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Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks–What about specialised metabolism? In recent years, genome sequencing of filamentous fungi has revealed a high proportion of specialised metabolites with growing pharmaceutical interest. However, detecting such metabolites through in s...

This is my second article in #SystemBiology applied to #NaturalProduct discovery with D. Nègre and A. Larhlimi. the first one was: "Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks–What about specialised metabolism?"
doi.org/10.1371/jour...

Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 GATA-3 serves as a key transcription factor driving Th2 cell differentiation and allergic cytokine production. Identifying the natural modulators of GATA-3 could provide therapeutic opportunities for the regulation of allergic responses. This study aimed to identify Vitis amurensis-derived natural products with strong GATA-3 inhibition and to elucidate their binding modes and mechanisms of action. The DNA-binding domain 2 (DBD2) of human GATA-3 was analyzed by using NMR spectroscopy, including backbone assignment. Isolated natural compounds were screened for binding activity, followed by reporter gene assays to evaluate the transcriptional inhibition potential. Two-dimensional NMR and docking studies were conducted to characterize binding interactions and identify binding sites. Stilbenoids from V. amurensis showed specific binding to the DNA-binding domain of GATA-3, as detected by 2D NMR. Reporter gene assays revealed dose-dependent transcriptional inhibition by these compounds. One of the hit compounds, KUP149, exhibited two binding modes on DBD2 based on NMR data, both of which can disrupt GATA-3–DNA interactions. These findings suggest stilbene-based natural products as potential inhibitors of allergic immune responses via GATA-3 modulation.

Our wonderful article has been published in Journal of Natural Product #acs #naturalproduct #GATA3
Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3 | Journal of Natural Products pubs.acs.org/doi/10.1021/...

🍇 NMR Chemical Shifts of Common Flavonoids 🍇

📄 This #OA study explores how three #NMR solvents may be used as a reference for isolated compounds, for detecting #flavonoids within mixtures like plant extracts as reference data for #NaturalProduct databases.

🔓 www.thieme-connect.de/products/ejo...

RESEARCH FELLOW | U-M Careers

#Postdoc job opportunity: The Pereira lab at the LSI is seeking a postdoctoral researcher help develop cutting-edge experimental and computational approaches to accelerate #NaturalProduct discovery. Learn more and apply:
careers.umich.edu/job_detail/2...

In this review, Zhiqiang Ma and co-researchers focus on the applications of enantioselective #desymmetrization of prochiral 1,3-diols in the synthesis of natural products and biologically active molecules. 
➡️ https://tinyurl.com/wjrztj83
#AsymmetricSynthesis #NaturalProduct #TotalSynthesis
#BJOC 💎🔓

Expanding the actinomycetes landscape for phosphonate natural products through genome mining Phosphonate natural products (P-NPs) represent a unique and underexplored class of bioactive compounds with significant pharmaceutical and biotechnological potential. Many novel P-NPs with promising b...

How can #GenomeMining accelerate the discovery of phosphonate #NaturalProduct producers?🦠

New research from @leibniz-dsmz.bsky.social and @unituebingen.bsky.social highlights actinomycetes as a rich source of novel bioactive phosphonates.

👉Read the full article here doi.org/10.1039/D5CB...

The website for this event is ready in here:
htuh.uudoon.in #naturalproduct

🏆 TOP 5 Most Downloaded Articles of 2025!
A practical, scalable synthesis of the #NaturalProduct (±)-tylophorine🧪 Masal & Reddy report a protecting-group-free route from readily accessible starting materials featuring key cyclization & Clemmensen steps.
#TotalSynthesis

👉 buff.ly/BcrAXq8

Just Published✨ | Chemical Science
RIKEN高橋俊二先生、東北大学土井隆行先生らによる
Characterization of the ketoreductase domain of pikromycin module 2
pubs.rsc.org/en/content/a...
#naturalProduct #medicinalChemistry

Our natural product of the week comes from the festive red berries of the common holly (Ilex aquifolium)! This plant contains fascinating bioactive compounds, including #anthocyanins, which contribute the festive red color of the berries

#GrowingTogether #NaturalProduct #MedicinalPlant

A bright collage of smiling children and families holding Nutramin vitamin bottles. Each person proudly shows off the gummies, radiating joy and health. The image features the tagline “Real People. Real Ingredients. Really yummy vitamins.” with the Nutramin and Nutracelle logos on a pink background.

Real people, real ingredients, and really yummy vitamins. 💜

Nutramin makes family wellness something everyone can smile about!

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A smiling mom and daughter sit together in a cozy kitchen with a bottle of Nutramin Kids Multi Gummies on the counter, symbolizing easy, family-focused wellness.

Small steps lead to big change — like choosing vitamins your whole family actually loves.

Healthy can be simple. Healthy can be yummy. 💜

#WellnessMadeEasy #Nutracelle #Vegan #SugarFree #TheBetterWayToVitamin #CanadianMade #NaturalProduct #Wellness #Vitamins #Vegan #BuyCanadian #ProudlyCanadian

Healthy habits taste better when they’re made with real ingredients. 🌿

Nutramin vitamins are crafted with apple pectin and natural fruit flavors — never gelatin or artificial anything.

#BetterWayToVitamin #VeganWellness #Nutramin #CanadianMade #BuyCanadian #NaturalProduct #SugarFree #Vitamins

Read this superb thread if you are interested in #microbialevolution #foodmicrobiology #cheeseproduction #naturalproduct #whytoarchivemicrobialsamples or you just want to learn about this cool cheese rind microbiome project published from @benwolfe.bsky.social lab

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Head to www.jamienatural.com to plan your #naturalproduct shopping spree.
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