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Posts by Takahiro Maeda

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Excited to share our new paper in Blood (@bloodjournals.hematology.org), where we explore how XPO7 (Exportin 7) and histone gene regulation intersect with p53 functional status in AML. Congrats to Yuichiro and the team! ashpublications.org/blood/articl...

5 months ago 2 0 0 0

very intersting work!

6 months ago 0 0 0 0
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An mRNA Crime

An mRNA Crime | Science | AAAS www.science.org/content/blog...

8 months ago 2 0 0 0

A beautiful review by Stu Orkin—a true giant in transcriptional regulation, hematopoiesis, and sickle cell research!

10 months ago 6 0 1 0
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Mutations that stick: Unexpected discovery of molecular glue mimicry Recent elegant studies in Nature uncovered an unprecedented molecular glue-like mechanism of action for the preclinical drug UM171. This small molecule showed striking functional and structural similarities to brain-cancer mutations that prompt neomorphic protein interactions. This phenomenon of chemical-genetic convergence could be reverse-engineered to aid the rational design of induced proximity therapeutics.

Mutations that stick: Unexpected discovery of molecular glue mimicry

1 year ago 2 2 0 0
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Healing My Family’s Future How genetics and IVF empowered a family to leave cancer behind.

A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...

1 year ago 3 2 0 0
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...

1 year ago 36 8 0 0
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A new ‘mini-CRISPR' flexes its editing power in monkey muscles The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases

A miniaturized #CRISPR system can edit DNA in monkey muscle, according to a new preprint.

1 year ago 61 7 1 1

So proud of @katie-maurer.bsky.social and Cameron Park for showing the power of combining innovative #ML with what we call "Katie Intelligence" (our domain expert in the loop 👩‍🔬) for building impactful computational tools and applying them to obtain unexpected clinical insight!

1 year ago 11 3 2 0
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All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

1 year ago 12244 4979 586 1165

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below!

go.bsky.app/EY3k2bE

1 year ago 8 5 8 0

Thanks for making this pack available. Great idea! Please add me to the list.

1 year ago 1 0 1 0