderful to pay tribute to a friend and visionary whose legacy continues to inspire.
So proud of my PhD student Martina Shahinas 🌟 She gave a stellar talk and shared her latest results—still chasing the sexual stages of Toxoplasma. embo.org Conference / parafrap.bsky.social was a success with an amazing speaker lineup on the ☀️Île des Embiez, Côte d’Azur.
Oh how fantastic evolution is… every day it drops a new plot twist. 🤯🧬 Nature, who coded you?! 🤩
t.co/yXmctCX6PA
Congrats Dr. Silvia DIAZ MARTIN on a brilliant PhD defense. 🙏to jury Maryse, Thierry, Matthew, Ludovic & Diego for their sharp eval. Shout-out to Alexandre and Christopher for their steady mentorship. You made us proud Silvia and I saw the whole galaxy of family pride reflected in your dad’s eyes.
🙏 @inserm.fr de promouvoir nos travaux récemment publiés dans EMBO Mol. Med
doi.org/10.1038/s443...
www.inserm.fr/actualite/to...
I should start by correcting that it was Heracles—not Zeus—who fought the Hydra 😉
Zeus had his Hydra ⚔️, now Toxoplasma has its own.
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
Pas mieux cher ami 😉
Thrilled to share our latest review! 🎉 It captures the ideas and discussions that have shaped our work in recent years. Big shoutout to the amazing authors 👏 @hakimi.bsky.social
www.sciencedirect.com/science/arti...
Toxoplasma facing career options:
🏃 Tachyzoite (fast life)
😴 Bradyzoite (chronic sleeper)
🙀 Pre-sexual (cat-ready)
Spoiler: epigenetics makes the call.
Our recent review in Current Opinion in Microbiology decodes how chromatin remodelers, TFs& AP2s orchestrate these fates 👇🏽
doi.org/10.1016/j.mi...
Bravo @meryemaloulou.bsky.social , @nfazilleau.bsky.social et al. 🥳
Our July issue is online 👉 www.embopress.org/toc/17574684...
The cover highlights the article by M Robert, C Swale, MP Brenier-Pinchart, @hakimi.bsky.social & al. that identifies BSM & BCLA as #biomarkers for chronic #ToxoplasmaGondii infection
Scientific image by @hakimi.bsky.social @inserm.fr
Thrilled to see our work featured on the cover of @embomolmed.org 🎉We identify new biomarkers to track chronic toxoplasmosis—paving the way for improved diagnosis and patient care.
doi.org/10.1038/s443...
It’s time to bring such tools to the clinic—let’s encourage biotech to take it from here.
Huge congrats @belenpachano.bsky.social on your PhD! Honored to have shared the journey. Your brilliance shines through your articles — past and future. You’ll be missed, but my lab will always be your home. Come back anytime. You’ve earned every success!
I hear you, brother. Loud and clear. Your courage speaks volumes. Standing strong with you—and with Palestine. You're not alone.