Next week!!

The JACS Symposium: CSJ Spring Meeting is an inspiring full-day, in-person symposium spotlighting cutting-edge research in organic, inorganic, polymer, and materials chemistry.

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Join leading chemists, a Nobel Laureate, researchers, and journal editors in Jeju Island, Republic of Korea, as we celebrate 150 years of ACS, chemical discovery, and explore the future of scientific collaboration

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Congratulations to #OrgLett Executive Editor Margaret Brimble on being named Honorary Fellow of the RSC! We are honored to have you and several other 2026 Honorary Fellows on our teams at ACS

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Hard-Won Lessons from Industrial Chemistry Failures | ACS Publications Chemistry Blog A collection of candid case studies reveals how industrial chemists diagnose failures and redesign processes with clarity and purpose.

ACS Industry Insider and OPR&D have teamed up to bring some Lessons Learned in Organic Process Chemistry to the forefront of discussion. Our webinar with Yuhei Yamamoto showcased how even elevation of a CDMO can affect route optimization!

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Truly never out of style! #JOrgChem celebrates the latest physical organic chemistry research with nearly 100 articles in this Special Issue. From quantum tunneling to catalyst design revealing how structure, energy, and environment drive reactivity!

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Call For Papers: Communications & Technical Notes in OPR&D | ACS Publications Chemistry Blog Have a short story to share, or a new protocol that doesn’t fit into a standard full Article? OPR&D is putting out this open Call for Short Papers, welcoming submissions as Communications or Technical...

🚨 Call for Short Papers – Communications & Technical Notes

Have a breakthrough that doesn’t fit a full-length article? #OPRD is now accepting Communications and Technical Notes—short, focused papers designed to move ideas forward faster.

👉 axial.acs.org/organic-chem...

Highlighting Chinese Chemists in Organic Letters: Chinese New Year Cover Series, 2025 China Collection, and All-Star Academy Webinar | ACS Publications Chemistry Blog Join ACS Publications in celebrating China’s leading researchers, cultural heritage, and impactful work published in the journal.

Submit your Lunar New Year themed covers celebrating the Year of the Horse! 🎆 Submissions in process until February 10 will be considered. Only a few will publish on the front cover an an issue of #OrgLett!

Check out last year's covers featured here ➡️ axial.acs.org/organic-chem...

This special collection showcases impactful work supported by the ACS Petroleum Research Fund (PRF) over the past 25 years, highlighting advances in catalysis, energy, and sustainability that span inorganic, organic, and organometallic chemistry.

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Sign up for our ACS Publications Industry Webinar where we will have #OPRD author Yuhei Yamamoto describe a real-world case study on scale-up of Suzuki-Miyaura couplings.

December 11, 2025 at 9 AM Japan Standard Time (December 10, 2025 at 7 PM ET / 4 PM PT)

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Safety First in Organic Chemistry! ⚠️

#OrgLett published its first "Safety Letter" by Garg, Zhao, and co-workers, spotlighting IBX—a widely used oxidant with explosive potential.

Read the Safety Letter and Editorial in this week's issue:
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Organic and Inorganic Chemistry Lectureships and Awards | ACS Publications Chemistry Blog Explore both current and past journal lectureships and awards from ACS Publications' Organic and Inorganic portfolio.

Submit your nominations today for the Organic and Inorganic Lectureship Awards! Winners will receive an honorarium, plaque, and travel to ACS Fall 2026 in Chicago, IL, to present their outstanding work.

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Call For Papers: Chemistry and Biology of Peptides | ACS Publications Chemistry Blog This Special Issue will celebrate the chemistry and biology of peptides, from synthesis, to structure and modifications, to biology and applications, and finally to degradation. Submit your manuscript...

Time is running out! ⏲️ Submit your manuscript by Dec 31 to #JOrgChem or #Biochemistry for this joint Special Issue featuring the chemistry and biology of peptides.

Learn more and submit here 👉 axial.acs.org/biology-and-...

Structural and Functional Dissection of GH161 β-Glucan Phosphorylases: Molecular Specificities and Dynamics of Catalysis of Dimeric GH-Q Enzymes In the CAZy classification of carbohydrate-active enzymes, the GH-Q clan regroups three distantly related glycoside hydrolase (GH) families: GH94, GH149, and GH161. These families contain glycoside ph...

Unlocking the secrets of GH161 enzymes! 🧬 Using cryo-EM, Moulis, Cioci, & co-workers reveal how β-glucan phosphorylases reshape during catalysis—shedding light on the molecular choreography of GH-Q clan enzymes #Biocatalysis #ACSCatalysis @cathleencrudden.bsky.social

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The ACS GCI PR Industry Awards spotlight the best in sustainable/green chemistry innovation across the pharma industry and allied industrial partners.

Submit your nomination by Dec. 8! ➡️ acsgcipr.org/funding-awar...

Copper–Iron-Catalyzed Cross-Coupling of ortho-Substituted Sulfonamides with Sterically Hindered (Hetero)aryl Chlorides and Alkyl Halides: Synthesis of Sulfonamide Drugs We describe for the first time an effective copper–iron-catalyzed cross-coupling strategy that enables the reaction for a diverse array of ortho-substituted primary (hetero)aryl and aliphatic sulfonam...

Copper–Iron catalysis unlocks efficient cross-coupling of sterically hindered sulfonamides with (hetero)aryl chlorides & alkyl halides in #OrgLett #EditorsChoice

✅ Diverse substrate scope
✅ Gram-scale
✅ 10 sulfonamide drugs synthesized

Read more 👉 pubs.acs.org/doi/10.1021/...

🚨 Call for Papers!

Ready to reshape the future of organic synthesis? Submit to our Special Issue: “Skeletal Editing, Molecular Metamorphosis & Structural Reprogramming” jointly hosted by #OrgLett & #JOrgChem

📅 Deadline: June 1, 2026

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@cathleencrudden.bsky.social

Temporal Resolution of In Situ TEM Limits the Characterization of Catalyst Site Dynamics In situ transmission electron microscopy (TEM) provides a means for capturing atomic-resolution micrographs under reactive environments and has been widely employed to identify active site candidates ...

In situ TEM doesn't get the full picture. Atomic-resolution imaging is powerful, but sub-nanosecond catalyst dynamics remains difficult. This #EditorsChoice #ACSCatalysis Viewpoint shows why we need more than TEM by Tibor Szilvási

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Sponsored by: @organicdivision.org & @pubs.acs.org

Nominate work for the #JOrgChem 2026 Outstanding Paper of the Year Award by Dec 31!

The award winner will receive:
- $2000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

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Sign up for our ACS Publications Industry Webinar where we will have Amanda Stahl (Amgen) describe the fascinating process development of a key Sotorasib intermediate.

Nov 11, 2025 at 12:00 noon (EST)

access.acspubs.org/Rac4Process

@cathleencrudden.bsky.social

Asymmetric Diamination of the In Situ Generated Difluoroenol Species Using Azocarboxamides as an N Source The Rh2(esp)2 and Zn(II)-bisoxazoline (BOX) complex-cocatalyzed asymmetric diamination of in situ generated difluoroenol species with azocarboxamides has been disclosed. This reaction features a formal [3 + 2]-cycloaddition reaction using difluoroenol intermediate as a C2 synthon, providing an efficient and robust approach for the synthesis of difluorinated imidazolidin-2-ones in good yields with high to excellent stereoselectivity (up to 95% ee). This method offers a complementary approach for the direct assembly of chiral difluoromethylene incorporated heterocycles by introducing in situ formed difluoroenol species as a practical C2 synthon rather than using presynthesized gem-difluoroalkenes. With this protocol, further synthetic applications in fluorine chemistry could be envisioned through the strategic interception of difluoroenol via cycloaddition reactions with appropriate partners.

Check out this CF2 synthon enabled by dual Rh-Zn catalysis in #ACSCatalysis #EditorsChoice

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@cathleencrudden.bsky.social

Sponsored by: @organicdivision.org , @pubs.acs.org

Submit your nominations for the ACS Catalysis Lectureship Award by Dec 31!

The award winner will receive:
- $1000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

Sponsored by: @organicdivision.org & @pubs.acs.org

Nominate Articles for the #OPRD 2026 Outstanding Paper of the Year Award by Dec 31!

The award winner will receive:
- $2000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

Sponsored by: @organicdivision.org & @pubs.acs.org