Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Tumour promotion through the lens of evolution Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

Tumor promotion through the lens of evolution

This review grew out of many long conversations, shared ideas, and lively discussions

It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk

rdcu.be/fdC2J

Interested in a PhD Fellowship in our Lab?
Check out the new #IRBBarcelona call:

Our team at #EMBLCanGen in Heidelberg!
Raquel Blanco gave a brilliant talk, and we had great poster presentations from Elisabet Figuerola, Olivia Dove, Ferran Muiños, Rocio Chamorro, and Axel Rosendahl. 👏
Thanks to @events.embl.org for organizing such a high-quality event in Cancer Genomics!

Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona.
The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

🧪 Out in @nature.com:  Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

 ✍️ #IRBBarcelona & University of Washington

📌 DOI: 10.1038/s41586-025-09521-x

Video credits: 3CatInfo, Som3cat

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

Ultra-sensitive DNA sequencing maps mutations that precede cancer Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer

go.nature.com/42vakWS

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.

Read more: www.cancergrandchallenges.org/news/early-c...

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

✍️ #IRBBarcelona & University of Washington

➡️ bit.ly/42wcIN5

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧵👇

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey!

🧵Summary following ⬇️

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Diagram illustrating the two-hit model of retinoblastoma

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

Our colleagues Olivia Dove, Raquel Blanco and Ferriol Calvet are attending the #EACR2025. They are sharing their research results with their respective posters and are for sure learning a lot in an excellent Congress with an outstanding list of speakers. @ferriol.bsky.social @raquelbmi.bsky.social

Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!

This is figure 6, which shows within-species subclades associations with CRC, tumor staging and primary location.

An analysis in Nature Medicine confirms that the microbiome can be a clinical target for colorectal cancer screening and characterizes it as a biomarker for colorectal cancer progression. go.nature.com/3Hrux8m #medsky 🧪 🧬

🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟

Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻

See offer here 👉 jobs.vhio.net/en/jobs/6016...

#Bioinformatics #SingleCellRNA #Immunogenomics

Kudos to @raquelbmi.bsky.social and @ferriol.bsky.social, first authors of the study, for the insane amount of good work put into this.

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer Nature Genetics - Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution...

Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️

Congratulations Victor and team!!

Join us in beautiful Barcelona!!

OpenVariant: a toolkit to parse and operate multiple input file formats AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social

doi.org/10.1093/bioi...

Hi Bluesky! Nice to see the scientific community growing here 🤗