#OrgLett FTW!

Seven world-class scientists awarded Honorary Fellowships The Royal Society of Chemistry is proud to announce that seven of the world's most influential scientists have been awarded Honorary Fellowships.

Congratulations to #OrgLett Executive Editor Margaret Brimble on being named Honorary Fellow of the RSC! We are honored to have you and several other 2026 Honorary Fellows on our teams at ACS

www.rsc.org/news/2026-ho...

HFIP-Mediated (3+2) Annulation of Bicyclobutanes with Indolyl Alcohols for Diastereoselective Access to Tetracyclic Spiroindolenines Although bicyclo[2.1.1]hexanes (BCHs) have emerged as powerful bioisosteres of substituted benzenes, efficient methods for the synthesis of their spirocyclic variants remain limited. Herein, we disclo...

Just out #OrgLett, our work on HFIP-mediated (3+2) annulation of BCBs with N-H indolyl alcohols for the diastereoselective synthesis of spiroindolenines😃!

Cool work by Shiksha 👏👏!

We thank SERB for financial support🙏!

iiscbangalore

Highlighting Chinese Chemists in Organic Letters: Chinese New Year Cover Series, 2025 China Collection, and All-Star Academy Webinar | ACS Publications Chemistry Blog Join ACS Publications in celebrating China’s leading researchers, cultural heritage, and impactful work published in the journal.

Submit your Lunar New Year themed covers celebrating the Year of the Horse! 🎆 Submissions in process until February 10 will be considered. Only a few will publish on the front cover an an issue of #OrgLett!

Check out last year's covers featured here ➡️ axial.acs.org/organic-chem...

Microwave-Assisted Synthesis of Heterocycles via Rhodium(III)-Catalyzed C–H Activation: Norbornadiene as an Acetylene Equivalent General procedures for the rhodium-catalyzed annulation of aryl/heteroaryl O-pivaloyl hydroxamic acids and norbornadiene have been developed. Employing norbornadiene as an acetylene equivalent enables...

My favorite 2025 #PfizerChemistry publications #12daysOfPapers 1/n: From my La Jolla colleagues this is a cool use of Rh-catalyzed C-H activation followed by retro Diels-Alder to provide useful med chem heterocycles #OrgLett
#ChemSky #ChemChat

Safety First in Organic Chemistry! ⚠️

#OrgLett published its first "Safety Letter" by Garg, Zhao, and co-workers, spotlighting IBX—a widely used oxidant with explosive potential.

Read the Safety Letter and Editorial in this week's issue:
pubs.acs.org/toc/orlef7/2...

Copper–Iron-Catalyzed Cross-Coupling of ortho-Substituted Sulfonamides with Sterically Hindered (Hetero)aryl Chlorides and Alkyl Halides: Synthesis of Sulfonamide Drugs We describe for the first time an effective copper–iron-catalyzed cross-coupling strategy that enables the reaction for a diverse array of ortho-substituted primary (hetero)aryl and aliphatic sulfonam...

Copper–Iron catalysis unlocks efficient cross-coupling of sterically hindered sulfonamides with (hetero)aryl chlorides & alkyl halides in #OrgLett #EditorsChoice

✅ Diverse substrate scope
✅ Gram-scale
✅ 10 sulfonamide drugs synthesized

Read more 👉 pubs.acs.org/doi/10.1021/...

🚨 Call for Papers!

Ready to reshape the future of organic synthesis? Submit to our Special Issue: “Skeletal Editing, Molecular Metamorphosis & Structural Reprogramming” jointly hosted by #OrgLett & #JOrgChem

📅 Deadline: June 1, 2026

axial.acs.org/organic-chem...

Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks Herein, we report a practical and efficient carbon-to-nitrogen atom swap in 2-phenylimidazo[2,1-a]isoquinoline and 2-phenylimidazo[1,2-a]quinoline scaffolds, enabling their direct conversion to the corresponding 2-phenyl-[1,2,4]triazolo[5,1-a]isoquinoline and 2-phenyl-[1,2,4]triazolo[1,5-a]quinoline analogues. This transformation exploits the intrinsic reactivity of the parent heterocycles to undergo a cascade sequence involving oxidative cleavage, amination, and cyclization (OCAC) under mild conditions with functional group tolerance.

Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks | Organic Letters #SkeletalEditing #Atomswap #OrgLett #Hypervalentiodine @acs.org @pubs.acs.org pubs.acs.org/doi/full/10....

Nominate Letters for the #OrgLett 2026 Outstanding Paper of the Year Award by Dec 31!

The award winner will receive:
- $2000 USD prize
- Complimentary travel and registration to ACS Fall 2026 in Chicago to deliver the award lecture
- Award plaque

americanchemical.co1.qualtrics.com/jfe/form/SV_...

🚨Special Issue Alert🚨

π-Conjugated Molecules & Materials in #OrgLett

Honoring August Kekulé and Eric Clar, this Special Issue showcases everything from CPL and optoelectronics, to nonbenzenoid aromatic compounds and nanohoops.

pubs.acs.org/page/orlef7/...

A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides Advancements in the field of C(sp2)–C(sp3) cross-coupling using alcohols as feedstocks have resulted in widespread adoption in analogue synthesis. Using high-throughput experimentation, an in situ alc...

Editors' Choice alert! Plunkett, et al. in #OrgLett: A Simplified, One-Pot, Procedure for the Deoxygenative Alkylation of Aryl Bromides

pubs.acs.org/doi/10.1021/...

Congrats and thanks to Neil Garg, Ralph Zhao, and co-workers for publishing #OrgLett 's first Safety Letter: Evaluation of the Popular Oxidant 2-Iodobenzoic Acid (IBX)

pubs.acs.org/doi/10.1021/...

Emphasizing Safety in Publications at Organic Letters: The Safety Letter

Conducting impactful research for the betterment of the world and our society ought not to be overshadowed by the dangers and risks its practitioners take on. -- Read about our Safety Letter initiative at #OrgLett

pubs.acs.org/doi/10.1021/...

Iron-Catalyzed Decarboxylative Sulfinylation of Alkyl Carboxylic Acids Sulfinamides, sulfonamides, and sulfonimidamides are valuable motifs in medicinal chemistry, yet methods to synthesize alkyl variants from simple, readily available feedstocks remain scarce. In this report, we detail the synthesis of these three distinct sulfur functional groups, using readily available and structurally diverse alkyl carboxylic acids as the starting materials. The method harnesses alkyl radical generation from carboxylic acids using commercial iron salts and visible light irradiation, in combination with commercial sulfinylamine reagents, to deliver alkyl sulfinamide products. The method is operationally simple and scalable, exhibits broad functional group tolerance, and is translatable to continuous-flow synthesis. Furthermore, it facilitates late-stage diversification of complex molecules, highlighting its potential utility in medicinal chemistry applications.

#ChemSky As a medicinal chemist I often look at sulfonamides as isosteic replacements for R-CO2H and now thanks to the Willis lab @ Oxford @rhpdcu.bsky.social & Sygnature, you can do that synthetically too! One step sp3-CO2H -> sp3-SONH2 and acces to sulfonamides and sulfonimides #OrgLett asap

It's a privilege to have Marisa Kozlowski from
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett

N-Heterocyclic Carbene/Organic Photoredox-Cocatalyzed Acyl Azolation of Alkenes with Acyl Azoles We have developed the N-heterocyclic carbene/organic photoredox-cocatalyzed acyl azolation of styrenes using acyl azoles. The cooperative action of organic photoredox catalysis and NHC catalysis enabl...

Just published in #OrgLett ! We report an NHC/organic photoredox cocatalyzed acyl azolation of styrenes using acyl azoles. Congratulations Kanata and Yamato! doi.org/10.1021/acs....

Check out our latest initiatives to celebrate Chinese researchers publishing in #OrgLett! Learn about our Chinese New Year Covers Series, 2025 Collection of 36 Letters from China, ACS All-Star Academy, and more!

axial.acs.org/organic-chem...

A very big congrats to the #OrgLett winner of the Outstanding Publication of the Year Award, co-sponsored by the ACS Division of Organic Chemistry: Dr. Gabriel Schäfer and colleagues!

axial.acs.org/organic-chem...

Submit your abstracts for Pacifichem 2025! pacifichem.org

#OrgLett Executive Editor Margaret Brimble sends this call for abstracts for the Symposium on Peptide Therapeutics and Peptidomimetic. Margaret is one of the organizers along with Severin T. Schneebeli, Rotimi Aluko, and Hidehito Mukai

Recently, #OrgLett has published a series of Chinese New Year-themed covers to celebrate the Year of the Snake, a symbol of wisdom, transformation and renewal in Chinese culture--reflecting both cultural heritage and the vibrant synergy driving the frontiers in org chem of China

A Sterically Tuned 2-Fluoropyridinium Salt for the Catalyst-Free, Visible-Light-Mediated Deoxygenation of Alcohols via an Electron Donor–Acceptor Complex We here report the use of a sterically tuned 2-fluoro-1-methylpyridinium salt for the catalyst-free, visible-light-mediated deoxygenative transformation of alcohols through alkoxypyridinium intermedia...

#ChemSky cool new paper in #Orglett asap from Kyoto University using an activated pyridinium EDA complex to easily deoxygenate R-OH via radical process. Radical can be used for coupling as well. Seems a straightforward set up and useful

Read all about Gold-Mediated Chemistry in this #OrgLett Special Issue [ pubs.acs.org/page/orlef7/... ]

On the cover: Ancient Chinese alchemy believed that gold could be long-lasting and used to produce the elixir of life (长生不老药), by Zhonghua Xia [ pubs.acs.org/doi/10.1021/... ]

#Chemsky

Light-Driven Regioselective Deoxygenation of Carbohydrate Lactones for 2-Deoxy Sugar Precursor Synthesis A sustainable method for the synthesis of 2-deoxy lactones as direct precursors to 2-deoxy sugars via regioselective UV-light-driven dealkyloxylation of carbohydrate-derived lactones is detailed. This catalyst- and additive-free protocol utilizes light irradiation, providing high step economy and functional group compatibility. This environmentally friendly and straightforward approach enhances the synthetic toolbox for 2-deoxy sugars, which is vital in numerous biologically active molecules and drug candidates.

Light-Driven Regioselective Deoxygenation of Carbohydrate Lactones for 2-Deoxy Sugar Precursor Synthesis IOC_PAS Justyna Najczuk #OrgLett #OpenAccess

pubs.acs.org/doi/10.1021/...

This Lunar New Year #OrgLett cover [ pubs.acs.org/toc/orlef7/2... ] illustrates imagery of the snake, sleek, slithering, and symbolic of intuition, transformation, and growth in Chinese culture, bringing good fortune to the chemists [ pubs.acs.org/doi/10.1021/... ] #chemsky

This Lunar New Year #OrgLett cover [ pubs.acs.org/toc/orlef7/2... ] illustrates visible light-driven (fireworks) asymmetric photoredox catalytic Minisci reactions of azaarenes (boy's shirt) by electron-withdrawing carbonyl radicals (girl's shirt) [ pubs.acs.org/doi/10.1021/... ] #chemsky

Modular Construction of Chiral Aminopiperidine via Palladium-Catalyzed Hydroamination of 1,2-Dihydropyridine In this study, we describe a generally straightforward methodology for the catalytic synthesis of chiral aminopiperidine from pyridine and azoles. The key step was the palladium-catalyzed regioselecti...

Really liked this #OrgLett ASAP today from Wang et al (Xinjiang Technical Institute of Physics and Chemistry) making chiral piperidines via 4-selective animation of dihydropyridines - can definitely see some uses of this work in med chem
#ChemSky #PyridineAbuse

3-Alkyl-1,2,4-triazines as Heterocyclic Platforms for Organocatalytic Enantioselective Benzylic C–H Functionalization The α-3-(1,2,4-triazine)-α-cyanoacetate derivatives exhibit a unique and well-defined dearomatized structure undergoing efficient organocatalytic aromatization–alkylation sequences with Michael accept...

Thrilled to share how 1,2,4-triazines met asymmetric organocatalysis towards semisaturated heterocycles. Thanks to Anthony’s work (collab. Lab. CARMeN-ICOA, @JFBriere76 and F. Suzenet @Labex_SynOrg) in #OrgLett #chemsky

pubs.acs.org/doi/10.1021/...

Four advances for inactivating infectious viruses, bacteria - American Chemical Society As cold and flu season arrives, protecting oneself against viruses and pathogens becomes incredibly important. Read about how researchers publishing in ACS journals have found new antiviral compounds ...

An article recently published in #OrgLett was featured by the ACS pressroom! The study identified the structures of four metabolites that exhibited anti-RSV (respiratory syncytial virus) activity in cell culture experiments. #chemsky

www.acs.org/pressroom/pr...

Modular Assembly Drives Synthesis of High-Energy Linked/Fused Molecules In this study, we propose a “modular assembly” strategy to synthesize a series of new trinitromethyl high-energy molecules. For a typical molecule 1, this approach reduces the number of synthetic step...

Out Today! The newest #OrgLett soundtrack featuring hits like “Rearrange Me” and “Just Say NO” as well as the newest banger “We Don’t Talk About Nitro”