Bitter Reception Gentiana lutea

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#Plant #secmet #natprod #ChemSky

Synthetic biology for heterologous expression and engineering of fungal polyketide synthases Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…

🔓Take a look at this #OpenAccess Highlight article from Pablo Cruz-Morales & co. @wemakemolecules.bsky.social discussing synthetic biology for heterologous expression and engineering of fungal polyketide synthases #secmet #natprod

📍 @dtu.dk

Is Glycyrrhizin a Prodrug Therapeutic Activity of Licorice (Glycyrrhiza glabra) Root

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#Plant #secmet #natprod #ChemSky

Streptomyces as a versatile host platform for heterologous production of microbial natural products Focus on 2004 to 2024 The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for…

🔓Be sure to read in our latest issue this #OpenAccess review by Andriy Luzhetskyy & co. @uni-saarland.de examining the use of Streptomyces as a versatile host platform for heterologous production of microbial natural products #secmet #natprod

Find the full article here🔽

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Don't miss this #OpenAccess Viewpoint by @philmuslab.bsky.social & co. discussing the challenges & solutions to unlocking the potential of cyanobacteria in drug discovery #secmet #natprod

Check it out in full below👇

Effective Phytochemical Variance Ratio Structure and Clinical Endpoints

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#Plant #secmet #natprod #ChemSky

Enhanced Absorption and Product Labeling A Student Assignment

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#Plant #secmet #natprod #ChemSky

Did anyone else pick up a horrific cold at the Marine Natural Products Gordon Conference? Hopefully I just got it traveling back. (Neg for COVID and flu). 3 days of fever starting Sunday, and I'm still barely functional, today. Sucks to be getting old and slow to recover. This is ridiculous.
#secmet

🎉We are delighted to announce that the 2026 Natural Product Reports Emerging Investigator Lectureship has been awarded to Jakob Franke (@unihannover.bsky.social)

Please join us in congratulating him! #chemsky #natprod #secmet

Read more about Jakob and his research🔽
blogs.rsc.org/np/2026/03/1...

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Take a look in our latest issue at this #OpenAccess review by Stephanie Heard & Alessandra Eustaquio @eustaquiolab.bsky.social looking at the development of Burkholderia bacteria as heterologous hosts #natprod #secmet

📍 @uofilsystem.bsky.social
pubs.rsc.org/en/content/a...

Ashwagandha Dosing, Part II: Rethinking Dose

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#Plant #secmet #natprod #ChemSky

Ashwagandha Dosing, Part I Is the evidence insufficient?

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#Plant #secmet #natprod #ChemSky

Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering Covering: up to 2025. Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and pharmacologically potent natural products,…

Be sure to read this review by Kenan Bozhüyük & co. @helmholtzhips.bsky.social highlighting the tools and strategies for NRPS and PKS pathway exploration and engineering in our latest issue #natprod #secmet

Find the full article below👇

🔓Don't miss the #OpenAccess Highlight behind the cover of our latest issue by Francesco Del Carratore & Rainer Breitling @liverpooluni.bsky.social & @manchester.ac.uk on how microbiomes can be engineered for natural product discovery and production #secmet #natprod

pubs.rsc.org/en/content/a...

Fermentation as an Extraction Method Recovering Traditional Techniques for Today's Herbal Product Needs

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#Plant #secmet #natprod #ChemSky

🚨Early Career Researchers!🚨
Grad students, undergrads, post-docs, technicians!

Our summer conference has a lot of great opportunities to present your work, network with other great #secmet #botany #medicinalplant scientists, and even win some 💵!

Come join us in Hershey PA this June!

I forgot to ad hashtags!! #Biosynthesis #Olive #plantscience #NaturalProducts #SecMet
I may have to repost this later this week; anyone know hashtags on natural product biosynthesis or enzyme/gene discovery?

Does Changing Form Alter the Clinical Uses of Medicinal Plants Red Clover Extraction, Stability, Absorption, and Clinical Endpoint

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#Plant #secmet #natprod #ChemSky

📢Our latest issue is now online!

This month's issue is a special themed collection on Microbial Host & Metabolic Engineering for Natural Product Discovery & Production #secmet #natprod #chemsky

Read the articles in the collection on our website here🔽
pubs.rsc.org/en/journals/...

Overview of the paper in cartoon form

We are delighted to share our vision in #RSCChemBioy of how to incorporate natural product discovery (and any drug discovery) into the framework of personalized medicine - drug discovery using patients, but not in patients! #natprod #secmet pubs.rsc.org/en/content/a...

💙🌊 Saccharomonospora cyanea isolated from the Clarion-Clipperton Zone (CCZ) by @zmaw.bsky.social #actinomycete #deepsea #secmet

Engineering class I terpene synthases for skeletal diversity: strategies and applications Covering: up to August 2025 Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications in medicine, agriculture, and fragrance…

Don't miss a review by Liao-Bin Dong & co. at the China Pharmaceutical University in our latest issue examining the strategies and applications for engineering class I terpene synthases for skeletal diversity #natprod #secmet

Check out the full article on our website🔽

Paclitaxel saved my life. New discoveries could boost supply After decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug

Lovely C&EN @cenmag.bsky.social story on the history and personal impact of the cancer drug Taxol. After spending recent years deciphering how yew trees, our source for Taxol, synthesize this lifesaving drug, it’s so nice to see it in the larger context #secmet #medsky
Plants are amazing chemists.

OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II | Applied and Environmental Microbiology Bioactive microbial natural products remain the preeminent source of new lead compounds for drug development. Due to the increasingly high levels of strain and compound rediscovery from terrestrial en...

Check out our paper in @asm.org Applied and Environmental Microbiology 🍾

OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and the antimicrobial thiazole alkaloid agrochelin II | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...

#secmet #microsky

An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs).…

Read in our latest issue a paper by @rokaslab.bsky.social & co. from @vanderbilt.edu & @uncg.edu describing an integrative chemical & genomic similarity approach to link fungal secondary metabolites & biosynthetic gene clusters #natprod #secmet

Find it in full here🔽

#secmet

Congrats, Marnix!
#secmet

Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis Covering: up to 2025 Cardiac glycosides (CGs), a class of metabolites found in nature, comprise sugar residues, unsaturated lactone rings, and steroidal cores. As renowned phytotoxins, they play…

Take a look at a review by Shuang Liu, Ping Su, Luqi Huang & co. in our latest issue providing an overview of the structural diversity, chemical ecology, bioactivity & artificial synthesis of cardiac glycosides #natprod #secmet

📍China Academy of Chinese Medical Sciences

Fermentation Scientist I Job Opening: Fermentation Scientist I at Bactobio in London.

We're looking for a Fermentation Scientist to help scale up production of our bioactive metabolites. If you've got experience with secondary metabolites, bioreactors, and culture condition optimisation give it a look! #secmet #natprod bactobio.pinpointhq.com/en/postings/...

Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis Covering: 1948 to 2025 Ryanodane diterpenes (RDs) are a unique class of plant-derived natural products characterized by their complex, polyoxygenated pentacyclic frameworks. They have been primarily…

Don't miss this review in our latest issue by Yu Zhang et al. from the Kunming Institute of Botany looking at the occurrence, structural diversity, bioactivities and synthesis of ryanodane diterpenes #natprod #secmet

Check out the full article below👇