Streamlined marine alkaloid syntheses 🌊🔬 Kaliappan & co-workers report concise #TotalSynthesis of denigrins E & D, plus formal syntheses of polycitones A & B⚡ Microwave-assisted Paal–Knorr pyrrole formation powers these high-yield, step-economical routes🚀

👉 buff.ly/TGcfeH8

Dive into the chemistry of #cotylenin & #fusicoccin ✨ Discover how they modulate 14-3-3 protein–client interactions and check out the divergent syntheses of brassicicene & talarmalnoid B using Studer’s Mukaiyama hydration by Shenvi @shenvi.bsky.social & co-workers
#TotalSynthesis

👉 buff.ly/eVPZoqE

Total synthesis of mono-rhamnolipids using organophotoacid-catalyzed glycosylation and their antibacterial activity, published by ChemComm, Royal Society of Chemistry

On cover✨| ChemComm
慶應義塾 高橋大介、戸嶋一敦先生らによる、モノラモノリピッドの全合成🧪🦠 @chemcomm.rsc.org

Total synthesis of mono-rhamnolipids using organophotoacid-catalyzed glycosylation and their antibacterial activity
pubs.rsc.org/en/content/a...
#naturalProducts #totalSynthesis

Controlling epoxide #cyclizations like never before🌀
Vanderwal & co-workers explore α-alkoxy #epoxides in Nugent–RajanBabu reductive cyclizations, revealing how α-oxygen protecting group size dictates 6-endo vs 5-exo outcomes⚗️
#TotalSynthesis

👉 buff.ly/XJnLZ1c

In this review, Zhiqiang Ma and co-researchers focus on the applications of enantioselective #desymmetrization of prochiral 1,3-diols in the synthesis of natural products and biologically active molecules. 
➡️ https://tinyurl.com/wjrztj83
#AsymmetricSynthesis #NaturalProduct #TotalSynthesis
#BJOC 💎🔓

Michalak & Vanderwal report a clever, Cl-guided stereocontrolled formal synthesis of Steviol — using a removable chlorine center and epoxide-initiated bicyclization for precise stereochemistry🔄⚗️
#terpenoids #TotalSynthesis

👉 buff.ly/Q2ize6T

🏆 TOP 5 Most Downloaded Articles of 2025!
A practical, scalable synthesis of the #NaturalProduct (±)-tylophorine🧪 Masal & Reddy report a protecting-group-free route from readily accessible starting materials featuring key cyclization & Clemmensen steps.
#TotalSynthesis

👉 buff.ly/BcrAXq8

Just accepted✨ | Chemical Science
理化学研究所 橋本卓也先生らによるSe-Catalyzed Enantioselective Lactamization Enabled by a N-Fluorosulfonyl Group: Total Synthesis of Diaporisoindole A🧪
pubs.rsc.org/en/Content/A...
#totalSynthesis

The thematic issue “Concept-driven strategies in target-oriented synthesis” ed. by David Yu-Kai Chen, Chao Li and Yefeng Tang in the #BJOC is complete. 
A huge thank you to the authors for their insightful contributions 🙏
👉 https://tinyurl.com/2rhvpube
#TotalSynthesis #TargetOrientedSynthesis

Paul Knochel · ©Société Chimique de France

🎁HBT Paul Knochel (LMU Munich), who turns 70 today—unbelievable knowing his charming boyish appeal. Developing new synthetic methods, in particular based on organometallic compounds, and applying them in the #TotalSynthesis of natural products has become a hallmark of the Knochel group.

Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis

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A protecting group-free, 4-step total synthesis of (±)-β-eudesmol in 25% yield by Pulukuri & co-workers!🚀 Highlights include a Cu-catalyzed Michael–aldol cascade and a one-step Fe(III)-mediated radical cyclization–oxidation to build the eudesmane core🧪
#TotalSynthesis

👉 buff.ly/c7upFCj

✨Bürgenstock Special Section 2023✨

First enantioselective #TotalSynthesis of lucidumone in 13 steps🍄! Aurélien de la Torre @auredelatorre.bsky.social & co-workers use a retro-[4+2]/#DielsAlder cascade to access this COX-2 selective #meroterpenoid

👉 buff.ly/O6SQ8Os

Unlocking complex spirocyclic oroidin #alkaloids like palau’amine🔬 Carl Lovely & co-workers report a novel Diels–Alder sequence with tandem #TBAF desilylation, oxidation & rearrangement to create a versatile intermediate for #TotalSynthesis.
#cycloaddition

👉 buff.ly/mi6k9Sl

Deadline extended to 📅 Oct 31, 2025
There’s still time to submit to the thematic issue “Concept-driven strategies in target-oriented synthesis” edited by David Yu-Kai Chen, Chao Li & Yefeng Tang: 🔗 https://tinyurl.com/2rhvpube
#TotalSynthesis #BJOC 💎🔓
@tsinghuauniversity.bsky.social

Epoxyquinoids herpotrichones A–C possess unique 6/6/6/6/3 pentacyclic frameworks and exhibit potent neuroprotective effects
#totalsynthesis #ChemSky

pubs.acs.org/doi/10.1021/...

In this review, Professor Zhang et al. highlight recent advancements in #enamide-based cyclization reactions w/ an emphasis on their pivotal role as a strategy in the #TotalSynthesis of #NaturalProducts. 
➡️ www.beilstein-journals.org/bjoc/articles/21/81
#alkaloid #cyclization 
#BJOC 💎🔓

Congrats to all of the authors, in particular to Florian Kromm and Søren Borcher Møller who lead this work together. 👏 We are grateful for the @erc.europa.eu opa.eu for funding.
#totalsynthesis

📢 Invitation to submit to the thematic issue “Concept-driven strategies in target-oriented synthesis” edited by David Yu-Kai Chen, Chao Li & Yefeng Tang 🔗 https://www.beilstein-journals.org/bjoc/series/143?B=y
#TotalSynthesis #SyntheticChemistry #BJOC 🔓  
@tsinghuauniversity.bsky.social

Total Synthesis of (+)-Ansatrienol K The first total synthesis of ansatrienol K, a novel trienomycin congener featuring a diene moiety within its 19-membered macrolactam ring, is reported. Key steps include two sequential palladium-catalyzed cross-coupling reactions for constructing the trisubstituted benzene ring and two distinct strategies for assembling the C6–C18 fragment. A Co2(CO)8-catalyzed carbonylative epoxide ring-opening provided the diene fragment, while late-stage Stewart–Grubbs catalyst-mediated diene-ene ring-closing metathesis (RCM) enabled efficient macrocyclization.

Diene-En Ring-Closing Metathesis has regioselectivity and cis/trans selectivity challenges. Jin-Ming Gao and colleagues from Northwest A&F #University showed it can be effective with their #totalsynthesis of ansatrienol K in the Journal of Organic Chemistry.
pubs.acs.org/doi/full/10....

#chemistry

Finding a symphony among complex molecules MOSAIC scholar Stanna Dorn uses total synthesis to recreate rare bacterial natural products with potential therapeutic applications.

"We try to help access these molecules not only in an efficient way but also in a creative way in order to expand chemical knowledge about how we put molecules together."
—Stanna Dorn, a #postdoc in @reiswoman.bsky.social's lab
ow.ly/MIqh50VHRHk
#TotalSynthesis #OrganicChemistry #ASBMBMOSAIC

🧪 Explore this paper by Emmanuel Roulland & co-workers on the synthesis of the complex polyketidic macrolactam of incednine! This work advances #TotalSynthesis strategies such as a Pd-catalyzed cross-coupling and Horner–Wadsworth–Emmons olefination

👉 buff.ly/N3niEoF

One Step #TotalSynthesis of Arenicolin B from @yitangucla.bsky.social and coworkers

chemistry-europe.onlinelibrary.wiley.com/share/ZRCIH7...

Huck Grover in front of summary slide with title “Summary of Diazo Cascade”

It’s March break, but chemistry keeps coming to UNB! Huck Grover from @memorialu.bsky.social walking us through a Diazo cascade during their Atlantic Seminar series. #chemsky #totalsynthesis

Total synthesis of anti-addictive alkaloid in just seven steps A streamlined synthesis of the psychoactive compound ibogaine could open up new opportunities in the treatment of drug addiction and depression

Total synthesis of anti-addictive alkaloid in just seven steps #Science #Chemistry #OrganicChemistry #TotalSynthesis #Alkaloids

Original post on mstdn.social

Novel enantioselective #synthesis of rubriflordilactone B by Gui and colleagues from the Chinese Academy of Science published in #JACS
This is already the second total synthesis of this group, with an interesting reaction cascade as the key reaction in this process.

#chemistry #science […]

Convergent Total Synthesis of Aleutianamine Joseph P. Tuccinardi, John L. Wood JACS 2025 asap doi: 10.1021/jacs.4c12946

Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling […]

[Original post on mstdn.social]

Go check out how Debendra K. Mohapatra and team achieved the first asymmetric total synthesis and structural confirmation of lobophopyranone A and B from commercially available starting materials! 🔬💡
#TotalSynthesis

Learn more 👉 https://buff.ly/4ghzWKM

Biosynthesis of the Antifungal Polyhydroxy-Polyketide Acrophialocinol Bioactivity-guided isolation identified the main antifungal compounds produced by Acrophialophora levis as the new polyhydroxy-polyketides acrophialocinol (1) and acrophialocin (2). Their biosynthesis was elucidated by heterologous reconstitution in Aspergillus oryzae and involves an α-ketoglutarate-dependent dioxygenase-catalyzed α-hydroxylation, resulting in the formation of a tertiary alcohol that is indispensable for antifungal activity. Furthermore, self-resistance toward the polyhydroxy-polyketides is mediated by a conserved RTA1-like protein encoded in the acr biosynthetic gene cluster.

One Step #TotalSynthesis of Acrophialocinol

pubs.acs.org/doi/full/10....

Not all cytochrome b5s are created equal: How a specific CytB5 boosts forskolin biosynthesis in Saccharomyces cerevisiae Cytochrome B5s, or CytB5s, are small heme-binding proteins, ubiquitous across all kingdoms of life that serve mainly as electron donors to enzymes eng…

1 step #TotalSynthesis of Forskolin. 1.8 g/L

www.sciencedirect.com/science/arti...