Strep GBI 2026 registration is open. Join us for Streptococcus focused research. Keynote from Tom Parks @tom-parks.bsky.social "Streptococcus pyogenes - lessons from the host"

📌 Durham, March 30-31
🌐 strepgbi.wixsite.com/strep-gbi.

Registration/abstracts
👉 pay.durham.ac.uk/event-durham.

Immunity to S pyogenes and Common Respiratory Viruses at Age 0 to 4 Years This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...

Finally, we urgently need to invest in development of #StrepA vaccines to prevent these life-threatening infections as well as other #StrepA diseases like #RHD.

tiny.cc/63vt001

We think this might provide a biological basis for the 2022 to 2023 upsurge in severe #StrepA infections in young children.

More importantly, it underscores the vulnerability of young children to dangerous #StrepA infections.

Key messages:

Children aged 3-4 were ~1 year behind in #StrepA immunity after the pandemic

This is the age group that experienced the greatest increase in life-threatening Strep A in 2022-23.

We saw substantial changes in detection of common pathogens like #StrepA during the pandemic as previously reported.

We measured #StrepA antibodies in samples from children recruited to the PERFORM and DIAMONDS studies before and after the pandemic.

We focused on the group who were as representative as possible of children in the wider population excluding those with definite bacterial and viral infections.

I’m hugely grateful to the many people who contributed, especially the @horizoneu.bsky.social funded DIAMONDS and PERFORM studies

Key additional funding from @wellcometrust.bsky.social
@ukri.org

Important support from @imperialinfect.bsky.social and @imperialbrc.bsky.social and many others.

Immunity to S pyogenes and Common Respiratory Viruses at Age 0 to 4 Years This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...

Why did severe #StrepA infections in children increase after the pandemic?

Our new @jamanetworkopen paper suggests COVID restrictions delayed immunity development in young children.

tiny.cc/63vt001

Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0-4 Years after COVID-19 restrictions: A Cross-Sectional Study Importance The upsurge in invasive disease caused by Streptococcus pyogenes among children reported in several European countries during 2022-2023 has not been fully explained. Objective To test the ...

Why did invasive #strepA infections increase in young children after the pandemic?

In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:

www.medrxiv.org/cgi/content/...

Is there still rheumatic fever in the UK? bit.ly/3Py0X1P Join our @rcpch.bsky.social webinar next Friday to hear the answer as well as get a refresher on the clinical features and how we make or refute the diagnosis. #strepA #GAS #RHD #IDSky #PaedsSky #PaedsIDSky

UK adult & paediatric Infectious Diseases clinicians. Would your site be interested in participating in an adaptive platform trial on invasive Group A Strep? We are developing our application currently - so if interested do get in touch with me.

#IDSky

Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨

We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.

Lead author @gushamilton.bsky.social

#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
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