Great to see all the updates you are posting, keep it coming!

The stiffness is likely just reflecting the inflammation?

The current administration’s narrative that Harvard (and all universities) feel “entitled” to federal dollars misleads the public. Nor are these funds a “privilege” 1/n

Introducing our single-cell DVP framework combining strategic cell selection with protein gradient mapping algorithms. Analyzing hepatocyte proteomes across 18 human livers, revealing cross-species differences, and mapping disruptions in liver fibrosis.
www.biorxiv.org/content/10.1...

Battle of the biopsies: Role of tissue and liquid biopsy in hepatocellular carcinoma The diagnosis and management of hepatocellular carcinoma (HCC) have improved significantly in recent years. With the introduction of immunotherapy-based combination therapy, there has been a notable e...

We do not routinely biopsy but we are doing it more often than before.

I am big proponent for biopsy before systemic therapy as wrote in this review pmc.ncbi.nlm.nih.gov/articles/PMC....

But I still do not think the evidence is strong enough to make it into the guidelines.

A practical review of new AGA guidance on PVT management by @drjessicadavis.bsky.social
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD

The first ever @fda.gov approved treatment for IgG4-RD is upon us. #inebilizumab #uplizna @amgen.bsky.social
A much needed option for this very heterogenous and challenging disease which can literally affect any organ but prominently liver and bile ducts.
#liversky #gisky

Congrats to Thailand for nearly eliminating vertical transmission of hepatitis B

The vaccine works

doi.org/10.12932/ap-...

A spatially resolved transcriptome landscape during thyroid cancer progression Liao et al. integrate spatial transcriptomics and scRNA-seq to map thyroid cancer progression. They identify distinct thyrocyte subpopulations and tumor-stage-specific cell-cell interactions, highlighting SERPINE1+ fibroblasts as potential markers of malignancy. Their findings provide a spatially resolved view of tumor microenvironment remodeling in thyroid cancer.

Online now: A spatially resolved transcriptome landscape during thyroid cancer progression Online now:

Anything new happened there?

A metric that reflects reality and the @bluesky platform as the preferred one to transmit science publications with collegial communication

Two truths and a lie

Truth: There are adverse events from MMR and all vaccines.

Truth: People die, albeit very, very, VERY rarely.

BIG FUCKING LIE: the MMR does NOT cause measles or any sequelae. It prevents measles. It’s safe and effective. Measles disables & kills children. Vaccinate your kids

AASLD is here

@aasldnews.bsky.social
@aasldfoundation.bsky.social

#liversky

Calling #liversky 📣📣📣

Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current guidelines - PubMed In our series, a high proportion of AMA positive patients with normal ALP levels have PBC. For the first time we show histological diagnosis of PBC in AMA-negative/PBC-specific ANA-positive subjects a...

Interesting, what was the GGT? I haven’t seen this in my practice, but apparently can happen rarely, here is a nice study pubmed.ncbi.nlm.nih.gov/33229138/

Biggest?!

In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.

What happened

SCI Member Hanlee Ji & others found that #GastricCancer precursors exhibit variable progression rates. A 26-gene panel was identified, linked to advanced lesions, suggesting immature intestinal cells play a key role in carcinogenesis. www.nature.com/articles/s41...

Why not treat all the large varices? Is the idea to decrease risk of post banding ulcer bleed? And unless it’s actively spurting at the time of scope, it’s not always obvious which the bleeder is, right?

48 Scientific Societies Representing Almost 100,000 Scientists Ask Congress to Protect the Future of Science 48 scientific societies representing almost 100,000 scientists signed on to a letter asking Congress to protect the future of science

Today, a broad coalition of scientific professional societies who represent over 92,000 scientists are speaking out against the politicization and demonization of Federally funded science and government scientist jobs.

It was an honor to help the Union of Concerned Scientists with this! 🧪🌎

Highlighting role of hepatology in the spectrum of HCC care
In this study
Impact of liver decom on clinical outcomes on atezobeva
📌OS better in CP A vs CP B
📌No differences in TTP/safety
📌Liver decomp: 28% CP A vs 51% CP B
📌41% resume after decomp
#Liversky
www.cghjournal.org/article/S154...

A vertical image of a region of a molecular cloud. The orange cloud is dense and bright close to the top right, where it also appears like rolling clouds, and grows darker and more wispy toward the bottom and in the top left corner. One bright star with six short diffraction spikes and several dimmer stars are visible among the clouds.

Resembling sand swirling in water, this region of a molecular cloud was observed by #NASAWebb. In mid-infrared light, several dim stars and one bright star with diffraction spikes appear.

Credit: NASA, ESA, CSA, W.R.M. Rocha (LEI). 🔭 🧪

A whole series dedicated to HCC ❤️

#LiverSky
@freddyeescorcia.bsky.social

It affects all of us!

Tell Congress to Stop Harmful NIH Research Cuts! Tell Congress to Stop Harmful NIH Research Cuts!

Presently, an estimated 60-70 million Americans are suffering from GI diseases. That is why consistent and sustainable funding from NIH is necessary to support innovative research and treatment development.
Please take a minute to tell Congress to stop NIH cuts!
gastro.quorum.us/campaign/109928

U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

A whole generation of early career scientists and physician-scientists, including colleagues and myself, are particularly vulnerable to these funding freezes and cuts, with jobs and careers depending on federal grants.

#IDsky
#Medsky
#Episky

www.science.org/content/arti...

Safety and efficacy of a defined bacterial consortium,... : Hepatology Communications thods: We performed a single-center, randomized, placebo-controlled trial of VE303 in adult patients with a history of overt HE (NCT04899115). Eligible patients were taking lactulose and rifaximin, ...

This trial by @bloompringle.bsky.social will be seen as one of the most important in the field of FMT - 💩 transplant - for #cirrhosis

Does the 💩 engraft?
Does the 💩 work (improved barrier function)?

This is why PPB is the future

journals.lww.com/hepcomm/full...

#liversky

Inspired by Herblock.

@NIH needs thoughtful, deliberate, transparent, and accountable reform.
Not this chaos!

Instead of uniting, many are exploiting the crisis to push their own agendas.

This division leaves our community fractured while decades of progress is being recklessly discarded!

Let’s unite our voices !

Hiring Alert!

We’re looking for a fellow to join our lab at @Stanford_GI and work on cutting-edge research in liver cancer immunobiology.

Help me spread the word, know someone interested? Send them my way! #HCC

postdocs.stanford.edu/prospective/...