Actinomycetes under the spotlight: screening 940 genomes revealed 54 candidate phosphonate producers, with 21 strains confirmed, including Kitasatospora fiedleri carrying a unique, regulator controlled biosynthetic cluster.
Learn more: tinyurl.com/y43tk58n

#Phosphonate #Actinomycetes #GenomeMining

Expanding the actinomycetes landscape for phosphonate natural products through genome mining Phosphonate natural products (P-NPs) represent a unique and underexplored class of bioactive compounds with significant pharmaceutical and biotechnological potential. Many novel P-NPs with promising b...

How can #GenomeMining accelerate the discovery of phosphonate #NaturalProduct producers?🦠

New research from @leibniz-dsmz.bsky.social and @unituebingen.bsky.social highlights actinomycetes as a rich source of novel bioactive phosphonates.

👉Read the full article here doi.org/10.1039/D5CB...

🚨 New Preprint Alert 🚨

Proud of @elenadelpup.bsky.social for posting her preprint on plantiSMASH 2.0 👏 Find out all about it and links to give it a try in her thread 👇

#genomemining #plants #geneclusters #naturalproducts #discovery
#ProudPI
@w-u-r.bsky.social

ZiemertLab The Ziemert lab is interested in the evolution and distribution of bacterial secondary metabolites. These bioactive compounds are especially important in human medicine as the chemical scaffolds are t...

Check out the Ziemert Lab’s new YouTube channel
m.youtube.com/@ZiemertLab
We’ve uploaded short tutorial videos on how to use our tools for genome mining and natural product discovery.
Thanks Semih, @martinaadamek.bsky.social @turgutmesut.bsky.social ! #GenomeMining #SecMet #naturalproducts

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis Most biosynthetic gene clusters remain uncharacterized, making it difficult to predict their functions and activate their expression. Using an innovative approach that integrates regulatory network an...

New publication: #Genomemining based on transcriptional regulatory networks uncovers a novel locus involved in #desferrioxamine biosynthesis, by @gillesvanwezel.bsky.social and others.
doi.org/10.1371/jour...

Big thanks to the team @Rothamsted, collaborators, and funders @BBSRC as part of the Growing Health Institute Strategic Programme.
Feedback welcome!
#preprint #microbiology #secondarymetabolites #genomemining #plantpathology

And more #NaturalProduct #GenomeMining with Eric Helfrich from @goetheuni.bsky.social who is targeting the fascinating "unknowns" side of Rumsfeld's Matrix! His lab is mining atropopeptide and non-canonical terpenoid biosynthetic gene clusters with #AI-driven #ML-based predictions. #IPBSymposium2025

Now, @nadineziemert.bsky.social is showing how she predicts #NaturalProducts diversity in bacteria with #ComputationalGenomics #GenomeMining. Check out some of her tools:
🛠️ bgc-atlas.cs.uni-tuebingen.de
#GeneClusters
🛠️ automlst2.ziemertlab.com
#Phylogenies
🛠️ arts.ziemertlab.com
#Antibiotics

Our paper on #biosynthetic genes coding for ribosomal #peptides is out now: rdcu.be/ekux7! We present the 1st report of #RiPP-BGCs presence & diversity in #lichens. Spoiler: they’re ubiquitous & make up ~15–20% of #BGCs. #secondarymetabolites #fungi #genomeMining

Amphibian skin bacteria contain a wide repertoire of genes linked to their antifungal capacities - World Journal of Microbiology and Biotechnology Emerging diseases caused by fungi are a serious threat to wildlife biodiversity. The widespread fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused dramatic amphibian population declines an...

Happy to share some of my PhD results at UNAM CCG
! #Ambystoma #Chytridiomycosis #Amphibian #skinmicrobiome #Botrytiscinerea #genomemining #antifungal #axolotl
link.springer.com/article/10.1...

Available online - the Spotlight "Journey to the past: #MolecularDeextinction enables the discovery of ancient β-#defensins and highlights their evolutionary history" from @fgosti.bsky.social.

#moleculardynamicsimulation #genomemining #antimicrobialpeptides

authors.elsevier.com/a/1kK%7EK3S6...

Does anybody know if Bluesky feeds into @altmetric.com yet?

This seems an important step to make this platform a viable replacement to X for scientists

#secmet #natprod #genomemining #science

1/3
Precomputed SocialGene database dumps are now available on AWS for free download (>340k genomes, >2 million BGCs, etc.)

#knowledgegraphs #genomemining #secmet

www.biorxiv.org/content/10.1...
registry.opendata.aws/socialgene/
socialgene.github.io/precomputed_...

That was a great MARBLES EU Project meeting nearby Copenhagen, Denmark - great science & great food, nice people, a wonderful location, and breakfast with a view 😎 Many thanks to Lone Gram & Gilles van Wezel for the coordination! #genomemining #metabolomics #marine #microbiology

Next step: "Hacking" the biosynthetic genes to create novel specialised metabolites #NaturalProducts #GenomeMining