Happy to share a new way of promoting dual-atom insertion into oxetanes and azetidines to access multi-heteroatom rings using FLP chemistry, just out in @natsynth.nature.com nature.com/articles/s44... #skeletalediting #ringexpansion #FLP

Electrifying skeletal editing? Our latest work on a tunable electrochemical method that enables divergent N-heterocycle synthesis via N insertion into carbocycles.
#skeletalediting #expansion #electrochemistry #heterocycle

Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks Herein, we report a practical and efficient carbon-to-nitrogen atom swap in 2-phenylimidazo[2,1-a]isoquinoline and 2-phenylimidazo[1,2-a]quinoline scaffolds, enabling their direct conversion to the corresponding 2-phenyl-[1,2,4]triazolo[5,1-a]isoquinoline and 2-phenyl-[1,2,4]triazolo[1,5-a]quinoline analogues. This transformation exploits the intrinsic reactivity of the parent heterocycles to undergo a cascade sequence involving oxidative cleavage, amination, and cyclization (OCAC) under mild conditions with functional group tolerance.

Skeletal Editing Via CH→N Atom Swapping in Fused Imidazoles: Access to Triazolo[5,1-a]isoquinoline, Triazolo[1,5-a]quinoline, and Triazolo-[1,5-a]pyridines Frameworks | Organic Letters #SkeletalEditing #Atomswap #OrgLett #Hypervalentiodine @acs.org @pubs.acs.org pubs.acs.org/doi/full/10....

Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...

Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis

👉 buff.ly/XvYGfsW

Atom-swapping method successfully applied to complex organic structures—new possibilities for drug design Skeletal editing is a modern approach to chemical synthesis. By making precise alterations at the atomic level, researchers are able to directly convert existing drug scaffolds into new, biologically relevant compounds.

✨Atomic alchemy! Scientists are *rewriting* drug blueprints at the molecular level, forging new medicines from existing ones.🤯 #SkeletalEditing

Source: phys.org/news/2025-05-atom-swappi...

Skeletal editing targets double bonds Two new techniques selectively install nitrogen atoms into complex molecules

Skeletal editing targets double bonds #Science #Chemistry #OrganicChemistry #SkeletalEditing #DoubleBonds