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Posts by Dinos Meletis

Update on Wellcome LEAP's $50 million program on autism and the microbiome Exactly five months ago, I blogged about a program entitled Foundations of a Resilient Microbiome (FORM) that Wellcome LEAP was funding to ...

New blogpost by @deevybee.bsky.social on Wellcome LEAP's $50 million program on autism and the microbiome deevybee.blogspot.com/2026/03/upda...

3 weeks ago 14 7 1 2
Capturing Spatially Organized Oscillatory Cliques as Signatures of Neuronal Assemblies State-of-the-art neural recording technologies now enable dense sampling of neuronal activity, demonstrating meaningful spiking variability from moment to moment. Yet spiking activity is sparse by nature and allows only partial access to collective neuronal dynamics. Local field potentials (LFPs) provide complementary information by capturing coordinated activity from large neuronal populations, but methods to characterize the fine-scale spatio-temporal organization of LFPs are lacking. Starting from the notion that neural oscillations are brief and burst-like, we introduce a framework to detect and analyze SPatially Organized Oscillatory Cliques (SPOOCs), oscillatory events that are cohesive in space, time, and frequency. SPOOCs displayed diverse dynamics in space and frequency and were differentially modulated during stimulus processing. Linking SPOOCs to local spiking, we demonstrate that these events index rapid reconfigurations of neuronal assemblies. With SPOOChunter, we provide an open-source toolbox that enables systematic detection and analysis of transient, spatially organized population dynamics in high-density electrophysiological recordings. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org/content/10.6...

1 month ago 0 0 0 0
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Timing found to be crucial for spinal cord repair in zebrafish The healing of the spinal cord depends on carefully timed interactions between injured nerve cells and their surrounding environment, according to a new study published in Science Advances by research...

The healing of the spinal cord depends on carefully timed interactions between injured nerve cells and their surrounding environment, according to a new study on zebrafish published in Science Advances by KI researchers 🧪 #SpinalCordInjury #neuroscience news.ki.se/timing-found...

1 month ago 9 5 1 0
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Honorary SWEBAGS Webinar 2026 – SWEBAGS Swedish Basal Ganglia Society

Join us for the Honorary SWEBAGS Webinar 2026 on Fri Feb 27, 11:30 AM (Stockholm), with Professors Glenda Halliday and Maria Grazia Spillantini. No registration needed; link shared closer to the date. #BasalGanglia #Neuroscience swebags.ebrains.se/events/honor...

1 month ago 1 1 0 0

Please share: I am recruiting a PhD student to join my lab in Oslo!

For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.

www.jobbnorge.no/en/available...

#NeuroJobs #NeuroSkyence

2 months ago 43 38 1 1
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A prefrontal cortex map based on single-neuron activity - Nature Neuroscience The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function.

A study in Nature Neuroscience maps spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function. #Neuroskyence 🧪

2 months ago 32 4 0 0

inspiring to have witnessed the evolution from idea to publication, congratulations all authors!

3 months ago 6 0 0 0
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New brain maps challenge traditional descriptions of the brain For more than a century, maps of the brain have been based on how brain tissue looks under the microscope. These anatomical maps divide the brain into regions according to structural variations in the...

Activity-based maps of the prefrontal cortex in mice, presented in @natneuro.nature.com today, challenge classical descriptions of the brain. The new maps reveal functional territories that differ from traditional, tissue-based maps. #Neuroscience #Brain 🧪 news.ki.se/new-brain-ma...

3 months ago 14 7 1 0

incredibly sad

3 months ago 1 0 0 0
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Single-cell atlas of striatal cells from early-stage Parkinson's mouse models and Parkinson's patients.

Single-cell atlas of striatal cells from early-stage Parkinson's mouse models and Parkinson's patients.

CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪

🔗 bit.ly/4ju4MmS

3 months ago 7 3 0 0
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✨ Deadline extended! You now have until 22 January 2026 to nominate inspiring Europe-based students or PIs for the ALBA-FKNE Diversity Prize. Honouring work advancing #diversity #equity & #inclusion in #neuroscience. Self-nominations are welcome.

🏆 €2000 + travel to #FENS2026
👉🏾 loom.ly/elEwkCE

3 months ago 0 3 0 3
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Dual cholinergic mechanisms for sculpting striatal dopamine in vivo Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic in...

Excited to share latest study from the lab by an amazing RA, Dylan Flink.

We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle.

www.biorxiv.org/content/10.6...
🧵...

3 months ago 35 12 5 1
Karolinska Institutet - ett medicinskt universitet Karolinska Institutet är ett av Europas största medicinska universitet. I Sverige har KI det största utbudet av medicinska utbildningar och står för den enskilt största andelen av den medicinska akade...

Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS!

www.nature.com/articles/s41...

@ellorens.bsky.social
@ki.se
@natneuro.nature.com

4 months ago 15 4 1 1

very impressive work!

4 months ago 0 0 1 0

thank you Arif!

4 months ago 0 0 0 0
Brain circuit controlling compulsive behavior mapped Researchers at Karolinska Institutet in Sweden have identified a brain circuit that can drive repetitive and compulsive behaviours in mice, even when natural rewards such as food or social contact are...

www.eurekalert.org/news-release...

5 months ago 3 0 1 0
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A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit A brain circuit shapes competition between repetitive and goal-directed behavior.

www.science.org/doi/10.1126/...

5 months ago 2 0 0 0
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🔔 Nominations for the 2026 #ALBA-#FKNE Diversity Prize are now open!

Highlight scientists driving progress in diversity, equity and inclusion in #BrainResearch. 🧠

🗓️ Submit your nominations by 8 January 2026
👉 https://loom.ly/IbLJuVQ

5 months ago 2 2 1 0
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First page of Opinion piece: "Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism"

First page of Opinion piece: "Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism"

The link between the gut #microbiome and autism is not backed by science, researchers say.

Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA

@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social

5 months ago 245 122 5 30

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

5 months ago 17 5 0 0

congratulations 🍾

5 months ago 1 0 0 0
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A new map of the brain to reveal our thinking | Knut and Alice Wallenberg Foundation Research on the structure of the brain has made great strides in recent years. However, Marie Carlén believes a new approach is needed to move forward. She is developing entirely new concepts and meth...

Wallenberg Scholar Marie Carlén is developing entirely new concepts and methods to analyze the brain’s electrical activity in the hope of elevating our understanding of cognition to a new level #research #science #neuroscience #brain @ki.se @carlenlab.bsky.social
kaw.wallenberg.org/en/research/...

5 months ago 5 1 0 0
Members of Team Cragg from Oxford and Karolinska gathered at the Sherrington Library, joined remotely by colleagues from Boston.

Members of Team Cragg from Oxford and Karolinska gathered at the Sherrington Library, joined remotely by colleagues from Boston.

Professor Stephanie Cragg with Oxford and Karolinska colleagues at Christ Church College, celebrating the close of an inspiring first day of the symposium.

Professor Stephanie Cragg with Oxford and Karolinska colleagues at Christ Church College, celebrating the close of an inspiring first day of the symposium.

We were thrilled to (mostly) meet in-person last week for the 3rd Annual Symposium of ASAP Collaboration for Team Cragg!

Thank you all for an inspiring meeting of science, sharing and #collaboration. We have built a great momentum, and we are ready for new discoveries in #Parkinsons research!

5 months ago 8 5 1 0
A LEAP into the future, or off a cliff: Wellcome LEAP's new $50M program A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...

New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic

6 months ago 123 78 12 20
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!

apply.interfolio.com/174756

6 months ago 130 94 2 5
Photo: Cecilia Odlind

Photo: Cecilia Odlind

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

6 months ago 110 33 3 5
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Postdoktor i Diabetes och Parkinsons sjukdom Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för

Postdoc Opportunity at Karolinska Institutet: We're seeking an electrophysiologist to join an exciting collaborative project focusing on diabetes and Parkinson's disease.

Join us!

ki.varbi.com/what:job/job...

6 months ago 4 4 0 1
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Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship) Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet

👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻

Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms.

🚨 Deadline Oct 1st!! 🚨

Please re-post and help us spread the word far and wide! ✈

ki.varbi.com/en/what:job/...

6 months ago 10 9 0 0
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very exciting to share the result of a collaborative effort to map the molecular changes in the mouse and human striatum in Parkinson’s, revealing new biological targets and vulnerability of specific cell types with disease progression

7 months ago 9 3 0 1
My Lab Displayed A Message of Solidarity on Our Windows. Harvard Took It Down. | Opinion | The Harvard Crimson If we continue down this path, we risk not only Harvard’s future as an institution of free inquiry and expression but also its integrity and trustworthiness.

Wrote a eulogy for the yellow letters in my office window. www.thecrimson.com/article/2025...

7 months ago 121 51 4 7