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Posts by Paul Flicek

I've previously put an explicit line in the acknowledgements stating which grant paid the publication fee just like when one grant pays for one person.

1 hour ago 2 0 0 0
We're moving! Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed one hour north on I-95 to set up shop at Johns Hopkins University. This is a very bittersweet move for me, as NHGRI has prov...

Friday was my last day at NHGRI. After 10 wonderful years, my lab is headed to Johns Hopkins University
genomeinformatics.github.io/movingday/

2 days ago 133 19 15 1
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Look at the women at NASA.

They are the ones pushing the boundaries of science, solving problems most people can’t even understand, and carrying this country forward, while our politicians right now posture and stumble through talking points.

And they are doing it all with joy.👇

1 week ago 19509 4166 424 193
GBE Virtual Collection on Conservation Genomics

Photo credit: Chuya Shinzato

GBE Virtual Collection on Conservation Genomics Photo credit: Chuya Shinzato

Genome Biology and Evolution launches a new virtual collection on "Conservation Genomics"

Read our accompanying Highlight: "Genome Science at the Forefront of Biodiversity's Greatest Challenges"
🔗 buff.ly/qBGcsG7

Access the new virtual collection
🔗 buff.ly/VxXZUKv

#genome #evolution #congen

2 weeks ago 18 9 1 0
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In memoriam: Philip Bourne, founding dean of the School of Data Science The leader, who propelled the school from a concept to national recognition, had battled mesothelioma.

Saddened to hear of Phil Bourne's death. I first encountered him as chair of ISMB 2000 in San Diego at my first ever computational biology conference. He always pushed for open science and always tried to make things better. In both he made a positive difference

news.virginia.edu/content/memo...

1 month ago 1 0 0 0
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Crushed to hear of Mark Batzer’s passing. He was the Boyd Professor at Louisiana State University. His influential research revealed how mobile elements shape the genomes of humans & other mammals. Mark’s personality, generosity & positivity were larger than life. He lifted everyone up. HUGE loss 💔

3 months ago 12 6 0 0
chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

Currently dorking out over this graph about child mortality with my brother. Just mind boggling to take in.

4 months ago 2486 968 72 160
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Never a doubt 😁

5 months ago 1 0 0 0

Congratulations Zam! This is fantastic news!

5 months ago 0 0 1 0

My lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social

Please help to spread the word!

Adverts with full details below ⬇️

1 year ago 25 31 2 1

Celebrating all of the amazing women in science I've had as mentors, role models, colleagues and friends 🧬👩‍💻🧪

1 year ago 7 0 0 0
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The Dictator's Handbook - Wikipedia

Not sure if this is exactly what you are looking for, but I found this book to be very enlightening en.m.wikipedia.org/wiki/The_Dic...

1 year ago 1 0 0 0

Congratulations Jill! That is fantastic news

1 year ago 1 0 0 0

A phenomenal effort to bring this together with so many interesting aspects of how genetic background influences cancer development. I'm honoured to have been part of this project!

1 year ago 5 1 1 0
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Genetic background sets the trajectory of cancer evolution Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

🧵[1/12]

1 year ago 83 26 8 5
Associate Professor / Professor of Evolutionary Genomics - Job Opportunities - University of Cambridge Associate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.

Associate Professor / Professor of Evolutionary Genomics
www.jobs.cam.ac.uk/job/49389/

1 year ago 67 76 2 1
Meeting topics and invited list of speakers

Meeting topics and invited list of speakers

Abstract submissions are still open for the CSHL Network Biology meeting in March 11 - 15 2025 (abstract deadline: Jan 10). A large fraction of talks will be selected from the abstracts. On behalf of the organizers, we look forward to welcoming you there.
meetings.cshl.edu/meetings.asp...

1 year ago 16 7 1 0
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Chicken chicken chicken

1 year ago 1 0 0 0

Thanks. I'll check it out

1 year ago 0 0 0 0

Doesn’t seem to be. Many of the JGI authors on this paper have been working on understanding UCEs (with considerable success) at least since the 2007 Ahituv paper that knocked out some UCEs and got viable, apparently normal mice. Knocking out this element results in clear limb abnormalities

1 year ago 1 0 1 0

I’ve just read this pre-print and it’s fantastic. A conserved element with no endogenous enhancer activity is nonetheless necessary and sufficient for extreme long range enhancer action. Recommend to anyone interested in gene regulation

1 year ago 28 4 1 1

This looks like a great meeting! In a great place too

1 year ago 2 0 0 0

The events of this week suggest that the excitement and hype around AI in science won’t be dying down anytime soon

1 year ago 2 0 1 0

8/tl;dr: In most situations, it is to the author's maximal benefit to license their manuscripts thusly:

preprints: any CC license
journal publication: CC BY only

🧪 #AcademicSky

1 year ago 8 4 0 0

Far from the Tree / Andrew Solomon
The Sports Gene / David Epstein
The Vaccine Race / Meredith Wadman

And others listed already

1 year ago 2 0 0 0
The cover of a scientific comic titled "What's Wrong with this DNA?"

The cover of a scientific comic titled "What's Wrong with this DNA?"

The comic is part of the scientific outreach activities from the MRC Toxicology Unit in Cambridge and the home
@s-j-aitken.bsky.social's research group

1 year ago 2 0 0 0
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Pervasive lesion segregation shapes cancer genome evolution - Nature Mutagenic lesions such as those that give rise to cancer frequently segregate—unrepaired—during cell division, resulting in phasing of multiple alleles across generations of daughter cells and co...

The story is based on the discovery of lesion segregation a few years ago (www.nature.com/articles/s41...), in a project that I played a part in, which is a great read too

1 year ago 2 0 2 0
Whats wrong with this DNA? ENG - Google Drive

Celebrate #DNADay by reading the comic (and scientifically accurate 🧪) adventures from Cell Town, home of Pol, Hely, Topy, and the Repair Squad as they set out on another round of cell division! drive.google.com/drive/folder...

1 year ago 6 1 2 0

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

2 years ago 30 11 2 0
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Improving whole genome sequence data analyses Christine Beck and Peter Audano are at the forefront of research involving long-read sequence data. They are particularly interested in structural variants, where segments of the genome are deleted, i...

At the forefront of research involving long-read sequence data, JAX's @christinebeck.bsky.social & Peter Audano discuss how adjustments to the technical and analytical infrastructure are needed. Read more in their recent Genome Research paper 🧪🤝🖥️ 🧬 :
www.jax.org/news-and-ins...

2 years ago 3 2 0 0